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Found 10 clinical trials
Prospective, Single-arm Pivotal Study for the Treatment of Subjects With Severe Symptomatic Calcific Aortic Valve Stenosis Using Valvosoft® Non-Invasive Ultrasound Therapy (NIUT)

The objective of the study is to evaluate the safety and performance of a new non-invasive ultrasound therapy (NIUT) with Valvosoft in the treatment of Calified Aortic Stenosis

aortic valve stenosis
stenosis
  • 0 views
  • 11 Oct, 2022
  • 5 locations
Blood Pressure Reduction in Patients With Asymptomatic Aortic VALVE Stenosis

to conventional treatment. Strict BP control for 2 years reduces the increase in aortic valve calcification and LV remodelling compared to conventional treatment. Strict BP

aortic valve replacement
aortic valve stenosis
stenosis
antihypertensive drugs
  • 0 views
  • 26 Jan, 2021
  • 6 locations
SLOW-Slower Progress of caLcificatiOn With Vitamin K2

A randomized 12-month trial will include two groups of 100 individuals aged over 50 years, with asymptomatic mild to moderate Aortic valve stenosis (AVA > 1 cm2, Vmax < 4 m/s). The first group of 100 individuals will serve as the intervention group that will receive 300 mcg of K2 …

vitamin k
aortic valve stenosis
stenosis
  • 4 views
  • 08 Sep, 2021
  • 2 locations
Colchicine and Inflammation in Aortic Stenosis (CHIANTI)

Aortic stenosis (AS) is the most common valvular heart disease in the developed world. Once symptomatic, untreated patients have a poor prognosis with five-year survival rate of 25%. Once at an advanced stage, AS will lead to the development of left ventricle hypertrophy, and eventually heart failure and death. At-present, …

heart failure
atherosclerosis
stenosis
heart disease
  • 0 views
  • 10 Jul, 2022
  • 1 location
Effect of PCSK9 InhibitorS On Calcific Aortic Valve DiseasE

and 96 weeks for a minimum of 2 years. The primary endpoint is the average annual change in aortic-jet velocity. Secondary endpoints include average annual change of aortic valve calcification score

aortic valve stenosis
stenosis
  • 0 views
  • 17 Sep, 2021
  • 1 location
Anatomic Stenosis Severity as a Prognostic Marker in Patients With Low-Flow Low-Gradient Aortic Stenosis Undergoing TAVI

paradoxical low-flow, low-gradient aortic stenosis (LFLG AS) with available non-contrast MSCT data on aortic valve calcification (AVC). The main objective of this study is the assessment of outcome after TAVI

  • 0 views
  • 11 Jun, 2021
  • 11 locations
Identification of Genetic Causes of Calcific Aortic Valve Disease

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

aortic disease
aortic valve replacement
aortic valve disease
Accepts healthy volunteers
aortic surgery
  • 0 views
  • 04 Oct, 2022
High-Sensitivity Troponin T Plasma Levels in Patients With Aortic Stenosis (Tyrolean Aortic Stenosis Study-2)

TASS-2 (Tyrolean Aortic Stenosis Study-2) aims to characterize the clinical value of minimally elevated troponin T plasma levels both in patients with asymptomatic and symtomatic aortic stenosis.

troponin
stenosis
  • 120 views
  • 31 Oct, 2021
  • 1 location
Development of a Serum and Cellular Biomarkers Cluster for the Assessment of Degenerative Aortic Valve Stenosis Progression. (AthenaValve)

AthenaValve aims to develop and initial validate a novel serum diagnostic kit, for the assessment of severity and prognosis of progression of aortic valve stenosis (AS, a devastating disease without early diagnosis and medical treatment). Two independent clinical cohorts of patients will provide serum samples, along with tissue and serum …

ct scan
calcium
aortic valve stenosis
stenosis
  • 0 views
  • 22 Oct, 2022
  • 2 locations
Metabolic Determinants of the Progression of Aortic Stenosis

identify the metabolic factors that determine the progression of: i) aortic valve calcification and stenosis; ii) myocardial fibrosis and dysfunction; and iii) clinical outcomes. This study will

MRI
coronary artery disease
medical therapy
aortic valve calcification
ct scan
  • 0 views
  • 27 Sep, 2021
  • 1 location