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Found 51 clinical trials
Loop Gain in the Reversion of OSA Treated by Either CPAP or Cardiac Valve Replacement

Sleep apnea including obstructive sleep apnea (OSA) and central sleep apnea (CSA), are common in patients with cardiovascular disease. The prevalence of OSA is 2%-4% in general population and 16%-47% in surgical-heart failure patients. The previous studies found that the sleep apnea types shifted from OSA to CSA after continuous …

valvular disease
heart disease
cardiovascular disease
heart surgery
heart failure
  • 0 views
  • 28 Feb, 2022
  • 1 location
Use of RCMP to Predict Treatment Outcomes of Maxillomandibular Advancement Surgery for OSA

Maxillomandibular advancement (MMA) surgery, one of the most successful surgical procedures for the treatment of obstructive sleep apnea (OSA), is predominantly used to manage patients with moderate to severe OSA. However, limiting factors include incomplete response in some cases, unfavorable facial changes as a result of large advancements, and risk …

oral appliances
polysomnography
  • 0 views
  • 21 Oct, 2021
  • 1 location
Domiciliary Transcutaneous Electrical Stimulation in Obstructive Sleep Apnoea (TESLA-home)

The aim of this study is to assess the efficacy of transcutaneous electrical stimulation of the pharyngeal dilator muscles in patients with obstructive sleep apnoea in the community compared to usual care, and follow the patients for three months, as well as to assess compliance of non-invasive electrical stimulation of …

obstruction
continuous positive airway pressure
body mass index
  • 68 views
  • 04 Mar, 2022
  • 1 location
Prospective Randomized Trial of CPAP for SDB in Patients Who Use Opioids

Patients with chronic pain who use opioids appear to be at increased risk for breathing issues during sleep, termed sleep disordered breathing (SDB). Treatment of SDB often consists of use of a device during sleep that provides continuous positive airway pressure (CPAP) via a mask interface. The goal of this …

chronic pain
apnea
opioid use
apnea-hypopnea index
opioid
  • 0 views
  • 28 Nov, 2021
  • 1 location
Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment (CSA)

Central sleep apnea (CSA) is common in patients with heart failure and those using opioid analgesics. Unfortunately, effective treatment of central apnea remains elusive, pressure therapy given the modest efficiency of positive airway pressure therapy. The focus of this proposal is to identify mechanistic pathways to guide future therapeutic interventions …

opioid
apnea-hypopnea index
Accepts healthy volunteers
central sleep apnea
heart failure
  • 0 views
  • 23 Mar, 2022
  • 1 location
Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure. (HO2F)

The aims of this study are to 1) determine the optimal levels of O2 flow which prevent nocturnal O2 desaturation while minimizing periods of hyperoxia during the course of nocturnal oxygen therapy (NOXT) in heart failure patients with reduced ejection fraction (HFrEF) patients with CSA/CSR; 2) document whether within-patient EO2F …

apnea
ejection fraction
heart disease
central sleep apnea
heart failure
  • 11 views
  • 25 Apr, 2022
  • 2 locations
Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Obstructive sleep apnea (OSA) is common in older adults and has recently been implicated in pathogenesis of Alzheimer's disease (AD). Research has shown that sleep disruptions have caused memory impairment. Sleep apnea is a form of sleep disruption. We would like to examine how obstructive sleep apnea may contribute to …

progression of alzheimer's disease
obstructive sleep apnea
alzheimer's disease
continuous positive airway pressure
memory impairment
  • 0 views
  • 06 May, 2022
  • 1 location
First Line Obstructive Sleep Apnea Treatment Study (FLOSAT)

The main objective is to evaluate the overall effectiveness of MAD therapy as a first line treatment, including both efficacy in terms of reduction in OSA severity as well as objective compliance, in patients recently diagnosed with moderate to severe OSA, waiting for a new CPAP device. Upon completion of …

  • 0 views
  • 08 Jun, 2022
  • 1 location
Impact of Estrogen + Estradiol Receptor Alpha Modulator Therapy on Oxidative Stress in Post-menopausal Women With and Without Sleep Apnea (Alpha MenoX)

One of the most likely mechanisms explaining the sleep apnea (SA)-induced increase in metabolic syndrome is the oxidative stress (OS) induced by intermittent hypoxia (IH). There are clear-cut signs of OS in postmenopausal women that may be further enhanced by SA. In rats exposed to IH, an estradiol receptor alpha …

insomnia
hypoxia
  • 18 views
  • 20 Apr, 2022
  • 1 location
Simultaneous Operations on the Thyroid Gland and Hyoid Suspension in Patients With Combined Thyroid Pathology and OSA

Simultaneous operations on the thyroid gland and hyoid suspension in patients with combined thyroid pathology and moderate to severe OSA.

  • 0 views
  • 28 Oct, 2021
  • 1 location