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Found 31 clinical trials
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Symptomatic Management of Lyme Arthritis

Lyme arthritis resolves with appropriate antimicrobial treatment in a majority of patients, but 10-20% of patients develop antibiotic-refractory Lyme arthritis with prolonged arthritis symptoms and treatment courses. Excessive up-regulation of the inflammatory process has been shown in patients with antibiotic-refractory Lyme arthritis. The over-expressed pro-inflammatory cell mediators are downstream of …

antibiotics
cytokines
antibiotic therapy
arthritis
mediators
  • 58 views
  • 20 Nov, 2021
  • 1 location
None
Abatacept vs Tocilizumab for the Treatment of RA in TNF Alpha Inhibitor Inadequate Responders

Rheumatoid arthritis (RA) is the most common inflammatory rheumatoid disease in France, affecting 0.3% of the general population. Without effective treatment, the persistent inflammation causes invalidating pain and joint destruction, leading to major functional disability. Biological agents have been proposed for patients with RA who have the most severe form …

roactemra
tumor necrosis factor
abatacept
antirheumatics
tumor necrosis factor inhibitors
  • 11 views
  • 22 Jan, 2021
  • 1 location
None
Comparative Evaluation of A-CP HA Kit Hyaluronic Acid and Placebo for the Treatment of Knee Osteoarthritis

Hyaluronic acid (HA) is a major component of synovial fluid, to which it confers viscosity and elasticity. It has been shown that the rheological properties of the synovial fluid decrease in patients with osteoarthritis. Intra-articular injections of hyaluronic acid represents a commonly used therapeutic option to relieve osteoarthritic symptoms, by …

osteoarthritis
knee pain
intra-articular injection
analgesics
hyaluronic acid
  • 40 views
  • 28 Jan, 2021
  • 1 location
None
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients

The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF- or JAK OR physical training of hands has positive impact on neuropsychiatric symptoms and morphological changes in the brain caused by the disease. The goal of this …

  • 0 views
  • 16 Apr, 2021
  • 1 location
None
The Norwegian Antirheumatic Drug Register

modifying anti-rheumatic drugs (DMARDs) in clinical practice, by measuring disease activity, health related quality of life, function and joint damage, and to study the long-term safety of such treatment

  • 10 views
  • 21 Jan, 2021
  • 7 locations
None
Microbiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitor

establish validated predictors of response to disease-modifying anti-rheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA). JAK inhibitors is a new class of DMARDs with great efficacy that

antirheumatics
baricitinib
rheumatism
tumor necrosis factor
tofacitinib
  • 0 views
  • 07 Sep, 2021
  • 1 location
None
Identification of New Biomarkers to Promote Personalized Treatment of Patients With Inflammatory Rheumatic Diseases

-rheumatic drugs (bDMARDs). However, bDMARD treatment failure occurs in 30-40% of patients due to lack of effectiveness or side effects. The tools to predict treatment outcomes in the individual patient are

connective tissue disorder
spondyloarthropathy
psoriatic arthritis
connective tissue diseases
rheumatoid arthritis
  • 286 views
  • 24 Jan, 2021
  • 12 locations
None
Comparative Effectiveness of Targeted Therapy in RA Patients

The objective of a multicenter prospective observational study is to compare effectiveness and safety of biologic disease-modifying antirheumatic drugs and small molecular inhibitors in patients with moderately to severely active rheumatoid arthritis patients who have had an inadequate response or intolerace to methotrexate.

etanercept
abatacept
antirheumatics
baricitinib
rheumatism
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Biobank for Inflammatory Chronic Diseases and Osteoporosis

The aim of this study is to constitute a biobank for patients followed in the Rheumatology center of Toulouse University Hospital for a chronic inflammatory rheumatism including rheumatoid arthritis (RA), spondyloarthritis(SpA), and psoriatic arthritis (PsA) or a chronic bone disease including osteoporosis in order to identify biomarkers associated with therapeutic …

arthritis
secondary osteoporosis
osteoporosis
rheumatism
psoriatic arthritis
  • 0 views
  • 26 Sep, 2021
  • 1 location
None
Golimumab for Adherence in Rheumatoid Arthritis

The purpose of this study is to determine if non-adherence to Rheumatoid Arthritis (RA) drugs in participants treated with biologic disease modifying anti-rheumatic drugs (DMARDs) is associated

antirheumatics
rheumatic diseases
golimumab
DMARD
  • 227 views
  • 08 Dec, 2021
  • 38 locations