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Found 40 clinical trials
Featured trial
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

myelodysplastic syndromes
anemia studies
myelodysplastic syndrome (mds)
aplastic anemia
anemia
  • 54 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

of the National Institutes of Health Clinical Center and will receive regular doses of cyclophosphamide, fludarabine, and anti-thymocyte globulin to suppress their immune system and prepare for the

myelodysplastic syndromes
anemia studies
myelodysplastic syndrome (mds)
aplastic anemia
anemia
  • 194 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

myelodysplastic syndromes
anemia studies
myelodysplastic syndrome (mds)
aplastic anemia
anemia
  • 172 views
  • 22 Dec, 2020
  • 1 location
TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation

This study will determine whether a preparatory regimen including total lymphoid irradiation (TLI), total body irradiation (TBI), anti-thymocyte globulin (ATG) and infusion of the donor

  • 6 views
  • 27 May, 2022
  • 2 locations
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at a lower dose of CsA with EPAG before

blood test
immunosuppressant
antithymocyte globulin
reticulocyte count
cyclosporine
  • 12 views
  • 04 Oct, 2022
  • 1 location
Cryopreserved Polyclonal Regulatory T Cell (cePolyTregs) Immunotherapy in Islet Transplantation (cePolyTregs)

The transplant of the insulin-producing cell into the liver (Islet transplant) has been proven an effective and valuable treatment for type 1 diabetics patients with poor blood sugar. However, Islet transplant is currently limited by the number of pancreas organ donors and the need for lifelong medication requirements such as …

  • 0 views
  • 14 Oct, 2022
  • 1 location
MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D) (Meld-ATG)

A phase II, Multi-centre, randomised, double-blind, placebo-controlled, Multi-arm parallel cohort trial. to investigate the effect of 2.5 mg/kg og ATG on the preservation of stimulated C-peptide at 12 months compared to placebo to identify the minimally effective dose of ATG that shows an effect on C-peptide when compared to placebo …

  • 0 views
  • 17 Mar, 2022
  • 5 locations
A Modified Dose of Rabbit Anti-thymocyte Globulin (rATG) in Children and Adults Receiving Treatment to Help Prepare Their Bodies for a Bone Marrow Transplant

The purpose of this study is to see if conditioning regimens that include personalized rabbit ATG (P-rATG) help the immune system recover sooner and decrease the chances of transplant-related side effects. Participants in this study will be children and adults who have acute leukemia or myelodysplastic syndrome (MDS), and will …

leukemia
total body irradiation
melphalan
acute leukemia
bone marrow transplant
  • 0 views
  • 07 Oct, 2022
  • 1 location
ATG Plus PTCy vs ATG for CGVHD Prophylaxis

A Randomized Pilot Trial to test the feasibility of comparing anti-thymocyte globulin plus post transplant cyclophosphamide with anti-thymocyte globulin alone to prevent chronic graft versus

hla-a
thymoglobulin
remission
myeloid leukemia
leukemia
  • 0 views
  • 07 Sep, 2021
  • 10 locations
TReatment for ImmUne Mediated PathopHysiology (TRIUMPH)

will determine if suppressing inflammatory responses with either corticosteroids or equine anti-thymocyte globulin therapy improves survival for children with this rare, life-threatening condition.

mediators
encephalopathy
corticosteroids
liver injury
  • 0 views
  • 04 Oct, 2022
  • 11 locations