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Found 24 clinical trials
Featured trial
Valacyclovir for Mild Cognitive Impairment (VALMCI)

Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic mild cognitive impairment (MCI) patients (eMCI and lMCI). The trial will directly address the long-standing viral etiology hypothesis of Alzheimer's disease (AD) which posits …

  • 21 views
  • 08 Sep, 2022
  • 1 location
Featured trial
A 26-Week, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Effects of Daily Administration of AC-1204 in Participants With Mild to Moderate Alzheimer's Disease (AD) With an Optional 26-Week Open Label Extension

A 26-Week, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Effects of Daily Administration of AC-1204 in Participants With Mild to Moderate Alzheimer's Disease (AD) With an Optional 26-Week Open Label Extension

  • 171 views
  • 08 Dec, 2020
  • 1 location
Epileptiform Activity During REM Sleep in Alzheimer's Disease (EREMAD)

scans) and in the case of patients, the phenotype of the Apolipoprotein E(ApoE) gene.

Accepts healthy volunteers
polysomnography
mental state examination
mini-mental state examination
apolipoprotein e
  • 0 views
  • 23 Jan, 2022
  • 1 location
Exercise for Brain Health in the Fight Against Alzheimer's Disease

, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-4) allele carriers are known to be at substantially greater risk

Accepts healthy volunteers
  • 165 views
  • 16 Feb, 2022
  • 1 location
'Oral Microbiome -Dietary Nitrate' Interactions and Cognitive Health in Older Age (COGNIT)

Vegetable rich diets contain natural inorganic nitrate. These diets are linked to good heart and brain health. Human cells cannot 'activate' nitrate. Humans must rely on specific bacteria living in the mouth to digest nitrate to an active form called 'nitric oxide' that we can use in the body. We …

Accepts healthy volunteers
  • 0 views
  • 15 Sep, 2022
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism (HYPOCHOL)

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

  • 0 views
  • 24 Feb, 2022
  • 1 location
Statins In Intracerbral Hemorrhage

to continue/discontinue statins should be influenced by an individual's Apolipoprotein-E (APOE) genotype.

  • 0 views
  • 30 Jul, 2021
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain

High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called …

alzheimer's disease
Accepts healthy volunteers
apolipoprotein e
  • 5 views
  • 24 Jan, 2022
  • 1 location
Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults

endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) 4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.

Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 1 location
Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects

The overall objective of this study is to compare the overall pattern of [18F]APN-1607 uptake in subjects with MDAD, subjects with AD dementia, and healthy subjects.

dementia
cognitive impairment
amyloid
cognitive assessment
Accepts healthy volunteers
  • 8 views
  • 09 May, 2022
  • 1 location