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Found 215 clinical trials
TB Screening Improves Preventive Therapy Uptake

HIV-infected people have an increased risk of developing active tuberculosis (TB). To reduce the burden of TB among people living with HIV (PLHIV), the World Health Organization (WHO) recommends systematic TB screening followed by 1) confirmatory TB testing for all those who screen positive and 2) TB preventive therapy (TPT) …

  • 0 views
  • 27 Jan, 2021
  • 1 location
ADAPT for Adolescents Adolescents

Adolescents and young adults (AYA) with HIV face unique challenges to engagement in care and their ability to achieve optimal health outcomes. The investigators hypothesize that developmentally-tailored behavioral interventions will improve engagement in HIV care and viral suppression among AYA with HIV in Kenya. This two stage study will initially …

  • 0 views
  • 29 Jun, 2021
  • 1 location
Partners-based HIV Treatment for Couples Attending Antenatal Care

The purpose of this R01 proposal is to evaluate the clinical impact, hypothesized mechanisms of behavior change, and cost-effectiveness of a partners-focused integrated elimination of mother-to-child transmission of HIV (EMTCT) package comprised of: 1) antenatal care-based couples HIV testing, ART enrollment, and care for sero-concordant HIV+ expectant couples; (2) Couples-based …

AIDS
mother-to-child transmission
HIV Infection
prenatal care
HIV Vaccine
  • 0 views
  • 19 Mar, 2021
  • 1 location
B-Enhancement of HBV Vaccination in Persons Living With HIV (BEe-HIVe): Evaluation of HEPLISAV-B

The purpose of this study is to evaluate response to and safety of the HBV vaccine HEPLISAV-B in two study populations living with HIV: prior HBV vaccine recipients who are deemed non-responders and individuals who are nave to HBV vaccination.

HIV Vaccine
engerix-b
vaccination
  • 0 views
  • 22 Jul, 2021
  • 34 locations
The Late Presenter Treatment Optimisation Study

The main purpose of this study is to compare two different types of HIV treatments, in terms of effectiveness and improvement of side effects, for patients who are diagnosed with a more advanced HIV infection. Patients with advanced HIV infections are otherwise known as 'late presenters'. There are many effective …

protease
emtricitabine
darunavir
HIV Infection
tenofovir
  • 120 views
  • 28 Mar, 2021
  • 36 locations
Testing Strategies for Couple Engagement in PMTCT and Family Health in Kenya

This study will test the efficacy and cost-effectiveness of an interdependence theory-based couples intervention in Kenya that reaches pregnant women and male partners through home visits by male-female pairs of lay health workers, and includes offer of home-based CHTC services.

HIV Vaccine
PMTCT
hiv test
  • 41 views
  • 14 Jun, 2021
  • 1 location
Supporting Treatment Outcomes Among PWID

The goal of this study is to improve HCV care continuum outcomes for people who inject drugs (PWID), reduce potential onward transmission to others and improve HIV outcomes among those who are HIV/HCV coinfected. The study will evaluate whether HCV treatment outcomes (sustained virologic response, treatment completion, adherence) and post …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Drinkers' Intervention to Prevent Tuberculosis (DIPT Study)

There is an urgent global need to decrease the high mortality of tuberculosis (TB) in persons with HIV as TB is the leading cause of death among persons with HIV worldwide. The DIPT (Drinkers' Intervention to Prevent TB) study is a randomized, 2x2 factorial trial among HIV/TB co-infected adults in …

antiretroviral therapy
tuberculin test
isoniazid
heavy drinking
antiretroviral agents
  • 15 views
  • 11 Jul, 2021
  • 2 locations
Viral Load Triggered ART Care in Lesotho

This cluster randomized clinical trial at 18 nurse-led rural health centers in Lesotho will test an automated differentiated service delivery model using viral load results, other clinical characteristics and participants' preference to automatically triage participants into groups requiring different levels of attention and care.

tuberculosis
antiretroviral therapy
antiretroviral agents
  • 0 views
  • 07 Jun, 2021
  • 14 locations
IMPACt of an Enhanced Screening Program on the Detection of Non-AIDS NEOplasms in HIV Patients

Introduction: The incidence of malignancies is higher in the HIV-infected population than in the general population, and it is already one of the leading causes of death in people living with the virus. It is estimated that the situation will be aggravated by the progressive aging of the HIV-infected population. …

  • 0 views
  • 15 Feb, 2021
  • 1 location