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Found 467 clinical trials
Featured trial
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative

diabetes. One disorder, psoriasis, is an inflammation that mostly affects the skin but can affect the entire body. Another disorder, atherosclerosis, is a process in which cholesterol is gradually deposited

cholesterol measurement
diabetes
heart disease
atherosclerosis
  • 123 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Inflammatory Characterization of Known or Possible Cardiovascular Diseases

Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pain). Inflammation affects the entire body. Researchers will study this relationship …

diabetes
heart disease
fats
  • 167 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Crest-2: CAROTID REVASCULARIZATION AND MEDICAL MANAGEMENT FOR ASYMPTOMATIC CAROTID STENOSIS TRIAL (CREST-2) PROTOCOL

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will …

  • 0 views
  • 08 Jan, 2022
  • 1 location
Featured trial
Are you 65 or over with high cholesterol?

Are you 65 or over with high cholesterol?

  • 198 views
  • 08 Nov, 2020
  • 1 location
Effects of Statin for Elderly Patients With Atherosclerotic Cardiovascular Disease

High-dose statins can reduce mortality and cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD). Therefore, US and European recommendations recommend

cardiovascular disease
LDL Cholesterol
ezetimibe
hmg-coa reductase inhibitors
rosuvastatin
  • 0 views
  • 12 Dec, 2021
  • 2 locations
A Multicenter, Cross-sectional Study to Characterize the Distribution of Lipoprotein(a) Levels Among Patients With Documented History of Atherosclerotic Cardiovascular Disease

The purpose of this study is to characterize the distribution of lipoprotein(a) (Lp(a)) levels among participants with a history of ASCVD as defined by their medical history and is 2-fold:

  • 0 views
  • 17 Sep, 2022
  • 338 locations
Effects of Ezetimibe Combination Therapy for Patients With Atherosclerotic Cardiovascular Disease; Randomized Comparison of LDL-cholesterol Targeting <70 Versus <55mg/dL; Ez-PAVE Trial

therapy will have more prominent beneficial effect compared to conventional-targeting in patients with documented ASCVD with either an ezetimibe/statin combination therapy or a statin monotherapy.

  • 0 views
  • 21 Jun, 2021
  • 1 location
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease (ORION-4)

ORION-4 is a research study coordinated by the University of Oxford and co-sponsored by The University of Oxford and Novartis (Protocol: CTSU_MDCO-PCS-17-01 (CKJX839B12301)). The study aims to find out if a new cholesterol-lowering injection (inclisiran) safely lowers the risk of heart attacks and strokes in people who have already had …

cardiovascular disease
stroke
myocardial infarction
inclisiran
arterial disease
  • 4 views
  • 17 Mar, 2022
  • 1 location
A Randomized, Double-blind, Placebo-controlled, Multicenter Trial, Assessing the Impact of Inclisiran on Major Adverse Cardiovascular Events in Participants With Established Cardiovascular Disease (VICTORION-2 PREVENT) (VICTORION-2P)

Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants with established cardiovascular disease (CVD).

  • 1 views
  • 14 Sep, 2022
  • 583 locations
Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

This is a single arm, open label, multi centre phase III study to evaluate the efficacy and long term safety of lomitapide in paediatric patients with HoFH receiving stable LLT (including LA, when applicable) comprising of the following phases: Screening Period (starting at Week 12, i.e. ≤12 weeks prior to …

  • 0 views
  • 26 Apr, 2022
  • 11 locations