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Found 19 clinical trials
Intraoperative Aromatherapy Versus Placebo for Port-a-Cath Placement Under Monitored Anesthesia Care. A Randomized Controlled Trial

This is a prospective, controlled, randomized trial. Primary objective is to compare the time to readiness for discharge (minutes) from Post-Anesthesia Care Unit (PACU) after Port-a-Cath placement surgery between patients who are randomized to receive intraoperative aromatherapy versus placebo. 70 Eligible subjects will be identified from within the patient population …

anesthesia
  • 0 views
  • 05 Jun, 2022
  • 1 location
Multidisciplinary Perioperative Care Pathway in Adolescents Undergoing Posterior Spinal Fusion Surgery

Posterior Spinal fusion (PSF) is one of the most invasive orthopedic surgical procedures in children and adolescents, often characterized by extensive tissue trauma, and severe postoperative pain. In addition to pain, the postoperative period is complicated by the side effects of opioids such as nausea and vomiting, itching and sedation. …

nausea
elective surgery
analgesics
vomiting
gabapentin
  • 1 views
  • 08 Aug, 2021
  • 1 location
Dexamethasone in Total Knee Arthroplasty

The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.

Accepts healthy volunteers
  • 0 views
  • 11 Mar, 2022
  • 5 locations
BMT-08: A Comparative Effectiveness Study of Transdermal Granisetron to Ondansetron

Patients undergoing either an autologous or allogeneic hematopoietic stem cell transplant (HSCT) and receiving preparative chemotherapy experience a considerable amount of chemotherapy-induced nausea and vomiting (CINV). Current strategies at reducing CINV in this patient population are suboptimal due to lack of efficacy and supportive evidence, potential for increased adverse events, …

quetiapine
butyrophenone
nausea
granisetron
dexamethasone
  • 1 views
  • 16 Jun, 2022
  • 1 location
Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ

The purpose of the study is to estimate the ability of mirtazapine to reduce depression, nausea, and vomiting, and maintain weight in depressed glioma patients undergoing Temozolomide (TMZ) therapy. Of equal importance, the investigators will monitor the tolerability of Mirtazapine in these patients over the course of the study.

  • 1 views
  • 06 Feb, 2022
  • 1 location
Pre-emptive Intravenous Morphine for Acute Post-craniotomy Pain.

We propose a double-blind randomized controlled trial to evaluate the effect of intravenously administered morphine at surgery conclusion on acute postoperative pain in patients recovering from craniotomy surgery. Participating adults having craniotomy surgery will be randomized in a 1:1 ratio to intraoperative intravenous administration of 0.08 mg/kg morphine at dura …

postoperative pain
morphine
body mass index
  • 0 views
  • 13 Mar, 2022
Toward a Computationally-Informed, Personalized Treatment for Hallucinations

Auditory hallucinations are among the most distressing aspects of psychotic illness, and between 10 and 30% of people with hallucinations do not respond to antipsychotic medications. The authors have used computational modeling of behavior to link brain activity to development of auditory hallucinations in the hope of guiding new treatment …

brief psychotic disorder
schizophrenia
schizoaffective disorder
hallucinations
  • 0 views
  • 14 Mar, 2022
  • 1 location
Comparing TAP Blocks Bupivacaine, and Placebo for Plane (CLEVELAND)

The study will prospectively compare the analgesic efficacy of TAP blocks with liposomal bupivacaine, plain bupivacaine, and placebo in patients who are scheduled for major abdominal surgery. The primary aim is to assess the duration of the local analgesia (determined by pinprick and cold) in all four quadrants. Comparing opioid …

  • 0 views
  • 15 Mar, 2022
  • 1 location
CBD Oil for Reducing Emotional Impact of COVID-19 (CBDOIL)

The overarching objective of the proposed project is to test the relative clinical efficacy of CBD isolate, full-spectrum CBD oil, broad-spectrum CBD oil, and placebo oil in reducing COVID-induced stress (anxiety, depression, anger, substance use, and sleep disturbance).

Accepts healthy volunteers
  • 39 views
  • 15 Jun, 2022
  • 1 location