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Found 120 clinical trials
Featured trial
Heart Valve Disease – Aortic and Mitral

Study Description: Multi-center, international, prospective, randomized, interventional, pre-market study. Patients will be seen at pre and post-procedure, discharge, 30 days, 6 months, 1 year, 18 months, and annually through 10 years. Randomly assigned (50% to either group) Treatment of Aortic Stenosis with either Transcatheter Aortic Valve Replacement (TAVR) device or …

aortic valve replacement
  • 05 Feb, 2021
  • 1 location
Comparing Hypothermic Temperatures During Hemiarch Surgery (TITAN:COMMENCE)

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend …

  • 10 May, 2022
  • 4 locations
Efficacy of Clopidogrel on Incidence of Silent Brain Infarction (ECISBI)

Silent brain infarctions (SBIs) are a manifestation of covert cerebrovascular disease, without obvious clinical deficit, noted very often in patients presenting with a new stroke or new transient ischemic attack. SBIs are linked to a significant increase in risk for subsequent stroke and cognitive decline. However, no biomarker is currently …

  • 22 Apr, 2022
  • 1 location
Personalized Activity Intervention in Rehabilitation After Cardiac Operations (the PACO Trial) (PACO)

The PACO trial is a randomized clinical trial conducted in Heart Centers of Kuopio and Turku university hospitals. The coronary artery disease, aortic valve stenosis and mitral valve

rehabilitation program
aortic valve replacement
arterial disease
coronary artery bypass graft
heart surgery
  • 02 Mar, 2022
  • 1 location
Endovascular Repair of Descending ThoracoAbdominal Aortic Pathologies Using Physician Modified Endovascular Prosthesis

This is an early feasibility study that investigates the outcome of selected patients with complex thoracoabdominal aortic lesions who are suitable for endovascular (within the vessel) repair with a physician-modified Medtronic Thoracic Valiant stent graft. The Medtronic Valiant System includes a Valiant Thoracic Stent Graft, a self-expanding, tubular end prosthesis …

  • 26 Jan, 2021
  • 2 locations
Effects of MICT on Cardiopulmonary Function in Patients After TAVI

Cardiac rehabilitation (CR), particularly regular exercise, can improve the cardiopulmonary function, exercise capacity, and quality of life for patients undergoing transcatheter aortic valve implantation (TAVI). Consequently, the patients after TAVI will be enrolled in our randomized controlled trial to demonstrate if the moderate-intensity continuous training (MICT) can improve the cardiopulmonary …

  • 25 Jul, 2022
  • 1 location
Feasibility of Endovascular Repair Of Ascending Aortic Pathologies

The purpose of this study is to investigate the outcome of patients with pathologies of the ascending thoracic aorta (diseases in the great blood vessel or artery that leads away from the heart

type b aortic dissection
  • 08 Aug, 2022
  • 2 locations
Effect of PCSK9 InhibitorS On Calcific Aortic Valve DiseasE

Calcific Aortic Stenosis (CAS) can cause severe adverse cardiac events, but there is currently no effective drug that can prevent or delay the progression of the disease, aortic valve

aortic valve stenosis
  • 17 Sep, 2021
  • 1 location
B-SAFER: Branched Stented Anastomosis Frozen Elephant Trunk Repair (B-SAFER)

A prospective, single-center, non-blind, non-randomized safety and feasibility study of the hybrid repair of thoracic aortic pathologies requiring repair of the aortic arch proximal to the origin of innominate artery.

aortic aneurysm
  • 01 May, 2022
  • 1 location
Trial to Investigate the Benefit of Elective Para-Aortic Radiotherapy (PART) for pN1 Prostate Cancer (PART)

Prospective non-randomized phase 2 trial to study the efficacy of additional elective para-aortic RT (PART) in pN1 patients compared to those who were historically treated with adjuvant whole pelvic radiotherapy (WPRT) alone.

immunological adjuvant
  • 25 Feb, 2022
  • 1 location