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Found 45 clinical trials
Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more …

asparaginase
lymphoid leukemia
combination chemotherapy
daunorubicin
cyclophosphamide
  • 1 views
  • 07 Nov, 2020
  • 5 locations
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. A donor stem cell transplant may replace the patient's immune cells …

asparaginase
lymphoid leukemia
combination chemotherapy
daunorubicin
graft-versus-tumor
  • 0 views
  • 07 Nov, 2020
  • 1 location
Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses

of native E.coli asparaginase and PEG-asparaginase during two treatment courses in the treatment of childhood lymphoblastic leukemia

asparaginase
lymphoid leukemia
pegaspargase
  • 9 views
  • 07 Nov, 2020
  • 1 location
Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase

This is a phase I/II clinical trial assessing the tolerability and efficacy of CM4620 in children and young adults with acute pancreatitis caused by asparaginase. The tolerability of CM4620 when

pancreatic necrosis
asparaginase
lipase
abdominal pain
toxicities
  • 0 views
  • 01 May, 2021
  • 1 location
Sintilimab in Combination With Chidamide in Refractory and Relapsed ENKTCL

-asparaginase regimens in several reports.We carried out a single, open-label, multicenter clinical trial enrolled patients with relapsed or refractory ENKTCL to safety and efficacy of sintilimab in

  • 3 views
  • 24 Mar, 2021
  • 4 locations
Anti-PD-1 Antibody Combined With Pegaspargase in the Treatment of Advanced Stage NK/T-cell Lymphoma

This open-label, single arm study will evaluate the efficacy and safety of anti-PD-1 antibody in combination with pegaspargase in treatment of newly diagnosed advanced stage NK/T-cell lymphoma.

  • 1 views
  • 23 Jan, 2021
  • 1 location
Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL)

The purpose of this study is to investigate the efficacy and safety for treating adult ALL patients with the pediatric protocol.

asparaginase
vincristine
lymphoid leukemia
adult acute lymphocytic leukemia
ejection fraction
  • 7 views
  • 07 Nov, 2020
  • 1 location
A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents

the optimal use of L-asparaginase (ASNase). It is known that administering ASNase results in the depletion of asparagine circulating in the blood, which starves the leukemic cells and results in their

asparaginase
lymphoid leukemia
induction therapy
pegaspargase
  • 0 views
  • 22 Jan, 2021
  • 28 locations
Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

. The purpose of Phase 2 of this study is to compare the rate of complete response (CR) of carfilzomib in combination with vincristine, dexamethasone, PEG asparaginase, daunorubicin (VXLD

  • 125 views
  • 16 May, 2021
  • 79 locations
Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised Targeted and Intensified Treatment

chemotherapy, risk adapted stem cell transplantation (SCT) and minimal residual disease (MRD) based individualised and intensified therapy. Study will further evaluate the role of asparaginase intensification

asparaginase
vincristine
b-cell acute lymphoblastic leukemia
daunorubicin
induction therapy
  • 12 views
  • 18 Apr, 2021
  • 1 location