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Found 104 clinical trials
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Low Dose Daunorubicin in Pediatric Relapsed/Refractory Acute Leukemia

In this pilot study, eligible pediatric patients will be treated with 5 consecutive days of low dose daunorubicin. All patients who receive low dose daunorubicin will be evaluated daily for potential toxicity during those 5 days. Once the patient has received 5 doses of daunorubicin, subsequent therapy will be at …

  • 0 views
  • 27 Sep, 2021
  • 1 location
None
MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum

This trial studies how well magnetic resonance imaging (MRI) works in detecting heart damage in patients with cancer receiving chemotherapy. Diagnostic procedures, such as MRI, may help doctors predict whether patients will have heart damage caused by chemotherapy in patients with cancer receiving chemotherapy. Exercise Capacity Addendum Brief Summary: This …

breast cancer staging
treatment regimen
cardiac mri
trastuzumab
MRI
  • 0 views
  • 10 Sep, 2021
  • 2 locations
None
Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis

In this study Drug-eluting microbeads (DEB) loaded with Doxorubicin will be delivered into the target Desmoid Fibromatoses (DF) tissue via selective arterial embolization by angiographic technique. The objective of the study is to demonstrate the safety and efficacy of this treatment.

colony stimulating factors
methotrexate
measurable disease
nonsteroidal anti-inflammatory drugs
myelosuppressive chemotherapy
  • 17 views
  • 23 Jan, 2021
  • 1 location
None
Comparing Sequential Neoadjuvant Treatment Including Chemotherapy and Accelerated Radiation Focused to the Tumor Bed vs Neoadjuvant Chemotherapy Alone

In the NeoAPBI 01 trial, the objective is to demonstrate the efficacy of combined APBI and CT administered sequentially in patients with intermediate ad high risk BC. The hypothesis is that combined PST-sequential APBI may increase the rate of pCR, breast conservation and survival without additional toxicity, as seen with …

  • 0 views
  • 16 May, 2021
  • 2 locations
None
CCCG Relapsed Acute Lymphoblastic Leukemia 2017 Study in Children

Relapsed acute lymphoblastic leukaemia (ALL) has a poorer outcome than newly diagnosed ALL patients with only about 40% overall survival after re-treatment. The study CCCG Relapsed ALL 2017 study will adopt the UK R3 study stratification and treatment backbone with two new agents added. There will be a 4-week induction, …

  • 0 views
  • 26 Feb, 2021
  • 1 location
None
A Study to Evaluate the Efficacy and Safety of Obinutuzumab Ibrutinib and Venetoclax in Patients With Richter's Syndrome;

Richter's syndrome (RS) is a life-threatening complication of chronic lymphocytic leukemia (CLL). It is associated with a switch in histopathology and biology, generally with a transformation of the original CLL clone to diffuse large B-cell lymphoma (DLBCL). The development of RS is accompanied by the onset of B symptoms, rapid …

  • 0 views
  • 01 Oct, 2021
  • 4 locations
None
Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer

This phase I/II trial studies the side effect and best dose of neratinib and to see how well it works with paclitaxel and with or without pertuzumab and trastuzumab before combination chemotherapy in treating patients with breast cancer that has spread to other places in the body (metastatic). Neratinib may …

liver metastasis
tumor cells
invasive carcinoma
erbb2
estrogen
  • 12 views
  • 28 Mar, 2021
  • 2 locations
None
Nivolumab in Epstein-Barr Virus (EBV)-Positive Lymphoproliferative Disorders and EBV-Positive Non-HodgkinLymphomas

Background The drug Nivolumab has been approved to treat some cancers. Researchers want to see if it can slow the growth of other cancers. They want to study its effects on cancers that may have not responded to chemotherapy or other treatments. Objectives To see if Nivolumab slows the growth …

ct scan
rituximab
follicle stimulating hormone
anthracycline
bone marrow procedure
  • 173 views
  • 01 Oct, 2021
  • 1 location
None
Safety and Efficacy Study of Idarubicin Dose Intensification to Treat Acute Myeloid Leukemia

The purpose of this study is to determine whether idarubicin dose intensification is safe and effective as a remission induction therapy for acute myeloid leukemia.

neoadjuvant therapy
secondary acute myeloid leukemia
remission
ejection fraction
idarubicin
  • 16 views
  • 23 Jan, 2021
  • 1 location
None
Testing the Addition of Copanlisib to Eribulin for the Treatment of Advanced-Stage Triple Negative Breast Cancer

This phase I/II trial studies the side effects and best dose of copanlisib and how well it works when given together with eribulin in treating patients with triple negative breast cancer that has spread to other places in the body (advanced stage). Copanlisib stops the growth of a protein called …

  • 0 views
  • 26 Sep, 2021
  • 8 locations