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Found 8 clinical trials
Candida PCR Diagnosis Strategy in Patients From Intensive Care Units (CANDI-PCR)

The aim of this study is to evaluate the implementation of a new technique for invasive candidiasis diagnosis by PCR. The main objective will be to evaluate the effect of this strategy on the time required to obtain results in patients from intensive care units with suspected systemic invasive candidiasis. …

  • 0 views
  • 04 Oct, 2022
  • 1 location
A Randomized Controlled Trial to Compare the Clinical Outcomes With Six Months of Therapy With Oral Itraconazole Versus Oral Voriconazole for Management of Treatment naïve Subjects With Chronic Pulmonary Aspergillosis

The current initial therapy for CPA is with six months of oral itraconazole. However, the response with six months of therapy has a response rate of 65-70% and has a relapse rate after stopping treatment of up to 50%. Voriconazole is a third-generation azole and a theoretical advantage of lower …

  • 7 views
  • 28 Jun, 2022
  • 2 locations
Study to Evaluate the Efficacy and Safety of Ibrexafungerp in Patients With Fungal Diseases That Are Refractory to or Intolerant of Standard Antifungal Treatment (FURI)

This is a multicenter, open label, non-comparator, single arm study to evaluate the efficacy and safety of ibrexafungerp (SCY-078) in patients ≥ 18 years of age with a documented fungal disease that has been intolerant or refractory (rIFI) to Standard of Care (SoC) antifungal treatment.

  • 183 views
  • 04 Oct, 2022
  • 36 locations
Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients

Early treatment of invasive fungal infections (IFI) may prevent undue mortality in acute on chronic liver failure (ACLF) patients. We aim to study the impact of early empiric treatment (based on clinical suspicion) of IFI as compared to pre-emptive treatment (based on biomarkers and culture positivity) on the outcomes in …

abdominal perforation
tuberculosis
immunosuppressant
SIRS
total parenteral nutrition
  • 2 views
  • 07 May, 2022
  • 1 location
Central Nervous System Disorders Following Hematopoietic Stem Cell Transplantation

. We will identify clinical and diagnostic characteristics such as cerebrospinal fluid (CSF) and neuroimaging patterns, risk factors, response to treatment (including novel antifungal agents

cell transplantation
colony stimulating factor
antifungal
  • 0 views
  • 20 Jun, 2022
  • 17 locations
Pharmacokinetics of Venetoclax in Patients With Chronic Lymphocytic Leukemia

Venetoclax is a treatment for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, the pharmacokinetic data in Chinese population, as well as the change of venetoclax plasma concentration while taking CYP enzyme inducers or inhibitors, remained unknown so far. Therefore, the aim of this study is to investigate …

cancer
chronic lymphocytic leukemia
venetoclax
  • 0 views
  • 03 Nov, 2021
  • 1 location
Pharmacokinetics of Venetoclax in Patients With Acute Myeloid Leukemia

Venetoclax is a treatment for chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). However, the pharmacokinetic data in Chinese population, as well as the change of venetoclax plasma concentration while taking CYP enzyme inducers or inhibitors, remained unknown so far. Therefore, the aim of this study is to investigate …

cancer
venetoclax
  • 0 views
  • 03 Nov, 2021
  • 1 location
Pharmacokinetics of Isavuconazole in Patients in the Intensive Care Unit (ICONIC)

20 patients admitted to the ICU department and receiving isavuconazole as part of standard care for the treatment of fungal infections will be included in the study. Between day 3 and 7, 8 samples will be collected at t = 0 (pre-dose), and t = 0.5, 1, 2, 4, 6, …

  • 0 views
  • 07 Oct, 2022
  • 4 locations