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Found 254 clinical trials
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ACNS1022: A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas

ACNS1022: A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients With Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway

  • 52 views
  • 08 Nov, 2020
  • 1 location
An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib)

A roll-over study to assess long-term effect in pediatric patients treated with dabrafenib and/or trametinib.

trametinib
dabrafenib
  • 492 views
  • 29 Oct, 2022
  • 15 locations
Supramarginal Resection in Patients With Glioblastoma: A Randomised Controlled Trial

Gliomas are the most common malignant brain tumor. Glioblastoma, WHO grade IV astrocytoma, is the most common subtype and unfortunately also the most aggressive subtype with median survival in

temozolomide
malignant glioma
complete resection
malignant brain tumor
supratentorial glioblastoma multiforme
  • 0 views
  • 22 Oct, 2022
  • 18 locations
A Phase 2 Basket Study of the Oral TRK Inhibitor Larotrectinib in Subjects With NTRK Fusion-positive Tumors (NAVIGATE)

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is a drug that blocks the actions of these NTRK genes in cancer cells and can …

NTRK
tyrosine
lung cancer
breast cancer
measurable disease
  • 163 views
  • 21 Oct, 2022
  • 125 locations
Study Of NOVOTTF-200A In Bevacizumab-Naive Subjects With Recurrent Grade III Malignant Astrocytoma

This is a Phase 2 study in subjects with WHO Grade III Anaplastic Astrocytoma (G3 astrocytoma) who had progressive disease during first or second line treatment and who have not previously

bevacizumab
anaplastic astrocytoma
neutrophil count
platelet count
karnofsky performance status
  • 2 views
  • 27 Feb, 2022
  • 1 location
WSD0922-FU for the Treatment of Glioblastoma, Anaplastic Astrocytoma, or Non-small Cell Lung Cancer With Central Nervous System Metastases

Funding Source - FDA OOPD This phase I trial studies the side effects and best dose of WSD0922-FU for the treatment of glioblastoma, anaplastic astrocytoma, or non-small cell lung cancer

paclitaxel
gemcitabine
measurable disease
EGFR
brain metastases
  • 38 views
  • 04 Oct, 2022
  • 3 locations
Phase II Trial of Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory Glioblastoma Multiforme, Anaplastic Astrocytoma, and Anaplastic Oligoastrocytoma

Primary brain tumors are typically treated by surgery, radiation therapy and chemotherapy, either individually or in combination. Present therapies are inadequate, as evidenced by the low 5-year survival rate for brain cancer patients, with median survival at approximately 12 months. Glioma is the most common form of primary brain cancer, …

anaplastic oligoastrocytoma
beam radiation
EGFR
anaplastic astrocytoma
brain tumor
  • 283 views
  • 28 Oct, 2022
  • 1 location
HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM

Study to assess the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in newly diagnosed glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA).

anaplastic astrocytoma
platelet count
glioblastoma multiforme
valacyclovir
aptt
  • 35 views
  • 05 Mar, 2022
  • 1 location
Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA

The high-grade malignant brain tumors, glioblastoma multiforme (GBM) and anaplastic astrocytoma (AA), comprise the majority of all primary brain tumors in adults. This group of tumors also

bevacizumab
avastin
beam radiation
anaplastic astrocytoma
brain tumor
  • 146 views
  • 05 Nov, 2021
  • 1 location
A Study on -elemene as Maintain Treatment for Newly Diagnosed Malignant Gliomas

This study is being conducted to help determine whether -elemene as maintain treatment for complete remission patients of newly diagnosed malignant gliomas following standard treatment, is able to delay tumor growth, or impact how long people with newly diagnosed high-grade glioma.

  • 0 views
  • 22 Jan, 2021
  • 1 location