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Found 493 clinical trials
Featured trial
Human Translational Studies of Inflammation and Cardiometabolic Diseases: The Psoriasis, Atherosclerosis and Cardiometabolic Disease (PACI) Initiative

diabetes. One disorder, psoriasis, is an inflammation that mostly affects the skin but can affect the entire body. Another disorder, atherosclerosis, is a process in which cholesterol is gradually deposited

diabetes
heart disease
cholesterol measurement
atherosclerosis
  • 95 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Inflammatory Characterization of Known or Possible Cardiovascular Diseases

Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes. Researchers want to learn if there is a relationship between these diseases and inflammation (redness, swelling, and pain). Inflammation affects the entire body. Researchers will study this relationship …

diabetes
fats
heart disease
  • 163 views
  • 23 Nov, 2020
  • 1 location
Featured trial
Crest-2: CAROTID REVASCULARIZATION AND MEDICAL MANAGEMENT FOR ASYMPTOMATIC CAROTID STENOSIS TRIAL (CREST-2) PROTOCOL

Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. One trial will randomize patients in a 1:1 ratio to endarterectomy versus no endarterectomy and another will …

  • 0 views
  • 08 Jan, 2022
  • 1 location
Featured trial
A randomized, double-blind, placebo-controlled multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease

We are seeking participants for a clinical research study who have Atherosclerotic Cardiovascular Disease (thickening/hardening of the arteries which is caused by a buildup of plaque in the

hmg-coa reductase inhibitor
atherosclerotic cardiovascular disease
stroke
  • 0 views
  • 31 May, 2022
  • 1 location
Featured trial
Are you 65 or over with high cholesterol?

Are you 65 or over with high cholesterol?

  • 198 views
  • 08 Nov, 2020
  • 1 location
A Cross-sectional Study of Lipoprotein(a) Levels in Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)

The purpose of this study is to characterize the distribution of lipoprotein(a) (Lp(a)) levels among participants with a history of ASCVD as defined by their medical history and is 2-fold:

  • 0 views
  • 15 Jun, 2022
  • 51 locations
Effects of Statin for Elderly Patients With Atherosclerotic Cardiovascular Disease

High-dose statins can reduce mortality and cardiovascular events in patients with established atherosclerotic cardiovascular disease (ASCVD). Therefore, US and European recommendations recommend

hmg-coa reductase inhibitors
cardiovascular disease
LDL Cholesterol
ezetimibe
rosuvastatin
  • 0 views
  • 12 Dec, 2021
  • 2 locations
A Randomized Trial Assessing the Effects of Inclisiran on Clinical Outcomes Among People With Cardiovascular Disease (ORION-4)

ORION-4 is a research study coordinated by the University of Oxford and co-sponsored by The University of Oxford and Novartis (Protocol: CTSU_MDCO-PCS-17-01 (CKJX839B12301)). The study aims to find out if a new cholesterol-lowering injection (inclisiran) safely lowers the risk of heart attacks and strokes in people who have already had …

arterial disease
myocardial infarction
stroke
cardiovascular disease
inclisiran
  • 4 views
  • 17 Mar, 2022
  • 1 location
Effects of Ezetimibe Combination Therapy for Patients With Atherosclerotic Cardiovascular Disease; Randomized Comparison of LDL-cholesterol Targeting <70 Versus <55mg/dL; Ez-PAVE Trial

therapy will have more prominent beneficial effect compared to conventional-targeting in patients with documented ASCVD with either an ezetimibe/statin combination therapy or a statin monotherapy.

  • 0 views
  • 21 Jun, 2021
  • 1 location
Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease (VICTORION-2P)

Study CKJX839B12302 is a pivotal Phase III trial to evaluate the benefits of inclisiran on major adverse cardiovascular (MACE) events in participants with established cardiovascular disease (CVD).

  • 0 views
  • 23 May, 2022
  • 375 locations