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Found 64 clinical trials
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Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR

using a contrast-enhanced (CE) cardiac magnetic resonance imaging(CMR) which included the measurement of T1 mapping, T2 mapping, T2* mapping and late gadolinium enhancement(LGE) sequences, as well as LVEF and extracellular volume(ECV) to evaluate the respective changes before and after anthracycline chemotherapy.

cancer chemotherapy
chemotherapy regimen
anthracyclines
myocardial injury
MRI
  • 5 views
  • 25 Jan, 2021
  • 1 location
None
Genomic and Epigenomic Alterations After Cancer Treatment in Pregnancy

The investigators want to obtain a fundamental understanding if and which chemotherapeutic agents used for treating cancer during pregnancy are associated with placental and/or offspring (epi)genetic changes, potentially causing FGR and childhood/adult diseases later in life.

anthracyclines
cancer
cancer treatment
antineoplastic agents
cyclophosphamide
  • 0 views
  • 14 May, 2021
  • 1 location
None
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy

The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes. However, cardiac toxicity remains a substantial concern. Conventionally, this toxicity has been considered as a transient and reversible phenomenon occurring in the …

trastuzumab
her2/neu-positive breast cancer
erbb2
HER2
  • 0 views
  • 30 Aug, 2021
  • 1 location
None
A Study of Limited Heart Monitoring During Non-anthracycline Trastuzumab-based Therapy in Breast Cancer Patients

The purpose of this study is to test whether patients with breast cancer who are being treated with non-anthracycline trastuzumab therapy can safely be monitored for heart related side effects less often than usual.

erbb2
breast carcinoma
anthracyclines
carcinoma
her2/neu-positive breast cancer
  • 44 views
  • 17 Oct, 2021
  • 8 locations