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Found 5 clinical trials
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T Lymphocytes (LT) Expressing iCASP9 and CD19 in Allogeneic Haematopoietic Transplantation.

This study evaluates the frequency of occurrence, severity, and response to treatment by a chemical agent, notably the dimerizer AP1903 (Bellicum Pharmaceuticals compagny), in the case of acute

acute graft versus host disease
chronic myeloid leukemia
lymphoma
bone marrow transplant
graft versus host disease
  • 0 views
  • 04 Feb, 2021
  • 1 location
None
Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma

neurotoxicity as a result of being given iC9-CAR19 cells, the subject can be given a dose of a second study drug, AP1903, if standard interventions fail to alleviate the symptoms of cytokine release syndrome

cyclophosphamide
high grade b-cell lymphoma
lymphoma
graft versus host disease
cancer
  • 0 views
  • 08 Jul, 2021
  • 1 location
None
Umbilical & Cord Blood (CB) Derived CAR-Engineered NK Cells for B Lymphoid Malignancies

changed NK cells and the drug AP1903 (if you receive it, explained below) are not FDA approved or commercially available for use in this type of disease. They are currently being used for research

oximetry
lymphoma
cyclophosphamide
cancer
leukemia
  • 104 views
  • 28 Jul, 2021
  • 1 location
None
Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors

) in patients with GPC3-positive solid tumors such as yours. T cells made to carry a gene called iCasp9 can be killed when they encounter a specific drug called AP1903. The investigators will

experimental drug
cytoxan
neutrophil count
cancer
carcinoma
  • 0 views
  • 29 Jul, 2021
  • 1 location
None
GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)

The primary purpose of this study is to test whether GD2-CAR T cells can be successfully made from immune cells collected from children and young adults with H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) or spinal H3K27M-mutant diffuse midline glioma (DMG). H3K27Mmutant testing will occur as part of standard of care …

  • 0 views
  • 22 Aug, 2021
  • 1 location