Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 253 clinical trials
PRO-GLIO: PROton Versus Photon Therapy in IDH-mutated Diffuse Grade II and III GLIOmas

Proton therapy is a powerful tool enabling oncologists to spare normal tissue around the target for irradiation much better than what can be achieved with photon irradiation. The infiltrative nature of IDH-mutated grade II and III diffuse glioma, however, renders proton therapy a potential problem. A randomized controlled trial (RCT) …

oligodendroglioma
flair
MRI
astrocytoma
  • 0 views
  • 21 Mar, 2022
  • 1 location
Temporally-modulated Pulsed Radiation Therapy (TMPRT) After Prior EBRT for Recurrent IDH-mutant Gliomas

This clinical trial studies the side effects of temporally-modulated pulsed radiation therapy (TMPRT) in patients with IDH-mutant gliomas who have previously received radiation therapy to the brain. TMPRT is a radiation technique in which radiation is delivered in multiple small doses on a specific timed interval, instead of delivering one …

oligodendroglioma
recurrent tumor
karnofsky performance status
astrocytoma
  • 0 views
  • 24 Jul, 2022
  • 1 location
A Phase II Study of Hippocampal-Avoidance Using Proton Therapy in Low-Grade Glioma

manner. To investigate whether the methylation profiles of LGGs differ by tumor location (thalamic/midbrain vs. hypothalamic/optic pathway vs. others) and histologies (pilocytic astrocytoma vs

low grade glioma
recurrent tumor
pleomorphic xanthoastrocytoma
astrocytoma
pilocytic astrocytoma
  • 3 views
  • 23 Sep, 2022
  • 2 locations
Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma

Low-grade glioma (LGG) is a common primary brain tumor in young adults. The infiltrative nature and frequent growth in eloquent area in brain often makes total resection impossible. Until now, no agreement has been achieved on the treatment of LGG without total resection. Post-radiation adjuvant temozolomide (TMZ) is currently the …

complete resection
low grade glioma
astrocytoma
brain tumor
oligodendroglioma
  • 37 views
  • 24 Jan, 2021
  • 1 location
Trial of C134 in Patients With Recurrent GBM (C134-HSV-1)

The purpose of this project is to obtain safety information in small groups of individuals, scheduled to receive escalating doses of C134, a cancer killing virus (HSV-1) that has been genetically engineered to safely replicate and kill glioma tumor cells. Safety will be assessed at each dose level before proceeding …

  • 14 views
  • 24 Mar, 2022
  • 1 location
Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma

This phase I trial studies best dose and side effects of oncolytic adenovirus DNX-2401 in treating patients with high-grade glioma that has come back (recurrent). Oncolytic adenovirus DNX-2401 is made from the common cold virus that has been changed in the laboratory to make it less likely to cause an …

astrocytoma
nitrosoureas
lomustine
gliosarcoma
procarbazine
  • 10 views
  • 30 Apr, 2022
  • 1 location
Maximum Tolerated Dose, Safety, and Efficacy of Rhenium Nanoliposomes in Recurrent Glioma (ReSPECT)

This is a multi-center, sequential cohort, open-label, volume and dose escalation study of the safety, tolerability, and distribution of 186RNL given by convection enhanced delivery to patients with recurrent or progressive malignant glioma after standard surgical, radiation, and/or chemotherapy treatment. The study uses a modified Fibonacci dose escalation, followed by …

glioblastoma multiforme
corticosteroids
bevacizumab
temozolomide
recurrent glioma
  • 173 views
  • 25 Jul, 2022
  • 3 locations
Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016)

This trial studies how well fimepinostat works in treating patients with newly diagnosed diffuse intrinsic pontine glioma, or medulloblastoma, or high-grade glioma that have come back. Fimepinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

fimepinostat
corticosteroids
astrocytoma
nitrosoureas
growth factor
  • 3 views
  • 23 Jul, 2022
  • 21 locations
Phase I Study to Evaluate the Safety and Tolerability of the CD40 Agonistic Monoclonal Antibody APX005M in Pediatric Subjects With Recurrent/Refractory Brain Tumors and Newly Diagnosed Brain Stem Glioma

This phase I trial studies the side effects and best dose of APX005M in treating younger patients with primary malignant central nervous system tumor that is growing, spreading, or getting worse (progressive), or newly diagnosed diffuse intrinsic pontine glioma. APX005M can trigger activation of B cells, monocytes, and dendritic cells …

nitrosourea
astrocytoma
nitrosoureas
growth factor
gliosarcoma
  • 167 views
  • 19 Aug, 2022
  • 11 locations
Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

This is a 2-part multicenter Phase 1b study designed to test icapamespib in patients with recurrent brain lesions. Part 1 of the trial will be a standard 3 by 3 dose escalation design where different doses are examined. Part 2 will be a dose expansion cohort to further evaluate the …

  • 0 views
  • 30 May, 2022
  • 5 locations