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Found 61 clinical trials
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RNA Disruption Assay (RDA)-Breast Cancer Response Evaluation for Individualized Therapy

The current study aims to provide validation results of RNA Disruption Assay (RDA) as a tumour response assessment tool that uses tumour core biopsies taken starting from 35 +/- 4 days after the initiation of neoadjuvant chemotherapy.

adjuvant therapy
breast cancer
invasive breast cancer
cancer
  • 28 views
  • 28 May, 2021
  • 36 locations
None
Neoadjuvant Treatment of HER2 Positive Early High-risk and Locally Advanced Breast Cancer

n the present study the neoadjuvant approach with the anti-HER2 trastuzumab and pertuzumab combined with carboplatin and paclitaxel will be used to compare the Event-Free Survival (EFS) in regimens with and without atezolizumab. Following the neoadjuvant part of the study, after surgery all patients will continue to receive trastuzumab and …

progesterone receptor
estrogen
HER2
cyclophosphamide
trastuzumab
  • 21 views
  • 27 Nov, 2021
  • 56 locations
None
Xeloda Plus Paclitaxel in Gastric Cancer With Liver Metastasis

To investigate the efficacy of capecitabine combined with paclitaxel as neoadjuvant chemotherapy for gastric cancer with liver metastasis only

capecitabine
xeloda
metastasis
liver metastasis
cancer chemotherapy
  • 16 views
  • 08 Nov, 2020
  • 1 location
None
Neoadjuvant Study Chemotherapy vs Letrozole + Abemaciclib in HR+/HER2- High/Intermediate Risk Breast Cancer Patients

Phase II, randomized, open-label, international, multicenter study to compare efficacy of standard chemotherapy vs. letrozole plus abemaciclib as neoadjuvant therapy in HR-positive/HER2-negative high/intermediate risk breast cancer patients

  • 0 views
  • 19 Nov, 2021
  • 28 locations
None
Remote Ischemic Conditioning in Oncology

This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. Patients undergoing anthracycline chemotherapy for Hodgkin disease and soft-tissue and bone sarcoma who meet eligibility requirements will be approached to participate in the study. The purpose of the study is to determine if performing remote ischemic …

  • 0 views
  • 26 Jun, 2021
  • 1 location
None
Carboplatin in EARLY Triple Negative Breast Cancer Trial (PEARLY Trial)

This is a randomized, open-label, multicenter, phase III study comparing anthracyclines followed by taxane to anthracyclines followed by taxane plus carboplatin as (neo)adjuvant therapy in

primary tumor
HER2
anthracyclines
mammogram
sentinel lymph node biopsy
  • 82 views
  • 23 Jan, 2021
  • 12 locations
None
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy

failure) are related to the use of anthracyclines. Anthracyclines are part of the chemotherapy regimen for solid tumors and hematological neoplasms in children and adults, and are associated with an

primary cancer
treatment regimen
anthracyclines
  • 0 views
  • 08 Oct, 2021
  • 1 location
None
Treatment Protocol of the NHL-BFM and the NOPHO Study Groups for Mature Aggressive B-cell Lymphoma and Leukemia in Children and Adolescents

with very limited mature B-NHL (R1 and R2 stage I and II) of substituting anthracyclines by the rituximab window without compromising survival rates. the effectiveness (event-free survival

  • 499 views
  • 16 Jun, 2021
  • 93 locations
None
Study for Patients With Newly Diagnosed High-risk Acute Promyelocytic Leukemia

/ATRA protocol with the addition of two doses of IDA (50% compared to standard AIDA induction) for induction because of the anticipated need of adding anthracyclines to control hyperleukocytosis and to

monoclonal antibody
anthracyclines
consolidation therapy
myeloid leukemia
secondary mds
  • 0 views
  • 26 Aug, 2021
  • 8 locations
None
Carboplatin Intensified Chemotherapy for TRIple NEgative Breast Cancer(CITRINE)

This is a prospective, single center, randomized, open-labled stage III clinical trial comparing the efficacy and safety of anthracyclin followed by weekly paclitaxel versus dose-dense anthracyclin followed by weekly paclitaxel versus dose-dense anthracyclin followed by weekly paclitaxel combined with carboplatin for high-risk, triple-negative early breast cancer.

cancer
platelet count
HER2
erbb2
blood transfusion
  • 20 views
  • 23 Jan, 2021
  • 1 location