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Found 253 clinical trials
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

The investigational drug to be studied in this protocol, BCA101, is a first-in-class compound that targets both EGFR with TGFβ. Based on preclinical data, this bifunctional antibody may exert synergistic activity in patients with EGFR-driven tumors.

monoclonal antibodies
lung cancer
squamous cell carcinoma of head and neck
  • 25 Jul, 2022
  • 8 locations
NKG2D-based CAR T-cells Immunotherapy for Patient With r/r NKG2DL+ Solid Tumors

The primary objective of this study is to evaluate the safety and clinical activity of NKG2D-based CAR-T cells infusion in the treatment of relapsed/refractory NKG2DL+ solid tumors.

blood transfusion
liver metastasis
  • 30 Nov, 2021
  • 1 location
Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors

Prospective, open-label, dose-ranging, uncontrolled phase I/II study of Lurbinectedin in combination with irinotecan. The study will be divided into two stages: a Phase I dose escalation stage and a Phase II expansion stage.

cancer of the ovary
lung cancer
international normalized ratio
  • 26 Jan, 2022
  • 4 locations
Study of NGM707 as Monotherapy and in Combination With Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

Study of NGM707 as Monotherapy and in Combination with Pembrolizumab in Advanced or Metastatic Solid Tumor Malignancies

  • 15 May, 2022
  • 7 locations
9-ING-41 in Patients With Advanced Cancers

GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic agents, in patients with refractory cancers.

serum amylase
glioblastoma multiforme
kidney function tests
cytotoxic agents
  • 29 May, 2022
  • 10 locations
Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and Haematological Malignancies

This is a phase I/II, non randomized, open-label, dose escalation study to investigate the safety, tolerability and preliminary efficacy of CB-103.

anaplastic large cell lymphoma
small molecule
mantle cell lymphoma
growth factor
  • 25 Mar, 2022
  • 14 locations
The BurnAlong Pilot Study for Adolescent and Young Adult Cancer Survivors

The purpose of this prospective, interventional, single-arm pilot study is to evaluate whether virtually delivered group-based physical activity is feasible for adolescent and young adult (AYA) cancer survivors. AYAs who were diagnosed with cancer and have completed cancer treatment will be recruited for this study. This study will enroll 20 …

Accepts healthy volunteers
primary cancer
cancer treatment
  • 12 Mar, 2022
  • 1 location
Research of Biomarkers of Response to Proton Beam Therapy in Pediatric and Adult Patients. (PROTONBIOMARKS)

This trial is a paucicentric, clinico-biological cohort study with retrospective and prospective enrollment, aiming to identify biomarkers predictive of response to Proton Beam Therapy (PBT) in cancer patients (high grade sarcoma, brain tumors and meningioma). This study include collection of clinical data, of tumor samples (collected during standard of care) …

tumor cells
karnofsky performance status
measurable disease
brain tumor
  • 11 Aug, 2022
  • 2 locations
The circTeloDIAG: Liquid Biopsy for Glioma Tumor

Gliomas represent the most frequent primary brain tumor, with 2,500 to 3,000 new cases per year in France. Their diagnosis, although highly complex, is essential for determining patient management. While grade I gliomas (infrequent) are curable by surgery or present a slow progression, grades II to IV require heavy treatment …

recurrent glioma
primary brain tumors
brain tumor
  • 17 Aug, 2021
  • 1 location
Collecting and Storing Tissue From Young Patients With Cancer

This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and …

acute lymphoblastic leukemia (all)
germ cell tumors
ewing sarcoma/peripheral primitive neuroectodermal tumor
ewing sarcoma family of tumors
  • 14 Mar, 2022
  • 24 locations