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Found 147 clinical trials
Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections

Carbapenem-resistant (CR) Gram negative bacteria (GNB) - which are resistant to carbapenems (a last-line potent antibiotic with a high therapeutic index) - are also resistant to all other beta-lactam antibiotics. Most CRGNB are also extensively-drug resistant (XDR) (resistant to all classes of antibiotics except polymyxins and/or tigecycline) or pan-drug resistant …

  • 13 views
  • 24 Jan, 2021
  • 1 location
Single-dose PK Study of Ceftazidime-Avibactam In Hospitalized Children Receiving Systemic Antibiotics for Nosocomial Pneumonia

intravenous dose of CAZ AVI in pediatric subjects aged 3 months to less than 18 years who are receiving systemic antibiotic therapy for suspected or confirmed nosocomial pneumonia, including ventilator

  • 0 views
  • 19 Feb, 2021
  • 45 locations
C Difficile Near-patient Diagnostics

outcomes will compare turn-around times from specimen submission to result, days of hospitalization, the number of days of antibiotic therapy, the incidence of CDI, severe CDI, and in-hospital mortality. A

  • 0 views
  • 23 Jan, 2021
  • 2 locations
A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy

receiving doxycycline and in controls receiving standard antibiotic therapy, together with anti-plasma cell therapy. Patients will be assessed for parameters of plasma cell disease, heart involvement and

  • 26 views
  • 28 Jan, 2021
  • 8 locations
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP)

Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition. A growing body of evidence suggests that early recognition and treatment of sepsis can improve survival. Unfortunately, many …

  • 7 views
  • 24 Jan, 2021
  • 1 location
Antimicrobial Stewardship Interventions in a Hospital Setting

The emerging crisis of multidrug-resistant bacteria is accelerated by a massive overuse and misuse of antibiotics. It has been estimated that 50% of antibiotic prescriptions are inappropriate. Antibiotic interventions to improve prescribing patterns have been successfully implemented in primary care in Sweden and other countries. However, much of the last-resort …

  • 1 views
  • 24 Jan, 2021
  • 2 locations
Bezlotoxumab as Secondary Prophylaxis for C. Difficile in High-risk Hospitalized Patients Exposed to Antibiotics.

This study will examine whether the human monoclonal antibody, bezlotoxumab administered AFTER acute Clostridioides difficile (C.diff) has resolved, but during a period of subsequent antibiotic

  • 0 views
  • 26 Jan, 2021
  • 1 location
Short-course Antibiotic Treatment in Gram-positive Cocci Infective Endocarditis

. Subsequently, the vast majority of patients who overcome this acute phase has a favourable evolution, and usually stay in the hospital for a long time only to complete antibiotic therapy. In stable

  • 0 views
  • 18 Feb, 2021
  • 1 location
Partial Oral Antibiotic Treatment for Bacterial Brain Abscess

The investigators aim to determine if oral antibiotics are clinically acceptable as treatment of brain abscess. Following 2 weeks of standard intravenous antibiotic therapy, half of patients

  • 0 views
  • 29 Jan, 2021
  • 2 locations
Efficacy of Transvaginal Ultrasound-guided Aspiration for Treatment of Tubo-ovarian Abscess Compared With Laparoscopy

versus 65%) when antibiotic therapy is associated with abscess evacuation. TOA evacuation can be performed by surgery or by drainage. No studies have compared success rates between those two

  • 0 views
  • 24 Jan, 2021
  • 2 locations