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Found 61 clinical trials
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The Swiss Childhood Cancer Survivor Study - Follow-up (SCCSS-FollowUp)

The SCCSS-FollowUp is a national, multicenter cohort study designed to investigate late effects in childhood cancer survivors in a prospective and longitudinal way. The study is embedded in regular follow-up care and inclusion in the study takes place in a step-wise approach. The investigators collect data from clinical examinations, laboratory …

  • 0 views
  • 03 Feb, 2021
  • 3 locations
None
Investigating Cardiovascular Adverse Events Related to Cancer Treatment

Cisplatin, anthracyclines, bleomycin and trastuzumab can cause severe cardiovascular or pulmonary toxicity. Why some patients are susceptible to extreme toxicity of cancer treatment is largely

  • 1 views
  • 25 Jan, 2021
  • 1 location
None
Predictors of Response to Neoadjuvant Docetaxel-Carboplatin Chemotherapy for Patients With Stage II and III Triple Negative Breast Cancer

including anthracyclines and taxanes, with pCRs of 28-32%. Only recently, the results of a few small trials combining platinum salts and taxanes have been reported, with encouraging results (pCR of 44-77

HER2
triple negative breast cancer
carboplatin
breast carcinoma
breast cancer staging
  • 0 views
  • 04 Sep, 2021
  • 1 location
None
Cardiac Dysfunction in Childhood Cancer Survivors

This single center, prospective cohort study evaluates early cardiac dysfunction in adult survivors of childhood cancer. The hypothesis of this study is that cardiac dysfunction can be detected earlier when using speckle tracking echocardiography as novel echocardiographic technique compared to conventional echocardiography.

cancer diagnosis
cancer
  • 0 views
  • 23 Jan, 2021
  • 1 location
None
Randomised Controlled Study of Physical Exercise Intervention in Breast Cancer Patients at Risk of Anthracycline-induced Cardiomyopathy: The EMBRACE Study

Cardiomyopathy is a condition that affects the heart muscle, whereby it becomes enlarged, thick or rigid. When the heart muscle becomes involved, it affects the pumping action of the heart. This condition can affect as many as 10% of all patients after undergoing anthracycline cancer drug therapy and unfortunately carries …

anthracyclines
Accepts healthy volunteers
antineoplastic
  • 7 views
  • 06 Oct, 2021
  • 1 location
None
CTC Changes and Efficacy of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer

Chemotherapy before operation for malignant tumors can reduce the size of tumors to a certain extent, even eliminate micrometastases. Chemotherapy can also detect the sensitivity of chemotherapeutic drugs and create opportunities for breast-conserving or surgical treatment for patients. This may lead to high survival opportunities for triple-negative breast cancer patients …

endocrine therapy
hormone therapy
paclitaxel
cancer chemotherapy
breast cancer
  • 1 views
  • 28 Jan, 2021
  • 2 locations
None
Study of Prediction of Ovarian Reserve in Yong Breast Cancer Patients Treated With Chemotherapy

The purpose of this study is to predict the ovarian reserve, especially premature ovarian insufficient (POI), in young breast cancer patients during chemotherapy treatment using ultrasensitive anti-Mllerian hormone (AMH) detection method.

  • 0 views
  • 28 Feb, 2021
  • 1 location
None
Evaluation of Myocardial Injury After Anthracycline Chemotherapy in Osteosarcoma Patients Using CMR

using a contrast-enhanced (CE) cardiac magnetic resonance imaging(CMR) which included the measurement of T1 mapping, T2 mapping, T2* mapping and late gadolinium enhancement(LGE) sequences, as well as LVEF and extracellular volume(ECV) to evaluate the respective changes before and after anthracycline chemotherapy.

MRI
anthracyclines
myocardial injury
chemotherapy regimen
cancer chemotherapy
  • 5 views
  • 25 Jan, 2021
  • 1 location
None
Genomic and Epigenomic Alterations After Cancer Treatment in Pregnancy

The investigators want to obtain a fundamental understanding if and which chemotherapeutic agents used for treating cancer during pregnancy are associated with placental and/or offspring (epi)genetic changes, potentially causing FGR and childhood/adult diseases later in life.

primary cancer
cyclophosphamide
cancer
anthracyclines
cancer treatment
  • 0 views
  • 14 May, 2021
  • 1 location
None
Investigating the Long-term Cardiac Sequelae of Trastuzumab Therapy

The introduction of trastuzumab for the treatment of patients with human epidermal growth factor receptor 2 (HER2) positive breast cancer has had a major impact upon cancer outcomes. However, cardiac toxicity remains a substantial concern. Conventionally, this toxicity has been considered as a transient and reversible phenomenon occurring in the …

HER2
erbb2
her2/neu-positive breast cancer
trastuzumab
  • 0 views
  • 30 Aug, 2021
  • 1 location