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Found 33 clinical trials
Biomarker Driven Intensified ChemoImmunotherapy With Early CNS Prophylaxis

This study is testing whether stratification of the patients according to biological risk factors for different treatment groups will improve the outcome of patients with clinically high diffuse large B-cell lymphoma (DLBCL).

chemoimmunotherapy
t-cell lymphoma
follicular lymphoma
burkitt's lymphoma
large cell lymphoma
  • 32 views
  • 23 Jan, 2021
  • 18 locations
Efficacy of R-CHOP vs R-CHOP/R-DHAP in Untreated MCL

followed by total body irradiation [TBI]/high dose cytarabine [ARA-C]/melphalan-peripheral blood stem cell transplantation (TAM-PBSCT) can improve the time to treatment failure compared to CHOP

granulocyte colony stimulating factor
etoposide
cytarabine
high dose chemotherapy
ara-c
  • 134 views
  • 07 Nov, 2020
  • 2 locations
BREntuximab Vedotin in SEcond LIne Therapy BEfore Transplant

A Randomized Phase IIb Study, Evaluating Efficacy of Salvage Therapy with Brentuximab Vedotin-ESHAP vs ESHAP in Patients with Relapsed / Refractory Classical Hodgkin's Lymphoma, Followed by Brentuximab Vedotin Consolidation (instead of Autologous Hematopoietic Stem Cell Transplantation) in Those who Attained a Metabolic Complete Remission after Salvage Therapy

  • 0 views
  • 27 Jan, 2021
  • 19 locations
Treatment of Acute Lymphoblastic Leukemia Ph '(BCR / ABL) Positive Patients Aged > 55 Years

This study proposes to provide adequate treatment and is based on current scientific evidence for elderly patients with ALL Bcr / Abl positive. To determine whether low-dose chemotherapy associated with imatinib or dasatinib has acceptable tolerability in elderly patients. To determine whether this association can increase the rate and quality …

  • 1 views
  • 28 Jan, 2021
  • 1 location
Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE

20-25% of patients over 15 years with acute lymphoblastic leukemia (ALL) have the Philadelphia chromosome or BCR-ABL rearrangement. Traditionally, intensive chemotherapy followed by hematopoietic stem cell transplantation (HSCT) have formed the basis allogeneic treatment of this disease, but the results have been poor (60-75% complete remissions-RC-and probability of long-term survival …

  • 103 views
  • 03 Feb, 2021
  • 112 locations
ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

The primary objective of the the trial is to establish one of three study arms, as future standard based on the comparison of the investigator-assessed failure-free survival.

granulocyte colony stimulating factor
bone marrow infiltration
etoposide
cytarabine
ara-c
  • 64 views
  • 21 Jan, 2021
  • 80 locations
International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia

combined with induction chemotherapy. To compare two consolidation regimens: high dose cytarabine (HD Ara-C) and fludarabine & cytarabine (FLA) in standard risk patients. To compare

myeloablative conditioning
fludarabine
blast cells
flow cytometry
gilbert's syndrome
  • 0 views
  • 26 Jan, 2021
  • 59 locations
Trial to Test the Effects of Adding 1 of 2 New Treatment Agents to Commonly Used Chemotherapy Combinations

> At entry, a randomisation will compare a standard chemotherapy schedule DA (Daunorubicin/Ara-C) combined with 1 dose of Mylotarg (gemtuzumab ozogamicin, or GO) in course 1 against CPX-351

high risk myelodysplastic syndrome
myeloid leukemia
blast cells
azacitidine
leukemia
  • 381 views
  • 23 Jan, 2021
  • 83 locations
Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

RATIONALE: Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow …

antithymocyte globulin
prednisone
thioguanine
etoposide
asparaginase
  • 12 views
  • 23 Jan, 2021
  • 5 locations
Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

This phase III trial studies response-based chemotherapy in treating newly diagnosed acute myeloid leukemia or myelodysplastic syndrome in younger patients with Down syndrome. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by …

bone marrow procedure
myeloproliferative disorder
etoposide
myeloid leukemia
cytarabine
  • 153 views
  • 27 Mar, 2021
  • 140 locations