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Found 54 clinical trials
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A Study to Evaluate the Effects of Basmisanil in Participants With Cognitive Impairment Associated With Schizophrenia (CIAS) Treated With Antipsychotics.

This multicenter study will assess the effects of 24 weeks of basmisanil treatment on cognition and functioning of stable schizophrenia participants treated with antipsychotics.  

antipsychotics
schizophrenia disorders
  • 45 views
  • 22 Dec, 2020
  • 1 location
Pharmacogenetic Supported Prescribing in Kids

Implementation of pharmacogenetic testing for children and adolescents aged 7-17 who are starting or changing psychiatric medication.

  • 16 views
  • 23 Mar, 2021
  • 1 location
The Effect of Guanfacine on Delirium in Critically Ill Patients

cost, increased ventilator days, and long-term cognitive disability. Various pharmacologic agents including dopamine antagonists, acetylcholinesterase inhibitors, melatonin, antipsychotics, alpha-2

  • 17 views
  • 26 Nov, 2021
  • 1 location
Pilot Clinical Trial of an Integrative Intervention to Improve Critically Ill Patients' Delirium and Related Outcomes (REPOSE)

of sedatives, antipsychotics. Intervention: REPOSE intervention (a multimodal relaxation intervention) It includes: a) relaxation and guided imagery (RGI) (40 min, headphones), b) a

  • 0 views
  • 04 Oct, 2022
  • 1 location
A Randomized Controlled Double-Blind Trial for Prevention of Recurrent Ischemic Priapism in Men With Sickle Cell Disease: A Pilot Study (PIN)

To conduct a randomized controlled internal pilot feasibility trial for the prevention of recurrent ischemic priapism referred to as the Priapism in Nigeria (PIN) trial. The study team will enroll a minimum of 30 participants and a maximum of 200 participants. Study investigators hypothesize that hydroxyurea therapy combined with tadalafil …

  • 0 views
  • 15 Sep, 2022
  • 1 location
Monitoring of Arrhythmias in Patients Treated With Antipsychotics

Antipsychotics may be associated to life-threatening arrhythmias and sudden cardiac death. This is the fist study to estimated the arrhythmic burden using long-term monitoring by implantable

  • 1 views
  • 02 Mar, 2021
  • 17 locations
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)

Sleep deprivation is common and severe in critically ill patients cared for in intensive care units (ICUs), and is hypothesized to be a key modifiable risk factor for delirium and long-term cognitive disability. Dexmedetomidine reduces the incidence of delirium in ICU patients by unknown mechanisms. This project will determine whether …

critical illness
mechanical ventilation
dexmedetomidine
  • 13 views
  • 04 Mar, 2022
Antipsychotic Response to Clozapine in B-SNIP Biotype-1 (Clozapine)

The CLOZAPINE study is designed as a multisite study across 5 sites and is a clinical trial, involving human participants who are prospectively assigned to an intervention. The study will utilize a stringent randomized, double-blinded, parallel group clinical trial design. B2 group will serve as psychosis control with risperidone as …

risperidone
schizoaffective disorder
psychosis
schizophrenia
clozapine
  • 0 views
  • 12 Mar, 2022
  • 1 location
Safety and Pharmacokinetics of Antipsychotics in Children 2: Studying TDM in an RCT

The aim of this study is to test whether therapeutic drug monitoring of risperidone in children with autism spectrum disorder and comorbid behavioral problems is able to reduce metabolic side effect burden, while retaining clinical effectiveness.

  • 0 views
  • 16 Dec, 2021
  • 1 location
Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia

Plasma half-life has routinely been used to establish the dosing schedule of antipsychotics; for example, it is recommended that agents with a short plasma half-life be administered multiple

antipsychotics
schizoaffective disorder
schizophrenia
clozapine
  • 141 views
  • 23 Feb, 2022
  • 1 location