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Found 1016 clinical trials
Development of Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD)

This protocol focuses on novel measures of cognition and everyday function that have robust psychometrics and reduced practiced effects. They will be deployed in a parallel group study in which participants are randomized to assessment type (novel vs established) and receive serial assessments over a one year period in order …

Accepts healthy volunteers
  • 102 views
  • 04 Oct, 2022
  • 4 locations
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

Background Human immunodeficiency virus (HIV) is treated with antiretroviral drugs. Many people with HIV also have the lung infection tuberculosis (TB). Most TB treatments are complicated. A simpler treatment of two TB drugs can be taken once a week. Researchers want to study how the HIV and TB drugs affect …

blood test
cervical cap
Accepts healthy volunteers
fasting
vitamins
  • 9 views
  • 04 Oct, 2022
  • 1 location
Understanding the Acute Modulation of Brain Activity by Transcranial Magnetic Stimulation

Background Transcranial magnetic stimulation (TMS) is form of non-invasive brain stimulation. It is approved to treat depression. TMS may help decrease drug craving. It is important to understand how TMS affects the brain. Such a better understanding would help to design ways to treat drug addiction. Objectives To learn how …

Accepts healthy volunteers
fasting
  • 100 views
  • 10 Oct, 2022
  • 1 location
A Randomized, Sponsor-Open, Adaptive, Single- And Multiple-Ascending Dose, Placebo-Controlled Study To Investigate The Safety, Tolerability, And Pharmacokinetics Of RO7223280 Following Intravenous Administration In Healthy Participants

The Study consists of 3 Parts: Part 1 (Single Ascending Dose/SAD), Part 2 (Multiple Ascending Dose/MAD), and Part 3 (Elderly). Part 1 will investigate the safety, tolerability and PK of single-ascending intravenous (IV) doses of RO7223280 in healthy participants. Part 2 will investigate the safety, tolerability and PK of multiple-ascending …

Accepts healthy volunteers
  • 0 views
  • 10 Oct, 2022
  • 1 location
Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults (PROSCEA)

It is now widely accepted that autism is linked to a developmental disorder and cerebral function. Our research team (UMR U930 INSERM, François-Rabelais University of Tours, whom Pr F Bonnet-Brilhault is responsible for team "Autism") hypothesizes that atypical sensory information processing, especially auditory and / or visual information, could underly …

Accepts healthy volunteers
  • 7 views
  • 07 Oct, 2022
  • 1 location
A Study to Assess Safety, Tolerability, Pharmacokinetics (PK), Immunogenicity, and Pharmacodynamics (PD) of Intravenous Infusions of E2814 in Healthy Participants

The primary objective of this study is to evaluate the safety and tolerability of single and multiple intravenous infusions of E2814 in healthy adult participants.

Accepts healthy volunteers
  • 350 views
  • 04 Oct, 2022
  • 2 locations
Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Healthy Volunteers

Background Rivaroxaban and apixaban are blood thinners. People with HIV may need to take them to treat or prevent blood clots. The anti-HIV drug darunavir (DRV) can increase the amount of these blood thinners in the body. This can cause bleeding or other health problems. The drug cobicistat (COBI) is …

blood test
body mass index
Accepts healthy volunteers
fasting
  • 6 views
  • 28 Oct, 2022
  • 1 location
The Efficacy of Cryotherapy in Pregnancy Related Pelvic Girdle Pain

The findings from this project may result in pain reduction and improved mobility in pregnant women with pelvic girdle pain in their second and third trimester.

  • 93 views
  • 21 Apr, 2022
  • 1 location
Can Flaxseed Prevent Broken Hearts in Women With Breast Cancer Study?

The main goal of the current research program is to examine the use of nutraceuticals, in particular flaxseed (FLX), in the prevention of Doxorubicin and Trastuzumab (DOX+TRZ) mediated cardiotoxicity in the clinical setting. As Manitoba continues to be one of the top FLX producers in the world, there is an …

  • 4 views
  • 26 Jan, 2021
  • 1 location
Sensori-motor and Perceptual Functions of the PPC. (PPCfonctions)

To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these …

Accepts healthy volunteers
  • 2 views
  • 26 Feb, 2022
  • 1 location