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Found 43 clinical trials
Quantification of Debris Captured Using TCEP During VIV TAVR With BVF

The objective of this study is to quantify the amount of debris captured by the SENTINEL transcatheter cerebral embolic protection (TCEP) device in patients undergoing valve in valve transcatheter aortic valve replacement (VIV TAVR) with bioprosthetic valvular fracture (BVF)

  • 0 views
  • 18 Apr, 2022
  • 1 location
  • 0 views
  • 05 Jul, 2021
  • 1 location
TriRec - Trileaflet Reconstruction of the Aortic Valve With Autologous Pericardium (TriRec)

Reconstruction of the aortic valve using the tri-leaflet repair technique is non-inferior with regard to effective orifice area (EOA) to surgical aortic valve replacement (SAVR) with a biological prosthesis (St. Jude Trifecta GT) as gold- standard.

  • 0 views
  • 05 Mar, 2022
  • 1 location
Combined Transcatheter Aortic Valve Implantation and Percutaneous Closure of the Left Atrial Appendage (TAVI-LAAC)

Atrial fibrillation (AF) is a common comorbidity of patients candidates to transcatheter aortic valve implantation (TAVI). The management of chronic oral anticoagulation (OAC) for the prevention of ischemic stroke is very challenging in this population of complex and frail subjects. Since the percutaneous left atrial appendage (LAA) closure with the …

Accepts healthy volunteers
stroke
atrial fibrillation
transcatheter aortic valve implant
aortic valve stenosis
  • 0 views
  • 22 Mar, 2022
  • 4 locations
Long-term Anticoagulation With Oral Factor Xa Inhibitor Versus Vitamin K Antagonist After Mechanical Aortic Valve Replacement (RENOVATE)

This study evaluates the long-term anticoagulation with oral factor Xa inhibitor versus vitamin K antagonist in patients receiving a mechanical aortic valve replacement.

rivaroxaban
factor xa inhibitor
warfarin
regurgitation
  • 0 views
  • 10 Mar, 2022
  • 1 location
PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

Currently, warfarin is the only approved anticoagulation for patients with mechanical valves. The purpose of this study is to determine if participants with an On-X Prosthetic Heart Valve / On-X aortic valve can be maintained safely and effectively on apixaban. Both the On-X aortic valve and apixaban have been approved …

aspirin
warfarin
apixaban 5 mg
  • 117 views
  • 27 Jun, 2022
  • 61 locations
GLP-1 and Hyperoxia for Organ Protection in Heart Surgery (GLORIOUS)

Patients undergoing open heart surgery are at risk of suffering damage to the heart, brain and kidneys. This study is designed as a 2-by-2 randomized clinical trial with the purpose of investigating the organ protective effects of the glucagon-like-peptide-1 (GLP-1) agonist Exenatide versus placebo and restrictive versus liberal oxygenation during …

aortic valve replacement
ischemic heart disease
heart disease
bypass graft
percutaneous coronary intervention
  • 40 views
  • 27 Jan, 2022
  • 1 location
Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation (POPular PAUSE TAVI)

Transcatheter aortic valve implantation (TAVI) is a rapidly growing treatment option for patients with aortic valve stenosis. Stroke is a feared complication of TAVI, with an incidence of around 4-5% in the first 30 days. Up to 50% of patients undergoing TAVI have an indication for oral anticoagulants (OAC) mostly …

anticoagulants
myocardial infarction
infarct
stroke
aortic valve stenosis
  • 8 views
  • 24 Mar, 2022
  • 1 location
Effect of PCSK9 InhibitorS On Calcific Aortic Valve DiseasE

Calcific Aortic Stenosis (CAS) can cause severe adverse cardiac events, but there is currently no effective drug that can prevent or delay the progression of the disease, aortic valve replacement is still the only therapy. The epidemiology of CAS shows that it is related with level of Lp(a)LDL-C and PCSK9. …

aortic valve stenosis
stenosis
  • 0 views
  • 17 Sep, 2021
  • 1 location
Ambulatory Electrocardiographic Monitoring for the Detection of High-Degree Atrio-Ventricular Block in Patients With New-onset PeRsistent LEft Bundle Branch Block After Transcatheter Aortic Valve Implantation. The "MARE" Study

The purpose of this study is to determine the incidence and predictors of high degree or complete atrioventricular block (AVB) (paroxysmal or persistent) in patients with new-onset persistent left bundle branch block (NOP-LBBB) following transcatheter aortic valve implantation (TAVI) and to evaluate the usefulness of the Reveal LINQ insertable Cardiac …

transcatheter aortic valve implant
left bundle branch block
  • 0 views
  • 27 Sep, 2021
  • 1 location