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Found 254 clinical trials
Phase II Trial Evaluating Nivolumab In Patients With IDH-Mutant Gliomas With And Without Hypermutator Phenotype

Background Gliomas are the most common malignant brain tumors. Some have certain changes (mutations) in the genes IDH1 or IDH2. If there are a high number of mutations in a tumor, it is called hypermutator phenotype (HMP). The drug nivolumab helps the immune system fight cancer. Researchers think it can …

brain mri
neutrophil count
platelet count
IDH2
dna sequencing
  • 38 views
  • 24 Oct, 2022
  • 1 location
Communication Training for Caregivers to Promote Advanced Care Planning

The purpose of this research study is to develop and test a new communication training to help caregivers communicate more effectively with their loved ones and healthcare professionals about advanced care planning.

brain tumor
malignant brain tumor
cancer
  • 1 views
  • 15 Oct, 2022
  • 1 location
Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Glioblastoma Multiforme (GBM)

This study assesses the safety of using tissue autograft of a pedicled temporoparietal fascial (TPF) or pericranial flap into the resection cavity of newly diagnosed glioblastoma multiforme (GBM) patients. The objective of the study is to demonstrate that this surgical technique is safe in a small human cohort of patients …

frozen section
neutrophil count
karnofsky performance status
MRI
blood urea nitrogen
  • 42 views
  • 21 Oct, 2022
  • 1 location
Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

This phase I trial studies the side effects and best dose of memory-enriched T cells in treating patients with grade II-IV glioma that has come back (recurrent) or does not respond to treatment (refractory). Memory enriched T cells such as HER2(EQ)BB/CD19t+ T cells may enter and express its genes in …

dexamethasone
platelet count
immunohistochemistry
measurable disease
cytotoxic chemotherapy
  • 100 views
  • 04 Oct, 2022
  • 2 locations
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas (PNOC017)

This phase I trial studies the side effects and best dose of BGB-290 and temozolomide in treating adolescents and young adults with IDH1/2-mutant grade I-IV glioma that is newly diagnosed or has come back. BGB-290 may stop the growth of tumor cells by blocking some of the enzymes needed for …

dexamethasone
anticonvulsants
platelet count
IDH2
MRI Scan
  • 38 views
  • 04 Oct, 2022
  • 8 locations
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.

The trial is designed as a multicenter randomized controlled study. 246 patients with presumed Glioblastoma Multiforme in eloquent areas on diagnostic MRI will be selected by the neurosurgeons according the eligibility criteria (see under). After written informed consent is obtained, the patient will be randomized for an awake craniotomy (AC) …

temozolomide
MRI
glioblastoma multiforme
general anesthesia
craniotomy
  • 0 views
  • 04 Oct, 2022
  • 6 locations
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

The purpose of this study is to test how well the drug works, safety and tolerability of an investigational drug called Ruxolitinib in gliomas and glioblastomas, when combined with standard treatment for brain cancer, temozolomide and radiation. Ruxolitinib is an experimental drug that works by targeting proteins in cells and …

malignant glioma
karnofsky performance status
MRI
tumor cells
glioblastoma multiforme
  • 41 views
  • 04 Oct, 2022
  • 2 locations
Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

This is a study of DSP-0390 in patients with recurrent high grade glioma.

dexamethasone
sargramostim
aptt
corticosteroids
  • 5 views
  • 07 Oct, 2022
  • 4 locations
Phase I, Open-label, Multicenter Study to Evaluate the Imaging Performance, Safety, Biodistribution and Dosimetry of [68Ga]-FF58 in Adult Patients With Selected Solid Tumors Expected to Overexpress αvβ3 and αvβ5 Integrins.

This is a First-In-Human (FIH) study of [68Ga]-FF58 to characterize the imaging properties, safety, biodistribution and dosimetry properties of [68Ga]-FF58 in adults with relapsed or refractory (r/r) glioblastoma multiforme (GBM), breast cancer (BC) that has metastasized to the brain, gastroesophageal adenocarcinoma (GEA) or pancreatic ductal adenocarcinoma (PDAC) expected to overexpress …

EGFR
HER2
cancer
bevacizumab
  • 0 views
  • 13 Oct, 2022
  • 1 location
Safety and Efficacy Study of Retifanlimab and Epacadostat in Combination With Radiation and Bevacizumab in Patients With Recurrent Gliomas

In this study, the investigators propose to combine retifanlimab with radiation therapy (RT) and bevacizumab with or without epacadostat in the treatment of recurrent glioblastoma (GBM). The investigators hypothesize that this combination provides a powerful synergy between RT and immune modulators to produce more robust anti-tumor immune response, induce tumor …

neutrophil count
gliosarcoma
measurable disease
astrocytoma
aptt
  • 0 views
  • 28 Oct, 2022
  • 4 locations