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Found 831 clinical trials
Subclinical AtrIal FibrilLation and StrokE PreveNtion Trial

Introduction: Patients with atrial fibrillation (AF) have a substantial risk of stroke and systemic embolism. Subclinical AF is often suspected to be the cause of stroke in these patients. The detection of asymptomatic AF episodes is a challenge and the real rate of occurrence of these episodes remains unknown. The …

fibrillation
infarct
stroke
embolism
anticoagulation therapy
  • 0 views
  • 11 Sep, 2021
  • 1 location
STrategies for Catheter Ablation of peRsistent Atrial Fibrlllation (STARAF3)

The objective of this study is to compare the efficacy of three different ablation strategies in patients with persistent AF: PV antral isolation alone (PVAI) PV antral isolation plus ablation of drivers (PVAI+drivers) PV antral isolation plus isolation of posterior wall (PVAI+box) All three strategies will employ contemporary catheter ablation …

electrocardiogram
catheter ablation
antiarrhythmic drug
left ventricular dysfunction
  • 0 views
  • 05 Jul, 2022
  • 1 location
Early Dronedarone Versus Usual Care to Improve Outcomes in Persons With Newly Diagnosed Atrial Fibrillation (CHANGE-AFIB)

While there are several completed clinical trials that address treatment strategy in patients with symptomatic and recurrent AF, there are no randomized clinical trials that address treatment for first-detected AF. In usual care, these patients are started on an atrioventricular nodal blocking agent (beta-blocker or non-dihydropyridine calcium channel blocker) along …

fibrillation
vascular disease
antiarrhythmic drug
beta blockers
stroke
  • 0 views
  • 25 Jul, 2022
  • 13 locations
Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF) (COP-AF)

The prevention of perioperative atrial fibrillation has the potential to reduce mortality, stroke, and hospital stays in patients undergoing thoracic surgery. Data from cardiac surgery patients suggest that prevention of perioperative atrial fibrillation using an anti-inflammatory agent, such as colchicine, is feasible. The COP-AF trial will assess whether the administration …

fibrillation
heart surgery
anesthesia
stroke
anti-inflammatory agent
  • 83 views
  • 01 Feb, 2022
  • 28 locations
Left Atrium Appendage Closure by Surgery-2

Atrial fibrillation is a heart rhythm disorder that often occurs after heart surgery. During atrial fibrillation blood cloths may form, predominantly in the left atrial appendage, a small sac in the wall of the left side of the heart. Some heart surgeons close this appendage to protect against stroke, particularly …

fibrillation
heart surgery
traumatic brain injury
left atrial appendage closure
stroke
  • 0 views
  • 30 Apr, 2021
  • 6 locations
Left Atrial Appendage Occlusion for AF Patients Unable to Use Oral Anticoagulation Therapy

Up to 5% of Atrial Fibrillation (AF) patients may have or develop contraindications to use oral anticoagulation (OAC). Randomized controlled trial (RCT) data suggest that Left Atrial Appendage Occlusion (LAAO) may provide a non-inferior alternative for cardioembolic stroke protection in patients tolerant to OAC. However, RCT data for LAAO is …

fibrillation
vascular disease
left atrial appendage occlusion
stroke
anticoagulation therapy
  • 0 views
  • 28 Sep, 2021
  • 14 locations
Bariatric Atrial Restoration of Sinus Rhythm (BAROS)

The objective of this study is to determine whether bariatric surgery followed by Atrial Fibrillation (AF) catheter ablation is superior to AF catheter ablation alone in the management of atrial fibrillation in patients with morbid obesity.

fibrillation
steatosis
arthropathy
diabetes
hyperlipidemia
  • 0 views
  • 03 Mar, 2022
  • 1 location
OPTIMAS: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial (OPTIMAS)

OPTIMAS is a large, prospective, partially blinded randomised controlled trial of early (within 4 days [96hrs]) or standard (between day 7 and day 14 after stroke onset) initiation of anticoagulation after stroke in patients with atrial fibrillation (AF), using any licensed dose of a direct oral anticoagulant (DOAC). The trial …

electrocardiographic monitoring
fibrillation
ischemic stroke
12 lead ECG
anticoagulation therapy
  • 76 views
  • 20 Feb, 2022
  • 44 locations
Optimal Detection of Atrial Fibrillation in TIA (ODEA-TIA)

Transient ischemic attack (TIA) is a common neurologic emergency. Although the detection of atrial fibrillation (AF) has identical consequences for preventive therapy in patients with ischemic stroke and TIA, the management setting and diagnostic pathways frequently differ substantially between both manifestations. Despite these differences between stroke and TIA patients, previous …

electrocardiographic monitoring
fibrillation
brain infarction
transient ischemic attack
infarct
  • 1 views
  • 27 Feb, 2022
  • 2 locations
Left Atrial Appendage Occlusion Versus Novel Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation (Occlusion-AF)

Atrial fibrillation (AF) is progressively common, and increases the risk of stroke five-fold. Oral anticoagulation is the mainstay therapy; however, it increases the risk of bleeding. Moreover, 30% with AF and at risk of stroke are not in relevant anticoagulation. The randomized PROTECT-AF trial has demonstrated the superiority of left …

fibrillation
apixaban
warfarin
cerebral infarction
edoxaban
  • 9 views
  • 13 Feb, 2022
  • 7 locations