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Found 1105 clinical trials
Protection Against Emboli During Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE-II)

A prospective, multicenter single-arm, open label study to evaluate the safety and effectiveness of the Neuroguard IEP System for the treatment of carotid artery stenosis in subjects at elevated risk for adverse events following carotid endarterectomy (CEA). The Neuroguard IEP System is a 3-in-1 carotid stent delivery system consisting of …

neck surgery
aneurysm repair
ischemic attack
vascular surgery
angiography
  • 0 views
  • 05 Jun, 2022
  • 7 locations
Safety and Efficacy of the CGuard™ Carotid Stent System in Carotid Artery Stenting (C-Guardians)

The objective of this pivotal study is to evaluate the safety and efficacy of the CGuard™ Carotid Stent System in the treatment of carotid artery stenosis in symptomatic and asymptomatic patients undergoing carotid artery stenting (CAS) to a performance goal developed from published CAS literature.

stenosis
carotid artery stenosis
  • 0 views
  • 14 Jul, 2022
  • 17 locations
Effect of Remote Ischemic Preconditioning on Cerebral Circulation Time in Patients With Severe Carotid Artery Stenosis (RIP-CCT)

Cerebral circulation time in patients with severe carotid artery stenosis was found to be associated with hyperperfusion syndrome. Remote ischemic preconditioning can change the ability of cerebral autoregulation. The prospective, randomized controlled, blind outcome evaluation, multi-center study aimed to investigate the effect of remote ischemic preconditioning on cerebral circulation time …

  • 0 views
  • 21 Jul, 2022
  • 1 location
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-2)

The purpose of this study is to evaluate whether intramuscular injections of NL003 into the calf is safe and effective in the treatment of critical limb ischemia

ischemic ulcer
critical limb ischemia
gangrene
stenosis
ischemia
  • 2 views
  • 20 Apr, 2022
  • 12 locations
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia (NL003-CLI-III-1)

To evaluate the safety and efficacy of recombinant human hepatocyte growth factor (HGF) bare plasmid injection for local intramuscular injection in the treatment of patients with severe lower limb hemorrhagic disease (Rutherford grade 4)

ischemia
critical limb ischemia
hepatocyte growth factor
gene therapy
stenosis
  • 9 views
  • 22 Apr, 2022
  • 11 locations
Ciclosporin A Preconditioning for Renal Artery Stenosis (CicloSAAR)

Renal artery stenosis is one the leading cause of secondary hypertension. Previous randomized controlled trials in humans have failed to demonstrate an improvement of renal function after stenosis dilation, probably because of a selection bias with more severe patients being excluded from randomization. Renal ischemia-reperfusion injuries have also not been …

renal artery stenosis
mitochondrial permeability transition pore
MRI
stenosis
ciclosporin a
  • 6 views
  • 21 Mar, 2022
  • 1 location
Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke Risk

Stroke is a leading cause of death and disability in the United States and around the world. The goal of this work is to develop and test a noninvasive ultrasound-based imaging technology to better identify patients at high risk of stroke so that appropriate and timely intervention may be administered …

stenotic
stroke
endarterectomy
  • 0 views
  • 14 May, 2022
  • 1 location
ACtive Catheterization for EndovaScular TreatmentS (ACCESS)

The objective of this clinical investigation is to evaluate the safety and technical success of the Basecamp Vascular controllable directional GECKO guidewire when used to facilitate endovascular access to the targeted vessel in order to treat the vascular lesion.

  • 0 views
  • 28 Jul, 2022
  • 1 location
The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which …

ischemic ulcer
critical limb ischemia
arterial disease
Accepts healthy volunteers
gangrene
  • 16 views
  • 16 Mar, 2022
  • 2 locations
Endovascular Acute Stroke Intervention - Tandem OCclusion Trial

Patients with tandem occlusion or tandem lesion (TL), that is, stroke with an acute intracranial anterior circulation occlusion and an ipsilateral cervical ICA (c-ICA) high-grade stenosis or occlusion, constitute about 15-20% of patients undergoing endovascular thrombectomy (EVT). However, the optimal treatment of acute stroke patients with TL remains uncertain, as …

stroke
acute stroke
probe
deficit
heparin
  • 1 views
  • 13 Aug, 2021
  • 1 location