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Found 4 clinical trials
Asciminib in Monotherapy for Chronic Myeloid Leukemia in Chronic Phase (CML-CP) With and Without T315I Mutation

This study will be a multicenter Phase IIIb open-label, three-cohort study of asciminib in patients with CML-CP without T315I mutation who have had at least 2 prior TKIs and CML-CP harboring the

  • 0 views
  • 14 Jul, 2021
  • 4 locations
Study of Efficacy and Safety of Asciminib in Combination With Imatinib in Patients With Chronic Myeloid Leukemia in Chronic Phase (CML-CP)

To evaluate efficacy, safety and pharmacokinetic profile of asciminib 40mg+imatinib or asciminib 60mg+imatinib versus continued imatinib and versus nilotinib in pre-treated patients with Chronic

imatinib
potassium
neutrophil count
chronic myeloid leukemia
gilbert's syndrome
  • 62 views
  • 25 Jul, 2021
  • 50 locations
Frontline Asciminib Combination in Chronic Phase CML

respective cohort. All patients must provide written informed consent to be enrolled in the trial. Cohorts were designed to allow assessment of QD and BID asciminib based combinations to optimize quality of

imatinib
potassium
dasatinib 100 mg
hydroxyurea
philadelphia chromosome
  • 0 views
  • 02 Feb, 2021
  • 37 locations
ABL001 for the Treatment of Chronic Myeloid Leukemia in Patients Who Are on Therapy With Tyrosine Kinase Inhibitor

This phase II trial studies how well ABL001 works in treating patients with chronic myeloid leukemia who are on therapy with tyrosine kinase inhibitor. ABL001 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving ABL001 and tyrosine kinase inhibitor together may …

  • 0 views
  • 26 Jan, 2021