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Found 17 clinical trials
Featured trial
  • 278 views
  • 25 Mar, 2021
  • 1 location
A Phase 2 Multicenter, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Safety and Efficacy of Lutikizumab (ABT-981) in Adult Subjects With Moderate to Severe Hidradenitis Suppurativa Who Have Failed Anti-TNF Therapy

patients who fail to achieve adequate benefit with anti-TNF therapy. This study will compare lutikizumab (ABT-981) versus placebo for the treatment of adult participants with moderate to severe HS who have

abscess
  • 46 views
  • 27 Oct, 2022
  • 47 locations
Interest of Continuous Non-Steroidal Anti-Inflammatory Drug Treatment in Ankylosing Spondylitis Patients Treated by Anti-TNF Therapy in the Prevention of Radiographic Outcomes (STOP)

Ankylosing spondylitis (AS) is a frequent chronic inflammatory rheumatic disease that affects the axial skeleton, starting in the sacroiliac joints and spreading to the spine in most patients. Non-steroidal anti-inflammatory drugs (NSAIDs) are the primary treatment for AS. Even if the use of anti-TNF agents has demonstrated good clinical efficacy …

arthritis
tumor necrosis factor
rheumatism
anti-tumor necrosis factor therapy
steroidal anti-inflammatory drugs
  • 236 views
  • 24 Mar, 2022
  • 16 locations
De-escalation of Anti-TNF Therapy in Inflammatory Bowel Disease (FREE)

necrosis factor (anti-TNF) therapy. As a result, 67 to 91% of paediatric patients and 66% of adult patients is still in sustained remission two years after the initiation of anti-TNF therapy. Prolonged use

crohn's disease
colitis
enteropathy
faecal calprotectin
inflammatory bowel disease
  • 0 views
  • 28 May, 2022
  • 1 location
The Immunogenicity and Safety of Zostavax® and Shingrix® in Rheumatoid Arthritis Patients Using Abatacept (BMS-188667)

patients using anti-TNF therapy is encouraging in that few patients experienced adverse events (56 adverse events in 50 participants, out of 140 participants in total) and that 96.2% of these adverse

arthritis
tumor necrosis factor alpha
hysterectomy
abatacept
attenuated vaccine
  • 157 views
  • 07 Oct, 2022
  • 4 locations
Adjunctive Treatment With Vitamin D3 in Patients With Active IBD (ACTIVATED)

pathway, suggesting a synergy with anti-TNF therapy. This is a randomized, double blind, placebo-controlled trial to study the effect of Vitamin D3 as an adjunct therapy for patients with active CD

crohn's disease
vitamin
enteropathy
cancer
cholecalciferol
  • 0 views
  • 27 Apr, 2022
  • 1 location
The Immunogenicity and Safety of Shingrix Vaccine in Patients With Moderate to Severe Ulcerative Colitis on Tofacitinib

on anti-tumor necrosis alpha (anti-TNF) monotherapy, and superior to those on anti-TNF therapy in combination with a thiopurine. Strong cell mediated immunity is shown to prevent reactivation of HZ

mercaptopurine
tumor necrosis factor
colitis
enteropathy
thiopurines
  • 49 views
  • 12 Oct, 2022
  • 1 location
Boosting Biologics in Ulcerative Colitis

This study evaluates the safety of the probiotic compound IDOFORM TRAVEL® in patients with ulcerative colitis undergoing anti-TNF treatment with insufficient clinical response. Furthermore, the study aims to explore the composition of the bacteria of the gut as well as the immunological activity in patients with ulcerative colitis undergoing anti-TNF …

tumor necrosis factor
colitis
endoscopy
enteropathy
Accepts healthy volunteers
  • 3 views
  • 17 Oct, 2022
  • 1 location
Regulation of Mucosal Healing in Inflammatory Bowel Disease

The objective of the current study is to compare non-healing colonic ulcers in patients with inflammatory bowel disease (IBD) with iatrogenic colonic ulcers (biopsy sites) in healthy control patients and patients with rheumatoid or psoriatic arthritis. Patients will be biopsied at baseline and again at a follow-up visit in a …

crohn's disease
tumor necrosis factor
colitis
Accepts healthy volunteers
enteropathy
  • 0 views
  • 18 Oct, 2022
  • 1 location
Comparison of Trough Level- and Clinical-based Spacing of Infliximab Infusions in Patients With IBD in Deep Remission (SPACIFIX)

Comparison of trough level-based spacing and clinical-based spacing of infliximab infusions in patients with inflammatory bowel disease in deep remission A prospective, multicenter, open-label, randomized, controlled Study

crohn's disease
colitis
endoscopy
enteropathy
remission
  • 1 views
  • 15 Feb, 2022
  • 13 locations