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Found 254 clinical trials
PEskE: A Phase 0/Surgical Window-of-opportunity Study to Evaluate the Pharmacokinetics and Pharmacodynamics of Evolocumab in Patients With Recurrent High-grade Glioma or Glioblastoma

This Phase 0 surgical window of opportunity trial seeks to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) properties of an FDA-approved proprotein convertase/ kexin type 9 serine protease inhibitor (PCSK9i) in patients with primary and recurrent World Health Organization (WHO) grade IV malignant glioma. The investigators intend to evaluate whether …

renal function
neutrophil count
malignant glioma
  • 0 views
  • 29 Oct, 2022
  • 1 location
Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

This study is to determine if an oral drug called Ramipril can lower the chance of memory loss in patients with glioblastoma getting chemoradiation. Patients will take Ramipril during chemoradiation and continue until 4 months post-treatment. Memory loss will be assessed using several neurocognitive tests throughout the duration of the …

complete resection
absolute neutrophil count
neutrophil count
memory loss
temozolomide
  • 120 views
  • 07 Oct, 2022
  • 392 locations
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers

This phase I trial studies how well [18F]DASA-23 and positron emission tomography (PET) scan work in evaluating pyruvate kinase M2 (PKM2) expression in patients with intracranial tumors or recurrent glioblastoma and healthy volunteers. PKM2 regulates brain tumor metabolism, a key factor in glioblastoma growth. [18F]DASA-23 is a radioactive substance with …

cancer
glioblastoma multiforme
positron emission tomography
serum pregnancy test
recurrent glioblastoma
  • 111 views
  • 04 Mar, 2022
  • 1 location
A Study of TAS2940 in Participants With Locally Advanced or Metastatic Solid Tumor Cancer

This is a first-in-human, open label, multicenter study to assess the safety, tolerability, pharmacokinetics, pharmacodynamics, and the preliminary antitumor activity of TAS2940 in patients with advanced or metastatic solid tumors who are not candidates for approved or available therapies.

HER2
EGFR
cancer
her2/neu-positive breast cancer
measurable disease
  • 0 views
  • 11 Mar, 2022
  • 3 locations
Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel for Recurrent Glioblastoma (SC9/ABX)

Paclitaxel is among the most active agents against glioblastoma in preclinical models. However, its clinical use has been hampered by the blood-brain barrier (BBB). In this trial we will implant a novel device with 9 ultrasound emitters allowing to temporarily and reversibly open the BBB immediately prior to chemotherapy infusion …

recurrent tumor
corticosteroids
contrast-enhanced magnetic resonance imaging
glioblastoma multiforme
dexamethasone
  • 25 views
  • 14 Jun, 2022
  • 1 location
Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)

This single center, single arm, open-label, phase I study will assess the safety of a laparoscopically harvested omental free flap into the resection cavity of recurrent glioblastoma multiforme (GBM) patients. All participants included in the study will undergo standard surgical resection for diagnosed recurrent GBM. Following the resection, the surgical …

tumor progression
frozen section
glioblastoma multiforme
blood urea nitrogen
recurrent glioblastoma
  • 20 views
  • 14 Jul, 2022
  • 1 location
LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

MRI
karnofsky performance status
  • 0 views
  • 15 May, 2022
  • 3 locations
SonoClear Acoustic Coupling Fluid (ACF) Mimicking Brain Tissue

The objective of this clinical investigation is to assess the safety and performance of the SonoClear Acoustic Coupling Fluid (ACF). The performance will be assessed by analysis of the contrast-to-noise ratio (CNR) and assessment of image quality by using the Surgeon Image Rating (SIR) Scale. This is a prospective, multi-centre …

MRI
karnofsky performance status
  • 0 views
  • 06 Apr, 2022
  • 2 locations
Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Primary brain cancer kills up to 10,000 Americans a year. These brain tumors are typically treated by surgery, radiation therapy and chemotherapy, either individually or in combination. Present therapies are inadequate, as evidenced by the low 5-year survival rate for brain cancer patients, with median survival at approximately 12 months. …

intraarterial cerebral infusion
TERT
malignant brain tumor
MRI
EGFR
  • 0 views
  • 24 May, 2022
  • 1 location
Brain Tumor Intraoperative Ultrasound Database (BraTioUS-DB)

Predicting the survival of patients diagnosed with glioblastoma (GBM) is essential to guide surgical strategy and subsequent adjuvant therapies. Intraoperative ultrasound (ioUS) is a low-cost, versatile technique available in most neurosurgical departments. The images from ioUS contain biological information possibly correlated to the tumor's behavior, aggressiveness, and oncological outcomes. Today's …

astrocytoma
brain tumor
  • 0 views
  • 05 Jun, 2022
  • 2 locations