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Found 500 clinical trials
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Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative

diabetes. One disorder, psoriasis, is an inflammation that mostly affects the skin but can affect the entire body. Another disorder, atherosclerosis, is a process in which cholesterol is gradually deposited

diabetes
atherosclerosis
heart disease
cholesterol measurement
  • 47 views
  • 23 Nov, 2020
  • 1 location
featured
HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease

The ORION-4 clinical trial aims to test a new, twice annual cholesterol injectable medication called inclisiran which has no known side effects. Inclisiran is a PCSK9 gene inhibitor that prevents the PCSK9 from circulating and destroying the body's LDL ("bad" cholesterol) receptors which digest LDL. Inclisiran enhances the effects of …

  • 97 views
  • 11 Jun, 2020
  • 1 location
featured
Inflammatory Characterization of Known or Possible Cardiovascular Diseases

Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pain). Inflammation affects the entire body. Researchers will study this relationship …

fats
diabetes
heart disease
  • 46 views
  • 23 Nov, 2020
  • 1 location
featured
Are you 65 or over with high cholesterol?

Are you 65 or over with high cholesterol?

  • 104 views
  • 08 Nov, 2020
  • 1 location
Effect of Atorvastatin and Lifestyle Intervention on Progression of Pre-Clinical Atherosclerosis

atherosclerosis.

diabetes
atorvastatin
atherosclerosis
  • 4 views
  • 07 Nov, 2020
  • 1 location
Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease

with elevated risk for atherosclerotic cardiovascular disease (ASCVD). ASCVD is the leading cause of morbidity and mortality in the United States. Regular physical activity has been shown to reduce the

cardiovascular disease
  • 2 views
  • 25 Jan, 2021
  • 1 location
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease

ORION-4 is a research study coordinated by the University of Oxford and co-sponsored by The University of Oxford and The Medicines Company. The study aims to find out if a new cholesterol-lowering injection (inclisiran) safely lowers the risk of heart attacks and strokes in people who have already had one …

stroke
inclisiran
cardiovascular disease
myocardial infarction
arterial disease
  • 0 views
  • 23 Jan, 2021
  • 1 location
The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes

The endothelial dysfunction is the early event in atherosclerosis. The investigator previous study showed that impaired endothelial function exist in newly diagnosed type 2 diabetes. The

hypertension
diabetes
atherosclerosis
blood lipids
type 2 diabetes mellitus
  • 0 views
  • 08 Nov, 2020
  • 1 location
China Intensive Lipid Lowering With Statins in Acute Coronary Syndrome

effects of statin therapy on regression of coronary atherosclerosis using IVUS.

hmg-coa reductase inhibitor
LDL Cholesterol
atorvastatin
cardiac event
intravascular ultrasound
  • 0 views
  • 07 Nov, 2020
  • 1 location
Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Individuals receiving dialysis are at risk of heart failure and heart related death. There is an urgent need for treatments that reduce the risk of these problems in patients that require dialysis. Spironolactone is a pill used to prevent heart failure and related deaths in patients that do not require …

  • 41 views
  • 25 Jan, 2021
  • 98 locations