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Found 12 clinical trials
Symptom Management Efficacy Study to Reduce Distal Neuropathic Pain

nonnarcotic and narcotic analgesics, antidepressants and anticonvulsants, are largely ineffective. In HIV there are no FDA-approved drugs for this indication. This study assesses in a randomized controlled

pain relieving
  • 04 Nov, 2021
  • 1 location
Intravenous Methylprednisolone Versus Oral Prednisolone for Infantile Spasms (MPIV)

directed over the past years to evaluate the role of various anticonvulsants in the management of IS. High dose oral prednisolone has been shown to cause early cessation of spasms and resolution of

methylprednisolone oral
oral steroid therapy
epileptic spasms
oral prednisolone
  • 18 Feb, 2022
  • 1 location
The Study on the Esketamine in the Treatment of Postherpetic Neuralgia

herpes zoster heals and persists for a long time. At present, clinically anticonvulsants (such as gabapentin, pregabalin) and antidepressants (such as amitriptyline) are clinically first-line drugs for

  • 27 Jan, 2021
  • 1 location
Topiramate and Schizophrenia: Effects on Weight and Psychopathology

Clozapine is the sole AP agent with superiority in treatment refractory schizophrenia, but it also is associated with the greatest risk of weight gain and other metabolic abnormalities. Topiramate, an anticonvulsant agent, possesses a weight-reducing effect. Furthermore, some studies have suggested that Topiramate may be associated with improvements in psychopathology …

  • 23 Feb, 2022
  • 1 location
Effectiveness of Combined Levetiracetam and Midazolam in Generalized Convulsive Status Epilepticus in Children

Generalized status epilepticus is a common pediatric neurological emergency with significant mortality and morbidity. Benzodiazepines remain the first anticonvulsive line but benzo-diazepines don't control seizures in about 30% of cases. GCSE may be more rapidly stopped and controlled through combining another drug with benzodiazepines such as Levetiracetam, acting by different …

  • 18 Jul, 2021
  • 1 location
Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE) (TMD CARE)

Evaluate erenumab- aooe efficacy as a therapeutic approach, for the management of painful chronic temporomandibular disorders (TMD). The study will be a randomized, double blind, placebo-controlled trial comparing erenumab-aooe vs Placebo. A total of 60 patients (30 per each arm) aged 18-65 years old of either sex, and any race …

  • 14 May, 2022
  • 1 location
Botulinum Toxin Injections for Oral Neuropathic Pain (TRIGTOX)

Peripheral painful traumatic trigeminal neuropathy (PPTTN) are poorly relieved by existing treatments which in addition induce many adverse effects. BTX, which blocks the exocytosis of neurotransmitters, can be captured by axonal retrograde transport in primary nociceptive neurons. Injected in the painful area, it might therefore inhibit the release of algogenic …

  • 04 Feb, 2022
  • 1 location
Cannabidiol for Fibromyalgia (The CANNFIB Trial)

Fibromyalgia is serious chronic pain condition which is often accompanied by sleep disturbances, fatigue and disability and reduced quality of life. There is no cure and treatments are based on reliving symptoms and maintaining function. The currently available medical treatments are not helping many patients, and many get side-effects. Medical …

chronic pain
sham treatment
  • 20 Sep, 2021
  • 1 location
Neurofeedback Impact on Veterans With mTBI (NFBVETmTBI)

This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs). It is being funded by the Department of Veterans Affairs. Doing this study will help to determine if NFB will reduce …

traumatic brain injury
  • 24 Mar, 2022
  • 1 location
Defining Core Outcome Sets in Trigeminal Neuralgia (TRINCOS)

The aim of this study is to determine what patients with trigeminal neuralgia (TN), clinicians and researchers in the field, consider to be the most important outcomes to be expected after undergoing treatment for trigeminal neuralgia and how this could be measured in all studies relating to this condition. This …

  • 16 Mar, 2022