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Found 253 clinical trials
Mycophenolate Mofetil Combined With Radiation Therapy in Glioblastoma

This is a phase 0/1 dose-escalation trial to determine the maximum tolerated dose of Mycophenolate Mofetil (MMF) when administered with radiation, in patients with glioblastoma or gliosarcoma.

karnofsky performance status
glioblastoma multiforme
temozolomide
mycophenolate mofetil
gliosarcoma
  • 0 views
  • 23 Jul, 2022
  • 1 location
PARP Inhibition for Gliomas (PI-4G or π4g)

The purpose of this study is to determine what effects (good and bad) niraparib has on patients with recurrent brain cancer.

  • 0 views
  • 12 Aug, 2022
  • 1 location
A Phase 1/1b Adaptive Dose Escalation Study of Mycophenolate Mofetil (MMF) in Combination With Standard of Care for Patients With Glioblastoma

This phase I/Ib trial tests the safety, side effects, and best dose of mycophenolate mofetil in combination with temozolomide and/or radiation therapy (standard of care) in treating patients with glioblastoma. Mycophenolate mofetil is an immunosuppressant drug that is typically used to prevent organ rejection in transplant recipients. However, mycophenolate mofetil …

  • 0 views
  • 20 Sep, 2022
  • 1 location
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S

with advanced or metastatic cancers with high LAT1 expression. The MTD of QBS10072S will be confirmed in patients with relapsed or refractory grade 4 astrocytoma.

measurable disease
kidney function test
thymic carcinoma
cancer
cancer, thymic
  • 207 views
  • 01 May, 2022
  • 2 locations
Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

the treatment of newly diagnosed glioblastoma multiforme (GBM) and refractory anaplastic astrocytoma cancers. Temozolomide is considered experimental because it is not approved by the FDA for

imatinib
cancer
renal function
glioblastoma multiforme
renal function test
  • 11 views
  • 12 Feb, 2022
  • 4 locations
A Phase I/IIa Study of Cerebraca Wafer Plus Adjuvant Temozolomide (TMZ) in Patients With Recurrent High Grade Glioma

High Grade Glioma. High grade gliomas, glioblastoma multiforme (grade IV) and anaplastic anaplastic astrocytoma (Grade III), are the most comment malignant brain tumor. The cause of gliomas

  • 0 views
  • 06 Apr, 2021
  • 3 locations
Clinical Study of Apatinib Combined With Temozolomide in the Treatment of Uncontrolled or Repeated High-grade Gliomas

. Interstitial astrocytomas and glioblastomas are also called high-grade gliomas, accounting for 77.5% of all gliomas.

  • 0 views
  • 25 Feb, 2022
  • 1 location
Phase I Study of Oral ONC206 in Recurrent and Rare Primary Central Nervous System Neoplasms

The primary objective of this phase 1 trial is to determine the maximum tolerated dose (MTD), food effect, safety and tolerability of oral ONC206 in patients with recurrent, primary CNS neoplasms.

astrocytoma, anaplastic
measurable disease
ependymoma
medulloblastoma
oligodendroglioma, anaplastic
  • 10 views
  • 12 Mar, 2022
  • 1 location
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) (HIT-HGG-2013)

> gliomas glioblastoma WHO grade IV (GBM) diffuse midlineglioma histone 3 K27M mutated WHO grade IV (DMG) anaplastic astrocytoma WHO grade III (AA

temozolomide
glioblastoma multiforme
epilepsy
malignant glioma
astrocytoma
  • 44 views
  • 16 Jun, 2022
  • 50 locations
Phase II Trial of LB100, a Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma

Background The brain is separated from the rest of the blood stream by the blood-brain barrier. This is like a filter that protects the brain. But is also a challenge when medicines need to get into the brain. Researchers want to give the new drug LB100 to people before brain …

recurrent glioblastoma
brain tumor
recurrent disease
oligodendroglioma
renal function
  • 22 views
  • 19 Sep, 2022
  • 1 location