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Found 76 clinical trials
Decreasing Risk of Psychosis by Sulforaphane (DROPS Trial)

This is a randomized, double-blind, placebo-controlled, multi-centre trial. A total of 300 CHR subjects will be identified in the course of face-to-face interviews using the Structured Interview for Prodromal Syndromes. All participants will be randomly allocated to SFN group (n = 150) or placebo group (n = 150). The study …

  • 1 views
  • 25 Jan, 2021
  • 11 locations
Monitoring of Arrhythmias in Patients Treated With Antipsychotics

Antipsychotics may be associated to life-threatening arrhythmias and sudden cardiac death. This is the fist study to estimated the arrhythmic burden using long-term monitoring by implantable

  • 0 views
  • 02 Mar, 2021
  • 17 locations
Investigation of Sleep in the Intensive Care Unit

Sleep deprivation is common and severe in critically ill patients cared for in intensive care units (ICUs), and is hypothesized to be a key modifiable risk factor for delirium and long-term cognitive disability. Dexmedetomidine reduces the incidence of delirium in ICU patients by unknown mechanisms. This project will determine whether …

critical illness
mechanical ventilation
dexmedetomidine
  • 7 views
  • 24 Jan, 2021
Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

strategies following the onset of drug-induced movement disorders include neuroleptic discontinuation, use of atypical antipsychotics and anticholinergics. A pre-clinical study showed that the antioxidant

dopamine
antioxidants
structured clinical interview
anticholinergics
immunomodulator
  • 1 views
  • 23 Jan, 2021
  • 1 location
MAintain the Efficacy and Safety in Treatment of Schizophrenia After Switching to Long-acTing Injectable aRipiprazole From Oral Atypical Antipsychotics

safety in switching from oral atypical antipsychotics other than aripiprazole to Abilify Maintena

psychosis
clozapine
aripiprazole
antipsychotics
abilify
  • 47 views
  • 25 Jan, 2021
  • 27 locations
Molecular Mechanisms of Antipsychotic-induced Insulin Resistance

This study will investigate the molecular mechanisms of atypical-antipsychotic induced insulin resistance. This will be accomplished by administering olanzapine or placebo to healthy subjects for 7 days and analyzing genetic and protein changes in peripheral tissues known to play an important role in insulin resistance pathophysiology.

  • 17 views
  • 25 Jan, 2021
  • 1 location
Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia

Plasma half-life has routinely been used to establish the dosing schedule of antipsychotics; for example, it is recommended that agents with a short plasma half-life be administered multiple

clozapine
schizophrenia
schizoaffective disorder
antipsychotics
  • 123 views
  • 24 Jan, 2021
  • 1 location
Randomized Controlled Trial of Pyridoxine for Tardive Dyskinesia

Purpose: Tardive dyskinesia (TD) is a involuntary movement disorder that can occur following long term treatment with antipsychotic medications and for which few treatment options exist. This study will test the efficacy of pyridoxine (also known as vitamin B6) for TD. This will be an 8 week double-blind, placebo-controlled, randomized …

dopamine
involuntary movements
human chorionic gonadotropin
dopamine antagonist
schizophrenia
  • 204 views
  • 25 Jan, 2021
  • 1 location
Vildagliptin for Treatment of Antipsychotic-induced Dyslipidemia

Almost all antipsychotics can induce dyslipidemia, but no treatment has been established. Vildagliptin can improve lipid levels in obese patients. The investigators conducted a randomized

  • 0 views
  • 01 Mar, 2021
  • 1 location
Nighttime Agitation and Restless Legs Syndrome in People With Alzheimer's Disease

Nighttime agitation in persons with Alzheimer's disease causes patient suffering, distresses caregivers, and often results in prescriptions for harmful antipsychotics. Effective treatments are

dementia
agitation
severe dementia
cognitive impairment
  • 67 views
  • 27 Jan, 2021
  • 1 location