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Found 12 clinical trials
Featured trial
Healthy MY 3853-0007

ICON Early Phase Services is conducting a research study for healthy adults ages 18-45. This study is being done to test a potential anti-fungal drug.

  • 745 views
  • 09 Jun, 2020
  • 1 location
Featured trial
A 3-week study to evaluate a topical anti-fungal cream that is approved for use in adults.

A 3-week study to evaluate a topical anti-fungal cream that is approved for use in adults.

  • 333 views
  • 08 Nov, 2020
  • 1 location
Anti-fungal Strategies in Acute-on-Chronic Liver Failure Patients

Early treatment of invasive fungal infections (IFI) may prevent undue mortality in acute on chronic liver failure (ACLF) patients. We aim to study the impact of early empiric treatment (based on clinical suspicion) of IFI as compared to pre-emptive treatment (based on biomarkers and culture positivity) on the outcomes in …

abdominal perforation
renal failure
prophylaxis
antibiotics
antibiotic therapy
  • 2 views
  • 07 May, 2022
  • 1 location
Terbinafine Treatment of Axial Spondyloarthropathy

This is a pilot study to determine if further research is warranted to assess if anti-fungal therapy is an effective adjunctive treatment for axial spondyloarthropathy

spondyloarthropathy
spondyloarthropathies
axial spondyloarthritis
  • 17 views
  • 21 Nov, 2021
  • 1 location
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

pathways are activated in a significant proportion of esophageal cancers. Itraconazole, a widely used anti-fungal medication, has been shown to inhibit various pathways involved in esophageal cancer

cancer
esophageal cancer
AKT
carcinoma
adjuvant therapy
  • 2 views
  • 12 Feb, 2022
  • 1 location
Phase 1 Study of Ibrutinib and Immuno-Chemotherapy Using Temozolomide, Etoposide, Doxil, Dexamethasone, Ibrutinib, Rituximab (TEDDI-R) in Primary CNS Lymphoma

BACKGROUND Primary CNS lymphoma (PCNSL) is a rare subtype of diffuse large B-cell lymphoma. The outcome for patients with this diagnosis is significantly worse than for that of systemic DLBCL. Most treatment approaches in the past have included high dose methotrexate and radiation treatment. Most PCNSLs appear to be of …

ejection fraction
oophorectomy
nervous
dexamethasone
rituximab
  • 18 views
  • 24 Oct, 2022
  • 1 location
Clinical Evaluation of a New Form of Cancer Therapy (Atavistic Chemotherapy) Based on the Principles of Atavistic Metamorphosis (2011)

The cell behavior that the investigators regard as "malignant," including: cell autonomy; invasion and digestion of surrounding normal tissues; migration and colonization of distant organs; ability to develop resistance to drugs, temperature, or radiation; and ability to kill the host, are not only characteristics of cancer cells, but of pathogenic …

primary cancer
cancer treatment
metastasis
combinations
tumor markers
  • 30 views
  • 26 Apr, 2022
  • 1 location
Safety and Effectiveness of the PXL Platinum 330 System With Riboflavin Solution for Refractory Corneal Ulcers

This study is being conducted to evaluate the safety and effectiveness of using the PXL Platinum 330 System with riboflavin solution for performing corneal collagen crosslinking (CXL) for the treatment of refractory corneal ulcers. The PXL Platinum 330 System is a combination product consisting of an ultraviolet-A (UV-A) 365 nm …

  • 0 views
  • 11 Oct, 2022
  • 8 locations
Neuro-pharmacological Study of Ketoconazole for High-grade Gliomas

This research is being done to find out if the study drug (ketoconazole) can enter brain tumors at a high enough amount to stop the tumor cells from dividing. Ketoconazole is a drug which doctors already use for fungal infections and is thought to be able to effect tumor cells. …

brain tumor
tumor cells
EGFR
  • 0 views
  • 04 Oct, 2022
  • 1 location
Neuro-pharmacological Properties of Repurposed Posaconazole in Glioblastoma: A Phase 0 Clinical Trial

This research is being done to find out if the study drug (posaconazole) can enter brain tumors at a high enough amount to stop the tumor cells from dividing. Posaconazole is a drug which doctors already use for fungal infections and is thought to be able to effect tumor cells. …

brain tumor
tumor cells
  • 0 views
  • 04 Oct, 2022
  • 1 location