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Found 59 clinical trials
Study of the Efficacy and Safety of HS-10234 in Patients With Chronic Hepatitis B Virus Infection

The primary objective of this study is to compare the safety and efficacy of HS-10234 versus tenofovir disoproxil fumarate (TDF) in treatment-naive and treatment-experienced adults with chronic hepatitis B virus (HBV) infection.

  • 22 Jan, 2021
  • 1 location
Safety and Immunotherapeutic Activity of Cemiplimab in Participants With HBV on Suppressive Antiviral Therapy

The purpose of this study is to evaluate the safety and immunotherapeutic activity of cemiplimab in participants with hepatitis B virus (HBV) on suppressive antiviral therapy.

  • 27 Apr, 2021
  • 7 locations
Changes in Liver Fibrosis Lipid Profile and Insulin Resistance in HCV Patients Who Received Antiviral Therapy

Hepatitis C virus (HCV) is one of the major globally cause of death and morbidity.Chronic hepatitis C is the leading cause of end-stage liver disease, hepatocellular carcinoma and liver-related death in Egypt.It could be considered a special type of metabolic diseases involving insulin resistance (IR) which accelerates fibrosis and modulation …

antiviral drugs
liver disease
hepatocellular carcinoma
antiviral therapy
hepatic fibrosis
  • 25 Jan, 2021
  • 1 location
Systemic and Topical Antivirals for Control of Cytomegalovirus Anterior Uveitis: Treatment Outcomes

directed polymerase chain reaction (PCR) testing. While antiviral therapy exists for CMV, identifying the appropriate therapy has been challenging because no randomized trials comparing routes of therapy

  • 08 May, 2021
  • 1 location
Study of 2LHERP in Genital Herpes Infections

appear at any age. No specific antiviral therapy is available to totally cure herpetic infections and today, there is no treatment that allows the definitive eradication of the virus. The 2LHERP

  • 22 Feb, 2021
  • 11 locations
Efficacy and Safety of TAF in Patients With Suboptimal Response to Other Nucleos(t)Ides

antiviral therapy with nucleos(t)ide treatment is associated with an increased risk of subsequent treatment failure and viral resistance. It remains unclear whether switching to TAF is a reasonable approach

antiviral drugs
liver disease
antiviral therapy
  • 26 Jan, 2021
  • 10 locations
Nucleoside (Acid) Analogues Treatment in Patients With Normal ALT and Positive HBVDNA.

This study is to investigate the clinical efficacy and safety of Nucleoside (acid) analogues treatment in patients with normal Alanine Aminotransferase and positive Hepatitis B virus DNA.

  • 30 Apr, 2021
  • 1 location
Evaluating Adjunctive Cryopreserved Amniotic Membrane Treatment in Herpes Simplex Dendritic Keratitis

To prospectively evaluate the effectiveness of Prokera Slim in adults with primary or recurrent herpetic epithelial keratitis in terms of visual function, corneal opacity, time to resolution, cost of care, number of patient visits.

  • 19 Mar, 2021
  • 1 location
Levels of Interleukin-6 andTransforming Growth Factor Beta in HCV Patients Sera

Hepatitis C virus (HCV) infection is associated with significant morbidity and mortality owing to progression of a high percentage (85%) of HCV infected patients to chronic hepatitis, which might lead to the development of liver cirrhosis or hepato cellular carcinoma.. Egypt has possibly the highest HCV prevalence in the world, …

  • 24 Mar, 2021
  • 1 location
Study on the Use of Sarilumab in Patients With COVID-19 Infection

Sarilumab is an anti-interleukin-6 human monoclonal antibody, such as tocilizumab, which is administered subcutaneously every two weeks for the treatment of moderate to severe active rheumatoid arthritis in adult patients. Despite the effectiveness reported for tocilizumab in the recently published experiences, the need to rapidly find alternative therapies to manage …

  • 26 Jul, 2021
  • 1 location