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Found 20 clinical trials
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Effectiveness of Antitussives Anticholinergics and Honey Versus Usual Care in Adults With Acute Bronchitis.

This study, which is aimed at comparing the effectiveness of 3 symptomatic therapies (dextromethorphan, ipratropium and honey) associated with usual care and the usual care in adults with acute bronchitis, is a multicentre, pragmatic, parallel group, open randomised trial. Patients aged 18 or over with uncomplicated acute bronchitis, with cough …

  • 0 views
  • 06 Sep, 2021
  • 12 locations
None
Comparative Efficacy and Safety of Sugammadex and Neostigmine

participants's vital signs. However, the reversal of acetylcholine ester inhibitors is slow, the curative effect has a ceiling effect, and the need to use anticholinergics (anticholinergics) to reduce the

  • 40 views
  • 10 Sep, 2021
  • 1 location
None
This is a Prospective Randomized Double-Blind Study Comparing Intravesical Injection of Botox to Placebo.

The current study will investigate the comparative efficacy, safety and patient satisfaction of intradetrusor injections BOTOX® injections (200U) versus placebo (saline) injections in the treatment of OAB secondary to benign prostatic obstruction (BPO).

intermittent catheterization
indwelling catheter
botox
intravesical injections
anticholinergic agents
  • 49 views
  • 07 Nov, 2020
  • 1 location
None
Investigation of Brain Mechanisms Involved in Urgency Urinary Incontinence

This is a randomized double-blind crossover trial of trospium and placebo in women with urgency urinary incontinence, with evaluation (history, physical, incontinence evaluation and brain MRI) at baseline, and after each course of therapy. The investigators will evaluate functional brain changes in relation to bladder improvement in order to improve …

  • 1 views
  • 10 Jun, 2021
  • 1 location
None
Intervention to REduce anticholinerGic burdEN in oldER pATiEnts (REGENERATE) Aged 65 Years and Older

Medications with anticholinergic properties are frequently prescribed for several conditions in older age; for example cardiovascular drugs (e.g. digoxin, furosemide), urologicals (e.g. darifenacin, oxybutynin) and anti-parkinsonism drugs (e.g. benztropine, trihexyphenadyl). It has been shown that increasing anticholinergic burden (ACB) can cause poor health-related outcomes, but there are still uncertainties around …

  • 0 views
  • 21 Sep, 2021
  • 1 location
None
OnabotulinumtoxinA for the Treatment of Urinary Incontinence Due to Overactive Bladder in Pediatric Patients (12 to 17)

17 years who have not been adequately managed with anticholinergics.

botox
onabotulinumtoxina
overactive bladder
anticholinergic agents
incontinence
  • 127 views
  • 30 Aug, 2021
  • 79 locations
None
Brain Safe: Consumer Intervention to Reduce Exposure to Drugs Linked to Alzheimer's Disease

prescribed one or more strong anticholinergics. Participants will be randomized to use the Brain Safe app or an attention control medication list app for 12 months, with monthly usage reminders.

alzheimer's disease
anticholinergics
anticholinergic agents
  • 1 views
  • 16 Feb, 2021
  • 3 locations
None
Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics

strategies following the onset of drug-induced movement disorders include neuroleptic discontinuation, use of atypical antipsychotics and anticholinergics. A pre-clinical study showed that the antioxidant

psychotropic drugs
structured clinical interview
immunomodulator
scid
antioxidants
  • 10 views
  • 23 Jan, 2021
  • 1 location
None
Percutaneous Posterior Tibial Nerve Stimulation in Post-operative Voiding Dysfunction After Deep Endometriosis Surgery

studies have explored the management of post-operative urinary complications after surgery for deep endometriosis. Pharmaceutical alternatives (alpha-blockers, anticholinergics, benzodiazepines) have not

  • 0 views
  • 07 Mar, 2021
  • 1 location
None
Mesenchymal Stem Cells for The Treatment of Chronic Obstructive Pulmonary Disease

The clinical study with UMC119-06 is designed to investigate the safety in patients with Chronic Obstructive Pulmonary Disease. This will be a dose escalation, open label, single-center study in adult with chronic obstructive pulmonary disease. UMC119-06 is ex vivo cultured human umbilical cord tissue-derived mesenchymal stem cells product which is …

  • 0 views
  • 01 May, 2021
  • 1 location