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Found 605 clinical trials
Transplacental Transmission of RSV (TTRSV)

Aim 1: To study transplacental transmission of Respiratory Syncytial Virus (RSV) and how this is moderated by other maternal infections during pregnancy Aim 2: To test maternal blood for presence of RSV-specific immunoglobulins and how this is moderated by other maternal infections during pregnancy Aim 3: To test cord blood …

Accepts healthy volunteers
fever
respiratory disease
sore throat
cough
  • 0 views
  • 24 Jul, 2022
  • 2 locations
Post-authorization Safety Study in North America to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy

The objective is to evaluate the potential effect of exposure to dupilumab in pregnancy compared to the primary comparison group of disease-matched pregnant women who are not exposed to dupilumab, and the secondary comparison group of healthy pregnant women. The primary outcome of the study is major structural defects, and …

asthma
dupilumab
Accepts healthy volunteers
  • 26 views
  • 18 Feb, 2022
  • 1 location
Immune Response Features in Allergic Airway Diseases

This study aims to investigate immune mechanisms and phenotypes and endotypes of allergic airway diseases - allergic rhinitis and allergic asthma. Pathogenesis of these diseases are not fully

house dust
Accepts healthy volunteers
nasal provocation test
rhinitis
asthma
  • 0 views
  • 05 Mar, 2022
  • 1 location
Respiratory Effects of Obesity in Children

, provokes dyspnea on exertion, or contributes to respiratory symptoms that could be misdiagnosed as asthma, placing obese children at risk of unnecessary treatment and potentially a reluctance to exercise

exercise test
Accepts healthy volunteers
  • 2 views
  • 12 Aug, 2022
  • 1 location
Improving Adherence to Controller Medication in Children With Asthma - the Unexplored Contribution of Behavioural Sciences (PACIFI)

Asthma is a common pediatric condition that can be well controlled with regular use of controller medications, however adherence to these is low, resulting in preventable exacerbations and

  • 0 views
  • 16 Sep, 2022
Effects of Pulmonary Diseases and Their Treatment on Cardiac Function

While the bidirectional relationship between the lung and the right heart are well studied, the cardiopulmonary interactions between the lung and the left heart are largely unresearched and not well understood. However, in recent years, there is a growing evidence that partially explains the bidirectional interaction between COPD and left …

COPD
pulmonary disease
  • 0 views
  • 05 Jul, 2022
  • 1 location
Measures of Respiratory Health (MRH) (MRH)

The Lung Clearance Index, measured by multiple breath washout, is a measure of lung function that is considered a research tool in Canada as the device used to measure it is not approved by Health Canada. The study will assess lung function in patients undergoing routine lung function testing for …

lung clearance index
pilocarpine
Accepts healthy volunteers
respiratory disease
fibrosis
  • 22 views
  • 26 May, 2022
  • 1 location
Respiratory Outcome of Infants With or Without Documented Wheezing During Bronchiolitis

Hospital admission for infant bronchiolitis is associated with an increased risk of recurrent wheezing and subsequent asthma in childhood. In the literature, 17 to 60% of children will develop

  • 0 views
  • 28 Oct, 2021
  • 1 location
Integrating Deep Learning CT-scan Model, Biological and Clinical Variables to Predict Severity of Asthma in Children (BREATHE)

very accurate task decision making. Recently, DL has shown promising results in assisting lung disease analysis using computed tomography (CT) images. Current severe asthma guidelines recommend

  • 0 views
  • 22 Mar, 2022
  • 1 location
Study of Hospitalised Patients With Acute Respiratory Conditions (CHESTY)

This observational study aim to characterise patients admitted to hospital with an acute respiratory condition, or acute worsening of their chronic lung condition. This will enable identification of predictors of future risk, as well as develop potential interventions targets.

Accepts healthy volunteers
  • 0 views
  • 15 Mar, 2022
  • 1 location