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Found 159 clinical trials
Multi-center, Open-label, Phase 1b Clinical Trial to Evaluate the Safety, Tolerability, and Exploratory Efficacy of TEW-7197 in Combination With FOLFOX in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Who Have Failed First-Line Gemcitabine and Nab-Paclitaxel (MP-PDAC-01)

reference limit) at Screening (based on the normal range of relevant study center) Subjects who have risk factors for ascending aortic aneurysm such as genetic disorder and trauma and risk

metastatic pancreatic ductal adenocarcinoma
biliary stents
  • 29 Jun, 2022
  • 1 location
Effect of Progesterone on Testosterone Concentrations and Breast Development in Transwomen

Purpose. The purpose of this research is study the effect of progesterone therapy on testosterone levels in transwomen who are currently on gender affirming treatment with estradiol. Duration. It is expected that participation will last for 6 months (24 weeks). Study Procedures. Participants will be asked to sign an informed …

  • 04 Oct, 2022
  • 1 location
Evaluation of Aortic Stiffness as a Prognostic Indicator of Aortic Dilatation in Patients With Bicuspid Aortic Valve by Multimodal Imaging (IRM-BAO)

The objective is the development and validation of morphological markers informative of aortic dilatation in order to improve the precision of the risk of aneurysm of the thoracic aorta and of acute aortic syndrome for patients with bicuspid aortic valve (BAV). The primary objective of this study is to demonstrate …

  • 07 Apr, 2022
  • 1 location
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and did not reveal any studies on this issue. In 2019 at …

  • 04 Oct, 2022
  • 1 location
ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair. (ACTION-1)

Aim of the ACTION-1 study is to determine whether ACT guided heparinization decreases thrombo-embolic complications (TEC) and mortality after elective open AAA surgery, without causing more

aneurysm repair
open repair
aaa surgery
aortic aneurysm
  • 02 Mar, 2022
  • 18 locations
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance (TITAN:SvS)

ascending aortic surgery to those patients undergoing surveillance. Patients referred for an ascending aortic aneurysm that meets the inclusion criteria will be randomized to the early elective surgery

  • 13 May, 2022
  • 18 locations
Endurant Stent Graft System vs Excluder Endoprothesis: A Global, Prospective, Randomized Clinical Trial in Sac Regression (ADVANCE)

Endoprosthesis in subjects with Abdominal Aortic Aneurysms. Subjects will be randomized and imaging will be collected at all follow-up time points to assess the primary endpoint.

  • 15 Sep, 2022
  • 3 locations
Randomized Preventive Vascular Screening Trial of 65-74 Year Old Men in the Central Region of Denmark

extremely relevant to offer joint screening for abdominal aortic aneurysm, peripheral arterial disease and hypertension, even if the benefit and costs of such a measure are not currently known.

vascular surgery
vascular surgical procedures
  • 23 Jan, 2022
  • 1 location
Implementing Tobacco Use Treatment in HIV Clinics Vietnam (Vquit)

outpatient clinics (OPCs): 1)3As+Referral to the national quitline: Ask about tobacco use, Advise to quit, Assist with brief counseling and Refer to Viet Nam's national Quitline; 2) AAA+ +Counsel (Counsel=6

nicotine product
nicotine replacement
  • 13 May, 2022
  • 1 location
Danish Cardiovascular Screening Trial II (DANCAVAS-II)

This study attempts to reduce social inequality in cardiovascular health by performing an interventional screening trial on how best to decrease cardiovascular disease (CVD) among people with low social status.

cardiovascular disease
  • 06 Feb, 2022
  • 4 locations