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Found 192 clinical trials
Intervention to Improve HIV Care Retention by Addressing Stigma Stigmatized Environments

Retention in care and persistent adherence to antiretroviral therapy are necessary for the successful treatment of HIV infection. HIV-related stigma is a known impediment to the care and health

  • 0 views
  • 16 Nov, 2021
  • 2 locations
Behavioural Text Messages to Improve Retention in Care in South Africa

behavioural economics principles increase clinic attendance among recipients of care on antiretroviral therapy in South Africa. We hypothesize that messages incorporating behavioural economics principles will

  • 0 views
  • 19 Sep, 2021
  • 1 location
Combination Antiretroviral Therapy (cART) for PBC

Placebo Controlled, double-blind randomized controlled trial (RCT) with 12 months Tenofovir Disoproxil and Raltegravir for primary biliary cholangitis (PBC) patients unresponsive to Ursodeoxycholic Acid (UDCA). Placebo patients will be offered 12 months open label therapy at unblinding. All patients will be offered an additional 12 months open label therapy. Observational, …

  • 16 views
  • 25 Apr, 2022
  • 1 location
Pilot Study to Investigate the Safety and Feasibility of AntiRetroviral Therapy for Alzheimer's Disease (ART-AD)

The objective of the study is to evaluate the ability of (-)-L-2',3'-dideoxy-3'-thiacytidine (3TC) to engage its intended target, penetrate the central nervous system (CNS), suppress neurodegeneration, and assess safety and tolerability in patients with early stage Alzheimer's disease. This study will provide the initial data on target engagement and Alzheimer's …

mental state examination
dementia
mini-mental state examination
  • 0 views
  • 27 Apr, 2022
  • 3 locations
Switching From TDF-based Antiretroviral Therapy Regimens to B/F/TAF in Virally Suppressed Adults With HIV-1 Infection

To evaluate the safety and efficacy of bictegravir/emtricitabine/tenofovir alafenamide versus tenofovir disoproxil fumarate-based antiretroviral regimens in HIV-infected individuals with virological suppression.

  • 0 views
  • 12 Mar, 2022
  • 2 locations
Positive Steps to Enhance Problem Solving Skills (STEPS)

This randomized control trial is to test the efficacy of a stepped-care "adaptive" Antiretroviral Therapy (ART) adherence intervention ("Positive STEPS") for HIV infected adolescents and young

Accepts healthy volunteers
  • 5 views
  • 24 May, 2022
  • 3 locations
Allogeneic Adoptive Immune Therapy for Advanced AIDS Patients

Combined antiretroviral therapy (ART) efficiently suppresses viral replication and markedly decreases mortality among patients with HIV-1 infection/AIDS. While the advanced AIDS patients with

  • 0 views
  • 16 Feb, 2022
  • 1 location
Unobtrusive Sensing of Medication Intake ("USE-MI") (USE-MI)

The purpose of this study is to test the USE-MI system hardware and software to see if it can accurately measure when subjects take their HIV-related medications and help them remember to take these medications. With the use of a smartwatch and smartphone "app", investigators hope to be able to …

  • 0 views
  • 16 May, 2022
  • 1 location
Dolutegravir-Lamivudine for na ve HIV-Infected Patients With 200 CD4/mm3

Protocol Title: DOLCE: Dolutegravir-Lamivudine for nave HIV-Infected Patients with 200 CD4/mm3 Protocol Number: FH-57 Study Objectives: To assess the antiviral activity at week 48 of DTG+3TC among nave HIV patients with a CD4 count 200 cells /mm3.

  • 0 views
  • 04 Oct, 2021
  • 4 locations
Intermittent Oral Naltrexone Enhanced With an Ecological Momentary Intervention for Methamphetamine-using MSM

This is a double-blind, placebo-controlled phase 2b trial in which 54 MSM who use meth will be randomly assigned (2:1) to receive 12 weeks of as-needed intermittent oral naltrexone 50 mg enhanced with an EMA-informed EMI platform, or receive as-needed placebo with EMA-informed EMI. The 12-week treatment period is consistent …

Accepts healthy volunteers
  • 0 views
  • 10 Apr, 2022
  • 1 location