Found 548 clinical trials
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative
diabetes. One disorder, psoriasis, is an inflammation that mostly affects the skin but can affect the entire body. Another disorder, atherosclerosis, is a process in which cholesterol is gradually deposited
- 47 views
- 23 Nov, 2020
- 1 location
HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease
The ORION-4 clinical trial aims to test a new, twice annual cholesterol injectable medication called inclisiran which has no known side effects. Inclisiran is a PCSK9 gene inhibitor that prevents the PCSK9 from circulating and destroying the body's LDL ("bad" cholesterol) receptors which digest LDL. Inclisiran enhances the effects of …
- 97 views
- 11 Jun, 2020
- 1 location
Inflammatory Characterization of Known or Possible Cardiovascular Diseases
Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pain). Inflammation affects the entire body. Researchers will study this relationship …
- 46 views
- 23 Nov, 2020
- 1 location
Are you 65 or over with high cholesterol?
Are you 65 or over with high cholesterol?
- 104 views
- 08 Nov, 2020
- 1 location
Effect of Atorvastatin and Lifestyle Intervention on Progression of Pre-Clinical Atherosclerosis
atherosclerosis.
- 4 views
- 07 Nov, 2020
- 1 location
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease
ORION-4 is a research study coordinated by the University of Oxford and co-sponsored by The University of Oxford and Novartis (Protocol: CTSU_MDCO-PCS-17-01 (CKJX839B12301)). The study aims to find out if a new cholesterol-lowering injection (inclisiran) safely lowers the risk of heart attacks and strokes in people who have already had …
- 0 views
- 15 May, 2021
- 1 location
Behavioral Economic Approaches to Increase Physical Activity Among Patients With Elevated Risk for Cardiovascular Disease
with elevated risk for atherosclerotic cardiovascular disease (ASCVD). ASCVD is the leading cause of morbidity and mortality in the United States. Regular physical activity has been shown to reduce the
- 2 views
- 13 May, 2021
- 1 location
Effects of Ezetimibe Combination Therapy for Patients With Atherosclerotic Cardiovascular Disease; Randomized Comparison of LDL-cholesterol Targeting <70 Versus <55mg/dL; Ez-PAVE Trial
therapy will have more prominent beneficial effect compared to conventional-targeting in patients with documented ASCVD with either an ezetimibe/statin combination therapy or a statin monotherapy.
- 0 views
- 21 Jun, 2021
- 1 location
The Effect of Intensive Multifactorial Therapy on Endothelial Function in Newly Diagnosed Type 2 Diabetes
The endothelial dysfunction is the early event in atherosclerosis. The investigator previous study showed that impaired endothelial function exist in newly diagnosed type 2 diabetes. The
- 0 views
- 08 Nov, 2020
- 1 location
China Intensive Lipid Lowering With Statins in Acute Coronary Syndrome
effects of statin therapy on regression of coronary atherosclerosis using IVUS.
- 0 views
- 07 Nov, 2020
- 1 location