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Found 61 clinical trials
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International Study for Treatment of High Risk Childhood Relapsed ALL 2010

The main goal of this study is to improve the outcome of children and adolescents with acute lymphoblastic leukemia with high risk first relapse by optimization of treatment strategies within a large international trial and the integration of new agents.

  • 10 views
  • 25 Jan, 2021
  • 19 locations
None
Platinum and Polyadenosine 5'Diphosphoribose Polymerisation (PARP) Inhibitor for Neoadjuvant Treatment of Triple Negative Breast Cancer (TNBC) and/or Germline BRCA (gBRCA) Positive Breast Cancer

This neoadjuvant trial for patients with TNBC and/or gBRCA breast cancer, aims to investigate the safety and efficacy (improvement in pathological Complete Response at surgery) of concurrent platinum-based chemotherapy with olaparib an inhibitor of the PARP enzyme (PARPi).

EGFR
erbb2
adjuvant therapy
triple negative breast cancer
carboplatin
  • 17 views
  • 21 Jan, 2021
  • 1 location
None
To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH)

This is a phase II open-label, multicentre, randomized trial. The study assesses the treatment of postmenopausal patients with hormone receptor positive/HER2 positive early breast cancer with neoadjuvant palbociclib in combination with hormonal therapy and HER2 blockade, versus the treatment with paclitaxel in combination with HER2 blockade.

erbb2
palbociclib
primary tumor
trastuzumab
mammogram
  • 17 views
  • 26 Oct, 2021
  • 63 locations
None
A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. Monoclonal antibodies, such as blinatumomab, may induce changes in the body's immune system and may interfere with the ability …

doxorubicin
asparaginase
white blood cell count
monoclonal antibody therapy
pegaspargase
  • 84 views
  • 05 Dec, 2021
  • 119 locations
None
Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses

The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.

doxorubicin
anthracyclines
adjuvant chemotherapy
cancer
cyclophosphamide
  • 0 views
  • 10 Oct, 2021
  • 1 location
None
Nab-paclitaxel Compared With Docetaxel Followed by Anthracyclines and Cyclophosphamide in the Neoadjuvant Breast Cancer

This study is an open, multicenter, randomized controlled clinical trial for patients with newly diagnosed primary invasive breast cancer and clinical stage of T2 or above. The main purpose of this study is to evaluate the efficacy of dose-dense nab-paclitaxel compared with dose-dense docetaxel followed by anthracycline and cyclophosphamide in …

docetaxel
erbb2
anthracyclines
cyclophosphamide
paclitaxel
  • 1 views
  • 23 Jan, 2021
  • 1 location
None
Evaluation of Sequencing of Anthracyclines and Taxanes for Locally Advanced HER2-negative Breast Cancer

Phase III randomized clinical trial evaluating the sequencing of anthracyclines and taxanes in neoadjuvant therapy for locally advanced HER2-negative breast cancer.

doxorubicin
erbb2
anthracyclines
breast carcinoma
paclitaxel
  • 0 views
  • 10 Sep, 2021
  • 10 locations
None
Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines

anthracyclines. Donor bone marrow derived mesenchymal stem cells may help to control symptoms of heart failure and improve heart function.

medical therapy
cardiomyopathy
trastuzumab
walk test
heart failure
  • 0 views
  • 14 Oct, 2021
  • 1 location
None
Pegliposomal Doxorubicin and 5-fluorouracil as Second Line Therapy for Metastatic Gastric Cancer

For second-line chemotherapy for metastatic gastric cancer, single-agent irinotecan is the standard treatment. Anthracyclines are active but lack well designed investigations. The combination of

cancer chemotherapy
doxorubicin
solid tumor
anthracyclines
irinotecan
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
A Study of RC48-ADC for the Treatment of Locally Advanced or Metastatic Breast Cancer With Low Expression of HER2

This study will compare RC48-ADC to physician choice standard treatment. Participants must have HER2-low breast cancer previous use of anthracyclines, and have been treated with one or two

capecitabine
endocrine therapy
erbb2
anthracyclines
adjuvant chemotherapy
  • 0 views
  • 01 Dec, 2021
  • 1 location