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Found 27 clinical trials
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A 26-Week, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Effects of Daily Administration of AC-1204 in Participants With Mild to Moderate Alzheimer's Disease (AD) With an Optional 26-Week Open Label Extension

A 26-Week, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Effects of Daily Administration of AC-1204 in Participants With Mild to Moderate Alzheimer's Disease (AD) With an Optional 26-Week Open Label Extension

  • 163 views
  • 08 Dec, 2020
  • 1 location
Exercise for Brain Health in the Fight Against Alzheimer's Disease

, cognition, and physical function in cognitively healthy and physically inactive older adults (ages 60-80). Apolipoprotein E epsilon4 (APOE-4) allele carriers are known to be at substantially greater risk

Accepts healthy volunteers
  • 165 views
  • 16 Feb, 2022
  • 1 location
Epileptiform Activity During REM Sleep in Alzheimer's Disease (EREMAD)

scans) and in the case of patients, the phenotype of the Apolipoprotein E(ApoE) gene.

mini-mental state examination
apolipoprotein e
polysomnography
mental state examination
Accepts healthy volunteers
  • 0 views
  • 23 Jan, 2022
  • 1 location
Predicting Postoperative Delirium Using EEG, Genetics and Neurobiomarkers of Cerebral Injury (POD-01)

(EEG), under general anesthesia, is associated with the occurrence of POD, and whether specific patterns worrelate with the patient's preoperative cognitive status. As apolipoprotein E (APOE

cardiopulmonary bypass
electroencephalogram
cerebral injury
intraoperative eeg
heart surgery
  • 0 views
  • 06 May, 2022
  • 1 location
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism (HYPOCHOL)

The aim of this study is to identify new targets in cholesterol metabolism thanks to a genetically-based strategy.

  • 0 views
  • 24 Feb, 2022
  • 1 location
Statins In Intracerbral Hemorrhage

to continue/discontinue statins should be influenced by an individual's Apolipoprotein-E (APOE) genotype.

  • 0 views
  • 30 Jul, 2021
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain

High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF. The investigators propose to further study this phenomenon with a clinical study to assess cerebral blood flow which can be measured by a technique called …

Accepts healthy volunteers
apolipoprotein e
alzheimer's disease
  • 5 views
  • 24 Jan, 2022
  • 1 location
Temporal Relations and Exercise Interventions of Various Gait and Cognitive Domains in Older Adults

endothelial growth factor (VEGF) and expression of the apolipoprotein E (APOE) 4 allele parallel changes in gait characteristics and cognitive functions after the intervention will be examined.

Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 1 location
Plasma P-tau2017 and Quantitative Amyloid PET Imaging

The overall goal of this protocol is to compare amyloid burden assessed by amyloid PET to plasma P-tau217 levels.

amyloid
Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 1 location
Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects

The overall objective of this study is to compare the overall pattern of [18F]APN-1607 uptake in subjects with MDAD, subjects with AD dementia, and healthy subjects.

cognitive impairment
oophorectomy
amyloidosis
cognitive assessment
dementia
  • 7 views
  • 09 May, 2022
  • 1 location