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Found 66 clinical trials
Antibiotic Prophylaxis Before Shock Wave Lithotripsy (APPEAL)

This is a two arm, double blind RCT comparing the use of a single dose ciprofloxacin prior to SWL to saline alone. The multicenter trial will be conducted with a pragmatic emphasis including both high volume and low volume sites internationally.

ciprofloxacin
antibiotics
antibiotic
shock
lithotripsy
  • 311 views
  • 15 Feb, 2022
  • 7 locations
Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

To determine the effectiveness of a 7-day course of an oral, prophylactic antibiotic on the incidence of periprosthetic joint infection and wound complications following primary total hip and knee arthroplasty in a high-risk patient population.

body mass index
diabetes
antibiotics
Accepts healthy volunteers
  • 5 views
  • 24 Mar, 2022
  • 1 location
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery

into one of two groups: group one will receive a preoperative placebo pill and group two will receive preoperative antibiotic prophylaxis (either a single dose of Cephalexin 2g PO or single dose of

  • 0 views
  • 31 May, 2021
  • 1 location
Prevention of Infections in Cardiac Surgery (PICS) Prevena Study (PICS-Prevena)

This vanguard study will be conducted at two study sites in Canada. It is a cluster randomized trial to test a combination of two antibiotics for antibiotic prophylaxis as compared to routine

cefazolin
antibiotic prophylaxis
antibiotics
sternotomy
wound care
  • 9 views
  • 07 Apr, 2022
  • 1 location
Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial. (ORALEV2)

The ORALEV Study found that preoperative oral antibiotics can reduce the incidence of surgical site infections after colonic resection, compared with no preparation. The role of mechanical bowel preparation in patients needing colonic surgery is yet to be elucidated. No randomised controlled trials have assessed the impact of mechanical bowel …

elective surgery
antibiotics
  • 0 views
  • 10 May, 2022
  • 8 locations
Single Dose Azithromycin to Prevent Cholera in Children

This study aims to determine whether single-dose azithromycin is effective in preventing cholera in children who are at extremely high risk of infection. The study will also determine the effect of this intervention on the development of antibiotic resistant bacteria. The results will inform future strategies to prevent cholera in …

Accepts healthy volunteers
  • 0 views
  • 17 Jun, 2022
  • 1 location
The Effect of Intrawound Vancomycin Powder in Spine Surgery

Problem: Postoperative wound infection following various spinal surgeries is a serious complication. The incidence of post-surgical wounds in spine surgery is high, and various researchers have reported different infection rates. In addition, increased healthcare costs, prolonged lengths of stay in hospital, and reduced quality of life as a result of …

  • 0 views
  • 16 May, 2022
  • 2 locations
Intra-Operative Electron Boost and Hypofractionated Whole-Breast Irradiation During Breast-conserving Treatment (BCT)

Title HIOB - Hypofractionated Whole-Breast Irradiation preceded by Intraoperative Radiotherapy with Electrons as anticipated Boost ISIORT- 01 HIOB is defined as hypofractionated WBRT (40,5 Gy in 2,7 Gy per fraction) preceded by an Intraoperative Boost to the tumor bed ( 90 % reference dose of 10 Gy, 11,1 Gy Dmax …

breast irradiation
breast cancer
carcinoma
cancer
  • 0 views
  • 28 Dec, 2021
  • 1 location
Dual Mobility Cups in Hip Fracture Patients (DUALITY)

Our aim is to develop a strategy that reduces the risk of dislocations after total hip arthroplasty surgery performed due to femoral neck fracture. We therefore perform a register-nested, pragmatic, randomized controlled trial to investigate the safety and efficacy of dual mobility cups that were designed to minimize the risk …

fracture of neck
hip arthroplasty
hip fracture
  • 0 views
  • 22 Apr, 2022
  • 1 location
Surgical Site Infection and Antibiotic Use Study

This study is a prospective, multi-institutional, noninferiority, randomized control trial that will compare the efficacy of two antibiotic treatments in preventing SSI in patients receiving immediate breast reconstruction with tissue expanders (TE-BR). The patients will be randomly assigned to one of the two treatment groups. One group will receive a …

  • 0 views
  • 02 Oct, 2021
  • 5 locations