Found 159 clinical trials
Intervention to Improve HIV Care Retention by Addressing Stigma Stigmatized Environments
Retention in care and persistent adherence to antiretroviral therapy are necessary for the successful treatment of HIV infection. HIV-related stigma is a known impediment to the care and health
- 0 views
- 16 Nov, 2021
- 2 locations
An Enhanced Package of Care to Reduce Reduce Mortality in Advanced HIV Disease (ENCORE)
A community-based Phase III, cluster randomized trial that seeks to determine the 24 week survival with retention in care of point of care CD4 testing with visitect and an enhanced package of screening and prophylaxis for opportunistic infections among patients with advanced HIV disease.
- 0 views
- 04 Oct, 2022
- 1 location
Combination Antiretroviral Therapy (cART) for PBC
Placebo Controlled, double-blind randomized controlled trial (RCT) with 12 months Tenofovir Disoproxil and Raltegravir for primary biliary cholangitis (PBC) patients unresponsive to Ursodeoxycholic Acid (UDCA). Placebo patients will be offered 12 months open label therapy at unblinding. All patients will be offered an additional 12 months open label therapy. Observational, …
- 16 views
- 25 Apr, 2022
- 1 location
Pilot Study to Investigate the Safety and Feasibility of AntiRetroviral Therapy for Alzheimer's Disease (ART-AD)
The objective of the study is to evaluate the ability of (-)-L-2',3'-dideoxy-3'-thiacytidine (3TC) to engage its intended target, penetrate the central nervous system (CNS), suppress neurodegeneration, and assess safety and tolerability in patients with early stage Alzheimer's disease. This study will provide the initial data on target engagement and Alzheimer's …
- 1 views
- 27 Apr, 2022
- 3 locations
Switching From TDF-based Antiretroviral Therapy Regimens to B/F/TAF in Virally Suppressed Adults With HIV-1 Infection
To evaluate the safety and efficacy of bictegravir/emtricitabine/tenofovir alafenamide versus tenofovir disoproxil fumarate-based antiretroviral regimens in HIV-infected individuals with virological suppression.
- 0 views
- 12 Mar, 2022
- 2 locations
Study of VRC07-523LS, CAP256V2LS, and Vesatolimod, in Early Antiretroviral-treated HIV-1 Clade C-infected Women
sequential regimen with a toll-like receptor (TLR)7 agonist, vesatolimod (VES), when administered in virologically suppressed HIV-1 Clade C-infected women on antiretroviral therapy (ART) and during
- 0 views
- 04 Oct, 2022
- 1 location
Positive Steps to Enhance Problem Solving Skills (STEPS)
This randomized control trial is to test the efficacy of a stepped-care "adaptive" Antiretroviral Therapy (ART) adherence intervention ("Positive STEPS") for HIV infected adolescents and young
- 5 views
- 24 May, 2022
- 3 locations
Allogeneic Adoptive Immune Therapy for Advanced AIDS Patients
Combined antiretroviral therapy (ART) efficiently suppresses viral replication and markedly decreases mortality among patients with HIV-1 infection/AIDS. While the advanced AIDS patients with
- 0 views
- 16 Feb, 2022
- 1 location
Imaging and Biopsy of HIV-Infected Individuals Undergoing Analytic Treatment Interruption
Background Human immunodeficiency virus (HIV) infects CD4 T cells. There is no cure for HIV. People with HIV need to take daily medications called antiretroviral
- 0 views
- 25 Oct, 2022
- 1 location
Unobtrusive Sensing of Medication Intake ("USE-MI") (USE-MI)
The purpose of this study is to test the USE-MI system hardware and software to see if it can accurately measure when subjects take their HIV-related medications and help them remember to take these medications. With the use of a smartwatch and smartphone "app", investigators hope to be able to …
- 0 views
- 16 May, 2022
- 1 location