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Found 76 clinical trials
K0706 for Patients Diagnosed With Dementia With Lewy Bodies

This study evaluates the safety and tolerability of treatment with K0706 in Dementia with Lewy Bodies (DLB). The hypothesis is that K0706 will be safe and tolerable and that this drug will alter CSF and plasma biomarkers in DLB. Clinical assessments of cognitive, behavioral and motor functioning will also be …

rest tremor
parkinsonism
acetylcholinesterase
dementia
visual hallucinations
  • 79 views
  • 25 Jan, 2021
  • 1 location
Xenon Inhalation Therapy for Major Depressive Disorder and Bipolar Disorder

The investigators will test the hypothesis that inhaled xenon will produce a rapid improvement in depressive symptoms in patients suffering from treatment-resistant depression. Specifically, the investigators will conduct a parallel randomized, double-blind crossover study that will compare the effects of xenon-oxygen (35:65 ratio by volume) added to treatment as usual …

major depressive disorder
depressive symptoms
depression
bipolar disorder
antidepressants
  • 54 views
  • 23 Jan, 2021
This Phase 2 Double Blind Placebo-controlled Randomized Study is to Assess the Safety and Efficacy of Miricorilant in Obese Adult With Schizophrenia or Bipolar Disorder Treated With Antipsychotic Medications.

This phase 2, double blind, placebo-controlled, randomized study is to assess the safety and efficacy of miricorilant in obese adult with schizophrenia treated with antipsychotic medications.

  • 244 views
  • 29 Jan, 2021
  • 29 locations
Acute Effects of Exercise in College Students With ADHD

The overall objective of this study is to examine physical exercise as an intervention for ADHD. The rationale for the proposed study is that physical exercise could serve as an effective treatment for college students with ADHD that has low costs, low risks, and ancillary health benefits and may address …

cns stimulants
  • 75 views
  • 25 Jan, 2021
  • 1 location
Saxenda in Obese or Overweight Patients With Stable Bipolar Disorder (Investigator Initiated)

Taken together these data support the hypothesis that liraglutide 3.0 mg sc injection will reduce body weight and improve metabolic variables in obese or overweight patients with BP without worsening psychiatric symptoms. The investigators predict that liraglutide 3.0 mg sc injection will display greater efficacy as compared to placebo in …

psychotropic drugs
dyslipidemia
hypnotics
hypertension
antipsychotics
  • 525 views
  • 25 Jan, 2021
  • 1 location
Comparative Effectiveness of Pharmacogenomics for Treatment of Depression

The overall goal of this study is to assess the effectiveness of a widely available and widely used combinatorial pharmacogenomic (PGx) test for the treatment of major depressive disorder. Pharmacogenomic tests use genetic information to guide medication treatment decisions. The tests inform clinicians and patients of potential gene-drug interactions by …

psychotropic drugs
major depressive disorder
anxiety
depressed mood
depression
  • 0 views
  • 23 Jan, 2021
Evaluation of Efficacy and Safety of Long-acting Risperidone Microspheres in Patients With Schizophrenia or Other Psychotic Disorders When Switching From Typical Antipsychotic (Oral/Depot) or Atypical Oral Other Than Risperidone

The purpose of this study is to evaluate the efficacy, tolerability and safety of patients on long-acting Risperidone microshpheres injection. The major advantage of long-acting injection over oral medication is facilitation of compliance in medication taking. Non-compliance is very common among schizophrenic and is a frequent cause of relapse.

typical antipsychotic
schizophrenia
psychosis
risperidone
atypical antipsychotic
  • 30 views
  • 07 Nov, 2020
  • 1 location
A Clinical Study to Investigate the Effect of an Investigational Drug as an Added Medication to an Antipsychotic in Adults With Schizophrenia as Measured Positron Emission Tomography (PET) Imaging

A clinical study to investigate the effect of an investigational drug as an added medication to an antipsychotic, in adults with schizophrenia, as measured positron emission tomography (PET) imaging . This study is accepting male and female participants between 18 years old -45 years old who have been diagnosed with …

psychiatric disorder
prolactin
psychosis
clozapine
scid
  • 20 views
  • 26 Jan, 2021
  • 1 location
Do Antipsychotic Agents Induce Supersensitivity in Humans: A Combined PET/MRI Study in Patients With Schizophrenia

The aim of the present study is to detect changes in the dopamine system in the brain of patients with schizophrenia, especially when pretreated with antipsychotic medication. Here, the investigators want to find out whether the treatment with these drugs can cause permanent changes in docking points (receptors) of dopamine …

  • 0 views
  • 04 Mar, 2021
  • 1 location
Effects of Allopurinol on Inflammation and Ultrasonographic Changes in People With Elevated Uric Acid But no Symptoms

Hyperuricemia is a metabolic alteration defined as the presence of serum urate levels higher than 7 mg/dL. This has proven to be the maximum limit of solubility of urate in serum, any higher concentration leads to precipitation and eventually to the formation of monosodium urate (MSU) crystals. The accumulation of …

asymptomatic hyperuricemia
metabolic syndrome
Uric Acid Test
hypertension
gout
  • 1 views
  • 23 Jan, 2021
  • 2 locations