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Found 113 clinical trials
Effects of Empagliflozin on Fibrosis and Cirrhosis in Chronic Hepatitis B

steatosis/inflammation, regress ascites (a cirrhotic complication), and improve liver function parameters and survival prognosis in terms of model for end-stage liver disease (MELD) score. There are

shear wave elastography
ascites
liver disease
steatosis
hepatitis
  • 0 views
  • 14 Jun, 2022
  • 1 location
Complete Cytoreduction Followed by IP and Systemic Chemotherapies for Gastric Cancer With Peritoneal Carcinomatosis (CRS-IP)

ascites, 1-year progression-free survival (PFS) and overall survival (OS), 3-year PFS and OS, and safety profiles. Based on Simon's minimax two-stage design, this trial will be carried out in two stages

cancer chemotherapy
capecitabine
gastrectomy
metastasis
adenocarcinoma
  • 0 views
  • 21 Mar, 2022
  • 1 location
Conversion Therapy of Hyperthermic Intraperitoneal Chemotherapy Plus Chemotherapy and Chemotherapy in Stage IV Gastric Cancer

The main purpose of this study is to compare Hyperthermic Intraperitoneal Chemotherapy combined with Chemotherapy and Chemotherapy as a conversion therapy for gastric Cancer Patients with peritoneal metastasis in Safety and Effectiveness.

cancer chemotherapy
gimeracil
neutrophil count
tegafur
metastasis
  • 0 views
  • 24 Mar, 2022
  • 1 location
Role of the ATP7A Transporter in Ovarian Cancer (ATHOC)

Ovarian cancer has the highest mortality rate among all gynecologic cancers, with most patients presenting with advanced stage tumors. About a third of patients do not respond to primary platinum-based chemotherapy treatment, and over time up to 80 % of others develop chemoresistance, rendering recurrent disease incurable. Despite all the …

cancer chemotherapy
ascites
platinum-based chemotherapy
carboplatin
cancer of the ovary
  • 0 views
  • 04 Oct, 2022
  • 1 location
Study of Fully Human B7H3 CAR-T in Treating Recurrent Malignant Ovarian Cancer

This is single center, open-label phase I, non-randomized study which will enroll patients with recurrent advanced ovarian cancer to evaluate the safety, feasibility, and efficacy of fully human B7H3 CAR-T cells (fhB7H3.CAR-Ts) via using a '3+3+3' dose escalation design. In the dose expansion cohort, six patients will be enrolled to …

cancer antigen 125
neutrophil count
cancer of the ovary
platelet count
measurable disease
  • 0 views
  • 25 Mar, 2022
  • 1 location
Effect of Branch Chain Amino Acid Therapy on Sarcopenia in Children With Chronic Liver Disease.

Sarcopenia is now a well-known complication of cirrhosis and various studies, including pediatric studies, have recognized it as a poor prognostic factor. At the molecular level, branch chain amino acids upregulate muscle protein synthesis by acting through the mTOR pathway. Although effect of Branch Chain Amino acids has been studied …

encephalopathy
muscle proteins
liver disease
cirrhosis
amino acids
  • 0 views
  • 11 Nov, 2021
  • 1 location
The Effect of Laparoscopic Splenectomy on Liver Reserve Function for Cirrhosis Patients (ELSL)

In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.

splenectomy
  • 0 views
  • 29 Apr, 2022
  • 1 location
The Effect of Laparoscopic Splenectomy and Azygoportal Disconnection on Liver Reserve Function for Cirrhosis Patients (ELSDL)

In this study, the investigators compared the improvement of liver reserve function related indicators in patients with liver cirrhosis after laparoscopic splenectomy and azygoportal disconnection. To determine whether surgical treatment can help enhance postoperative liver reserve function and improve patient prognosis.

splenectomy
  • 0 views
  • 29 Apr, 2022
  • 1 location
Body Composition Changes After TIPS and Associated Clinical Outcomes

The purpose of this study is to prospectively assess the impact of TIPS creation on muscle mass and physical function in patients with cirrhosis, and to determine whether these changes correlate with improved outcomes in patients awaiting liver transplantation. Retrospective observational studies have shown improvement in muscle mass and body …

hypertension
ascites
portosystemic shunt
cirrhosis
portal vein thrombosis
  • 0 views
  • 02 Jul, 2022
  • 1 location
Interest of Virtual Reality to Prevent Cancer Patient Anxiety Before Chemotherapy or an Invasive Act

The aim of the REV clinical trial is to evaluate the impact of a virtual reality exposure to decrease patient anxiety before chemotherapy or an invasive act. If positive, the access to virtual reality exposure is aimed to be used as standard of care at Lyon's hospital to improve cancer …

epirubicin
trastuzumab
docetaxel
immunomodulator
adjuvant chemotherapy
  • 0 views
  • 21 Jul, 2021
  • 1 location