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Found 1043 clinical trials
lncRNAs as a Biomarker to Assess the Therapeutic Impact of Oral Absorbent Probiotics in CKD Patients With PAD

Participants with chronic kidney disease (CKD) are at a higher risk of developing atherosclerotic peripheral artery disease (PAD). Retention of uremic toxins such as indoxyl sulfate (IS), p-cresyl sulfate (PCS) and trimethylamine N-oxide (TMAO) during CKD is detrimental to endothelial and vascular function and can predispose to the development and …

  • 0 views
  • 15 Mar, 2021
  • 1 location
Tracking Information Flow in the Brain (BRAINDYN)

The brain is composed of a set of areas specialized in specific computations whose outputs need to be transferred to other specialized areas for cognition to emerge. To account for context-dependent behaviors, the information must be flexibly routed through the fixed anatomy of the brain. The aim of this project …

Accepts healthy volunteers
  • 4 views
  • 24 May, 2022
  • 1 location
Mind-body Awareness Training and Brain-computer Interface

Mind-Body Awareness Training (MBAT), in the forms of various yoga and meditative practices, has become increasingly prevalent due to an increase in awareness of the potential health benefits, and improvements in concentration that this training can provide to practitioners. In the present study, the role of Mind-Body Awareness Training (MBAT) …

Accepts healthy volunteers
  • 26 views
  • 28 Jul, 2022
  • 1 location
Investigation of the Gut Microbiome and Statin Response (INGEST)

There is evidence that the bacteria that naturally reside in the gut can influence how well we respond to medications. Therefore this study will look at how rosuvastatin, a medication used to lower cholesterol levels, may change the bacteria in the gut. Investigators will also examine how the gut bacteria …

Accepts healthy volunteers
  • 115 views
  • 29 May, 2022
  • 1 location
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

Background Human immunodeficiency virus (HIV) is treated with antiretroviral drugs. Many people with HIV also have the lung infection tuberculosis (TB). Most TB treatments are complicated. A simpler treatment of two TB drugs can be taken once a week. Researchers want to study how the HIV and TB drugs affect …

Accepts healthy volunteers
fasting
vitamins
cervical cap
blood test
  • 9 views
  • 26 Jul, 2022
  • 1 location
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Bioavailability, and Food-effects of EA1080 in Healthy Caucasian and Japanese Male Participants

The primary purpose of the study is to evaluate the safety and tolerability of EA1080 following single and multiple ascending oral doses in healthy Caucasian and Japanese male participants.

body mass index
Accepts healthy volunteers
  • 19 views
  • 25 Jul, 2022
  • 1 location
Development of Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD)

This protocol focuses on novel measures of cognition and everyday function that have robust psychometrics and reduced practiced effects. They will be deployed in a parallel group study in which participants are randomized to assessment type (novel vs established) and receive serial assessments over a one year period in order …

Accepts healthy volunteers
  • 102 views
  • 25 Jul, 2022
  • 4 locations
Collection of PBMCs From Healthy Subjects for the Development of Cellular Immunotherapy Product

Title: Collection of Peripheral Blood Mononuclear Cells (PBMCs) From Healthy Subjects for the Development of Cellular Immunotherapy Product Background CAR-T therapies are being developed that utilize modified immune cells to fight tumors. 'Off-the-shelf' allogeneic CAR-T technology has better efficacy and more promising clinical applications. Investigators want to use the cells …

Accepts healthy volunteers
  • 4 views
  • 01 Mar, 2022
  • 1 location
Brain Effect of Vagal Nerve Stimulation at Rest and Pain

Pain is a ubiquitous distressing sensory experience and is the most frequent symptom in numerous gastrointestinal disorders including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Visceral pain is especially difficult to treat with conventional medications and new treatments are needed. Recently, the relationship between autonomic nerve system (ANS) …

Accepts healthy volunteers
  • 250 views
  • 02 Mar, 2022
  • 1 location
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIIB107 in Healthy Adult Participants

The primary objective is to determine the safety and tolerability of single and multiple ascending subcutaneous (SC) doses and single ascending intravenous (IV) doses of BIIB107 in healthy adult participants. The secondary objectives are to characterize the single-dose pharmacokinetic (PK) of SC and IV BIIB107 in healthy adult participants and …

Accepts healthy volunteers
  • 0 views
  • 28 Apr, 2022
  • 2 locations