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Found 76 clinical trials
The Monitor of Serum Prolactin Level in a 3 Months Aripiprazole Trial

A short term post-market monitoring of serum prolactin level change among patients with schizophrenia shifting from other antispychotics to different dosages of aripiprazole.

  • 120 views
  • 07 Nov, 2020
  • 1 location
Repetitive Behavior Disorders in People With Severe Mental Retardation

Repetitive behavior disorders are prevalent among people with severe mental retardation. These disorders can interfere significantly with an individual’s daily functions. This trial is part of a long-term project that has studied the biologic basis of and possible treatments for repetitive behavior disorders. The trial will evaluate the effectiveness of …

severe mental retardation
behavioral disorder
selective serotonin reuptake inhibitor (ssri)
mental retardation
atypical antipsychotic
  • 32 views
  • 07 Nov, 2020
  • 2 locations
A 12-weeks Study to Evaluate the Dietary Fiber and Probiotics Treatment in Prevention and Intervention of Weight-gain and Cognitive Impairment of Schizophrenia or Bipolar Disorder

In this study, the investigators will evaluate the efficacy, safety and related mechanism of dietary fiber and probiotics alone and in combination as a add-on treatment in improving the antipsychotic induced weight gain, the cognitive impairment, and psychotic syndrome in schizophrenia or bipolar disorder patients. The study will recruit 100 …

schizophrenia
psychosis
cognitive impairment
bipolar disorder
antipsychotics
  • 67 views
  • 02 Feb, 2021
  • 1 location
Topiramate and Schizophrenia: Effects on Weight and Psychopathology

Clozapine is the sole AP agent with superiority in treatment refractory schizophrenia, but it also is associated with the greatest risk of weight gain and other metabolic abnormalities. Topiramate, an anticonvulsant agent, possesses a weight-reducing effect. Furthermore, some studies have suggested that Topiramate may be associated with improvements in psychopathology …

  • 14 views
  • 23 Jan, 2021
  • 1 location
Effect of Vortioxetine on Cognitive Symptoms in Patients With Schizophrenia

Research goals: Examination of the relationship between the use of vortioxetine and cognitive efficacy in patients with schizophrenia. Examination of the association between the use of vortioxetine and the presence depressive symptoms, physical and social anhedonia in patients with the disease from schizophrenia. Examining the association between vortioxetine use and …

schizophrenia
antipsychotics
vortioxetine
risperidone
  • 0 views
  • 24 Jan, 2021
  • 1 location
Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep

This study aims to determine whether, compared with placebo, the nighttime administration of a intravenous dexmedetomidine is effective at inducing sleep and preventing postoperative delirium in extubated post-cardiac surgical patients.

dexmedetomidine
cardiac operation
tracheal extubation
heart surgery
  • 15 views
  • 23 Jan, 2021
NRX100 vs. Placebo for Rapid Stabilization of Acute Suicidal Ideation and Behavior in Bipolar Depression

NMDA antagonist drugs have increasingly been demonstrated to reduce symptoms of depression and suicidal ideation. NeuroRx has developed a sequential therapy consisting of IV NRX-100 (ketamine HCL) for rapid stabilization of symptoms of depression and suicidal ideation followed by oral NRX-101 (fixed dose combination of D-cycloserine and lurasidone) for maintenance …

hypnotic
zolpidem
depression
electrocardiogram
anxiety
  • 92 views
  • 26 Jan, 2021
  • 2 locations
TICS: Transcranial Magnetic Stimulation for Intervening in Children With Tourette's Syndrome (CIHR)

Tourette's Syndrome (TS) is characterized by repetitive movements and vocalizations called tics. Due to the suffering caused by TS, children and adolescents often require treatment for their tics. The investigators' research focuses on developing novel repetitive transcranial magnetic stimulation (rTMS) interventions for child and adolescent neuropsychiatric disorders. In this project, …

tourette's syndrome
aminobutyric acid
transcranial magnetic stimulation
  • 0 views
  • 25 Jan, 2021
  • 1 location
Assessment of Efficacy of a Psychological Therapy in Inpatients With a Schizophrenic Psychosis

This randomised three-arm study aims to evaluate the efficacy and feasibility of a cognitive behavioral therapy (INT-Integrated Neurocognitive Therapy for Schizophrenia Patients) in the treatment of schizophrenia patients in an inpatient setting. The intervention will be compared with an active comparator (IPT- Integrated Psychological Therapy) and a control condition. Overall …

schizophrenia
schizoaffective disorder
psychosis
cognitive therapy
  • 4 views
  • 25 Jan, 2021
  • 2 locations
Study Evaluating the Safety Efficacy and Pharmacokinetics of Miricorilant in Obese Adult Patients With Schizophrenia While Taking Antipsychotic Medications (GRATITUDE II)

This Phase 2, double-blind, placebo-controlled, randomized study is to assess the safety and efficacy of miricorilant (CORT118335) in obese patients with schizophrenia treated with antipsychotic medications.

  • 0 views
  • 27 Jan, 2021
  • 17 locations