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Found 24 clinical trials
Brain Energy for Amyloid Transformation in Alzheimer's Disease Study (BEAT-AD)

The Brain Energy for Amyloid Transformation in AD (Alzheimer's disease) or BEAT-AD study will compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment. The data collected will help determine whether diet interventions induce changes in cognitive function, cerebral blood flow, and …

cognitive impairment
amyloidosis
mild cognitive impairment
alzheimer's disease
cognitive assessment
  • 10 views
  • 14 Jun, 2022
  • 1 location
CYCLE-AD (CYcling to Cease or Limit the Effects of Alzheimer's Disease) (CYCLE AD)

The overall goal of the CYCLE-AD trial is to determine the role of long-term, high intensity exercise in slowing or delaying the onset of cognitive and AD-related brain changes in e4 carriers. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing or delaying …

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Information About Alzheimer's Disease for Latinos in New York City (IDEAL)

This study will assess the psychosocial and behavioral impacts of receiving Alzheimer's disease genetic risk assessment incorporating APOE genotypes among Latinos in northern Manhattan. The investigators will conduct a longitudinal, community-based study with a mixed methods design. Participants will be randomized to learn about their lifetime risk of late-onset Alzheimer's …

cognitive assessment
alzheimer's disease
  • 0 views
  • 24 Mar, 2022
  • 1 location
Effects of a High EPA Multinutrient Supplement on Negative Affect in Young Adults. (NutriMOOD)

This is a 12-week-long, randomised, double-blind, placebo-controlled trial exploring the efficacy of a high-EPA multinutrient supplement in the management of sub-clinical anxiety and depression. The investigators focus on young and healthy, adult university students, who may otherwise not be eligible for pharmacological or cognitive behavioural therapy interventions.

depressed mood
anxiety
behavior therapy
Accepts healthy volunteers
  • 1 views
  • 05 Jun, 2022
  • 1 location
Late Onset Alzheimer's Disease (LOAD)

The goal of this study is to is to focus on the genetic influences on Alzheimer's Disease (AD) risk. The investigators are looking for families and/or individuals (affected or unaffected) of any ethic background (African American, Caucasian, and Hispanics) with a family history of AD and willing to participate.

Accepts healthy volunteers
dementia
dementia, frontotemporal
alzheimer's disease
  • 0 views
  • 19 Oct, 2022
  • 12 locations
Defining the Genetic Etiology of Alzheimer's Disease in the Faroe Islands

The investigators established the Faroese Alzheimer's Cohort with the aim to unravel genetic and environmental factors that influence the risk and/or susceptibility of Alzheimers disease (AD). It is believed the Faroese population represents a unique opportunity due to its characteristics as a geographic, environmental and genetic isolate with a homogeneous …

Accepts healthy volunteers
dementia
alzheimer's disease
  • 5 views
  • 12 Feb, 2022
  • 1 location
Vanderbilt Memory and Aging Project (VMAP)

This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults. Adjusting for relevant clinical covariates, we will test the hypothesis that vascular health is associated with clinical, brain magnetic resonance …

cognitive impairment
mild cognitive impairment
alzheimer's disease
dementia
cognitive decline
  • 18 views
  • 27 May, 2022
  • 1 location
Study of the Effect of Innate Immunity on the Inflammatory Response to Endotoxin

Background Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to …

diabetes
Accepts healthy volunteers
asthma
  • 18 views
  • 21 Oct, 2022
  • 1 location
Intelligent Digital Tools for Screening of Brain Connectivity and Dementia Risk Estimation in People Affected by Mild Cognitive Impairment (AI-Mind)

Every three seconds someone in the world develops dementia. There are over 50 million people worldwide living with dementia and by 2030 this figure is expected to reach 82 million. Besides time-consuming patient investigations with low discriminative power for dementia risk, current treatment options focus on late symptom management. By …

mini-mental state examination
cognitive impairment
dementia
mild cognitive impairment
  • 0 views
  • 25 Jan, 2022
  • 5 locations
Predictors of Better Outcomes After Severe Acquired Brain Injuries

Severe Acquired Brain Injury is defined as a traumatic, post-anoxic, vascular or other brain damage that causes coma for at least 24 hours and leads to permanent disability with sensorial, motor, cognitive or compartmental impairment. In this context, an accurate characterization of individual patients' profile in terms of neuronal damage, …

coma
  • 7 views
  • 24 Jan, 2021
  • 1 location