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Found 267 clinical trials
Testing Strategies for Couple Engagement in PMTCT and Family Health in Kenya (Jamii Bora)

This study will test the efficacy and cost-effectiveness of an interdependence theory-based couples intervention in Kenya that reaches pregnant women and male partners through home visits by male-female pairs of lay health workers, and includes offer of home-based CHTC services.

HIV Vaccine
Accepts healthy volunteers
PMTCT
hiv test
  • 41 views
  • 03 Mar, 2022
  • 1 location
Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis (NEW-STRAT TB)

The New Strat-TB trial is a superiority Phase III randomised control clinical trial with a 2X2 factorial design. The main aim of the study is to assess the efficacy and safety of high dose rifampicin and levofloxacin for 14 days in addition to standard TB therapy with or without steroids …

  • 0 views
  • 23 Apr, 2022
Addressing the Continuum of Care Among High-risk Thai Men

Young Thai men who have sex with men (YMSM) are at high risk for HIV. However, the Thailand National HIV Strategy does not adequately cover HIV prevention for YMSM using specific methods relevant to them, and instead uses a one-size-fits all approach. Partnering with the Thailand Ministry of Public Health …

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 2 locations
Increasing Engagement and Improving HIV Outcomes Via HealthMPowerment

The overall goal of this 3-arm randomized trial is to test whether a network-driven online intervention tailored for intersectional stigma amelioration can elicit online social support, promote intervention engagement, and mitigate the impact of multiple stigmas on HIV-related outcomes among young Black and/or Latino men who have sex with men …

HIV Vaccine
Accepts healthy volunteers
hiv test
  • 69 views
  • 25 Mar, 2022
  • 3 locations
The Late Presenter Treatment Optimisation Study (LAPTOP)

The main purpose of this study is to compare two different types of HIV treatments, in terms of effectiveness and improvement of side effects, for patients who are diagnosed with a more advanced HIV infection. Patients with advanced HIV infections are otherwise known as 'late presenters'. There are many effective …

tenofovir
integrase inhibitors
oophorectomy
HIV Infection
darunavir
  • 124 views
  • 16 May, 2022
  • 43 locations
Supporting Treatment Outcomes Among PWID (STOP-C)

The goal of this study is to improve HCV care continuum outcomes for people who inject drugs (PWID), reduce potential onward transmission to others and improve HIV outcomes among those who are HIV/HCV coinfected. The study will evaluate whether HCV treatment outcomes (sustained virologic response, treatment completion, adherence) and post …

atazanavir
HIV Vaccine
  • 0 views
  • 23 May, 2022
  • 1 location
More Options for Children and Adolescents (MOCHA): Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in HIV-Infected Children and Adolescents (MOCHA)

The purpose of this study is to determine the dosage for oral and IM Cabotegravir LA and IM Rilpiverine LA and evaluate the safety, acceptability, tolerability, and pharmacokinetics of oral and long-acting injectable cabotegravir and long-acting injectable rilpivirine in virologically suppressed HIV-infected children and adolescents.

HIV Vaccine
hiv-1 rna measurement
body mass index
antiretroviral
antiretroviral agents
  • 3 views
  • 16 Jun, 2022
  • 21 locations
A Comprehensive HIV Prevention Package for South African Adolescent Girls and Young Women

To achieve an AIDS-free generation, there is a critical need for programs which go beyond individual-level behavior change to reduce HIV and STI infections among adolescent girls and young women in sub-Saharan Africa. Informed, Motivated, Aware, and Responsible Adolescents and Adults (IMARA) is an evidence-based HIV-prevention intervention for adolescent girls …

HIV Vaccine
Accepts healthy volunteers
AIDS
pre-exposure prophylaxis (prep)
hiv test
  • 0 views
  • 23 Nov, 2021
  • 1 location
Isisekelo Sempilo Trial to Optimize Peer (Thetha Nami) Delivery of HIV Prevention to Young People in Rural KwaZulu-Natal

Despite advances in efficacious, efficient and safe biomedical tools to reduce HIV transmission and acquisition the HIV epidemic in South Africa(SA) remains an intractable problem, with the lifetime risk of infection approaching 70% for a 15-year-old girl currently living in northern KwaZulu-Natal, the Africa Health Research Institute(AHRI) research setting. This …

Accepts healthy volunteers
  • 0 views
  • 10 Mar, 2022
  • 1 location
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations (ACTION)

This is a 5-year Hybrid Type 1 Effectiveness-Implementation Randomized Control Trial (RCT) that compares two models of linking and retaining individuals recently released from custody to the continuum of community-based HIV and opioid use disorder (OUD) prevention and treatment, medication for opioid use disorder (MOUD) service cascades of care.

opioid
stimulant
opioid use
injection drug
  • 0 views
  • 27 Apr, 2022
  • 2 locations