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Found 209 clinical trials
MGD014 in HIV-Infected Individuals on Suppressive Antiretroviral Therapy

This is a Phase 1, open-label single-center study to determine the safety of MGD014 in participants with human immunodeficiency virus (HIV) infection on stable suppressive antiretroviral therapy

  • 28 views
  • 19 Feb, 2021
  • 1 location
Adjusting Antiretroviral Therapy Dosage Using Therapeutic Drug Monitoring

Background Low concentrations of protease inhibitors (PIs) or nonnucleoside reverse transcriptase inhibitors (NNRTIs) are associated with an increased risk of virological failure. Likewise, excessive antiretroviral drug concentrations increase the risk of toxicity. Therapeutic drug monitoring (TDM) may identify and correct excessively high or low PI and/or NNRTI concentrations, and thus …

antiretroviral therapy
efavirenz
reverse transcriptase inhibitor
antiretroviral agents
lopinavir
  • 7 views
  • 07 Nov, 2020
  • 1 location
Rapid Start vs. Standard Start Antiretroviral Therapy (ART) in HIV

This study plans to learn about whether starting HIV treatment very soon after diagnosis is more beneficial than waiting until entering routine clinical care after diagnosis.

  • 0 views
  • 28 Jan, 2021
  • 3 locations
Dihydroartemisinin-Piperaquine in the Context of Antiretroviral Therapy

)-based antiretroviral therapy (ART) and HIV-uninfected children not on ART. All children will be malaria-uninfected at the time of enrollment.

  • 0 views
  • 27 Jan, 2021
  • 2 locations
Same-day Antiretroviral Therapy With BIC/F/TAF

confirmatory tests, with the use of the newly developed point-of-care immunochromatographic confirmatory test, initiating a safe and potent antiretroviral therapy, BIC/F/TAF, on the same day of HIV

  • 0 views
  • 29 Jan, 2021
  • 1 location
Cannabis Effects on Antiretroviral Therapy Pharmacokinetics and Neurotoxicity

This study will address whether cannabis affects antiretroviral therapy (ART) drug concentrations, mood, and thinking. The project will have two phases. Phase 1 is an observational study, in

  • 0 views
  • 23 Mar, 2021
  • 1 location
HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Background Some people with Amyotrophic Lateral Sclerosis (ALS) have a high level of the virus HERV-K in their blood. Researchers do not think this virus causes ALS. But they don t know why some people with ALS have a high level of it. They want to know if HERV-K can …

primary lateral sclerosis
edaravone
riluzole
  • 82 views
  • 04 Aug, 2021
  • 1 location
Reducing the Residual Reservoir of HIV-1 Infected Cells in Patients Receiving Antiretroviral Therapy

This study is a prospective, open-label, randomized, three-arm, dose-escalation exploratory pilot clinical trial involving HIV-1 infected participants treated with suppressive combination antiretroviral combination therapy (cART). The study will test whether combined treatment with the histone deacetylase inhibitor panobinostat and the immunomodulatory cytokine Interferon-alpha2a can reduce the residual reservoir of HIV-1 …

coronary heart diseases
antiretroviral therapy
HIV Vaccine
hepatitis
antiretroviral
  • 0 views
  • 05 Mar, 2021
  • 1 location
Oral Dydrogesterone vs. Vaginal Micronized Progesterone for Luteal Phase Support in Frozen-thawed Embryo Transfer

The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.

  • 3 views
  • 26 Jan, 2021
  • 1 location
A Sibling Oocyte Study- Comparison of ZyMotTM Microfluidics Device to Density Gradient for Sperm Selection During ICSI

The primary objective of this study is to evaluate whether the percentage of good quality embryo formation following Intracytoplasmic Sperm Injection (ICSI) is improved with the use of ZyMot method of microfluidic sperm separation compared to density gradient.

  • 0 views
  • 05 Aug, 2021