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Found 103 clinical trials
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Evaluation of Sequencing of Anthracyclines and Taxanes for Locally Advanced HER2-negative Breast Cancer

Phase III randomized clinical trial evaluating the sequencing of anthracyclines and taxanes in neoadjuvant therapy for locally advanced HER2-negative breast cancer.

HER2
paclitaxel
doxorubicin
cyclophosphamide
carcinoma
  • 0 views
  • 10 Sep, 2021
  • 10 locations
None
Improving the Outcome of High-risk Aggressive B-cell Lymphoma Patients With Nivolumab Maintenance Therapy

This trial is designed as a unicenter, single arm phase II trial. The aim of the trial is to test whether prognosis of high-risk Aggressive B cell Lymphoma (ABCL) patients who are in complete remission (CR) post immunochemotherapy can be improved by 2year nivolumab maintenance therapy. Participants will be recruited …

blood transfusion
remission
diffuse large b-cell lymphoma
anthracyclines
beta human chorionic gonadotropin
  • 2 views
  • 23 Jan, 2021
  • 1 location
None
Physical Capacity in Hodgkin Lymphoma Survivors

The study aims to investigate if physical capacity obtained in the cardiopulmonary exercise test can predict cardiovascular alterations in Hodgkin Lymphoma (HL) Survivors. In addition, to study the effects of exercise training on physical capacity and cardiovascular responses in these patients.

  • 0 views
  • 28 Jan, 2021
  • 1 location
None
DCE-MRI and MBI in Assessing Tumor Response to Chemotherapy in Patients With Triple Negative Breast Cancer

This early phase I trial studies how well dynamic contrast enhanced molecular resonance imaging (DCE-MRI) and technetium-Tc99m sestamibi molecular breast imaging (MBI) work in assessing tumor response to chemotherapy in patients with triple negative breast cancer (TNBC) who are undergoing chemotherapy. Investigational imaging scans such as MBI and DCE-MRI may …

estrogen receptor
HER2
immunohistochemistry
triple negative breast cancer
cancer
  • 0 views
  • 22 Jan, 2021
  • 7 locations
None
Three Fraction Radiation to Induce Immuno-Oncologic Response

Patients with high risk breast cancers (any locally advanced breast cancer patient defined as Stages IIB-III [excluding inflammatory breast cancer] with stage IIA being eligible for triple negative and HER2-positive breast cancers) will receive neoadjuvant radiation to any portion of their tumour in three fractions in order to act as …

  • 0 views
  • 18 Aug, 2021
  • 1 location
None
Comparison of Therapies Before Stem Cell Transplantation in Patients With Higher Risk MDS and Oligoblastic AML

To compare the event-free survival at 2 years of CPX-351 vs. conventional care regimens before allogeneic blood cell transplantation as first line treatment in patients with higher risk MDS and oligoblastic AML.

bone marrow procedure
serum bilirubin level
azacitidine
cell transplantation
ejection fraction
  • 0 views
  • 25 Aug, 2021
  • 26 locations
None
Comparison of Oral Cyclophosphamide vs Doxorubicin in 65 Years Old Advanced or Metastatic Soft Tissue Sarcoma Patients

Most advanced or metastatic soft tissue sarcoma (STS) are unfortunately incurable, making the preservation of the patient's quality of life a major goal, along with prolonging survival. Age is not a criterion for not providing effective treatment, but the goals of treatment change with age and must be integrated into …

  • 0 views
  • 07 Oct, 2021
  • 1 location
None
Study of Immunotherapy in Combination With Chemotherapy in HER2-negative Inflammatory Breast Cancer

This phase II multicentre randomized open-label study will assess the safety and efficacy of Pembrolizumab in combination with standard chemotherapy in inflammatory breast cancer. Pembrolizumab will be administered every 3 weeks during the neoadjuvant chemotherapy. Tissue and blood samples will be collected pre- and post-treatment for translational research.

erythema
HER2
paclitaxel
immunohistochemistry
peau d'orange
  • 7 views
  • 25 Jan, 2021
  • 22 locations
None
Low Dose Daunorubicin in Pediatric Relapsed/Refractory Acute Leukemia

In this pilot study, eligible pediatric patients will be treated with 5 consecutive days of low dose daunorubicin. All patients who receive low dose daunorubicin will be evaluated daily for potential toxicity during those 5 days. Once the patient has received 5 doses of daunorubicin, subsequent therapy will be at …

  • 0 views
  • 06 Nov, 2021
  • 1 location
None
MRI in Detecting Heart Damage in Patients With Cancer Receiving Chemotherapy With Exercise Capacity Addendum

This trial studies how well magnetic resonance imaging (MRI) works in detecting heart damage in patients with cancer receiving chemotherapy. Diagnostic procedures, such as MRI, may help doctors predict whether patients will have heart damage caused by chemotherapy in patients with cancer receiving chemotherapy. Exercise Capacity Addendum Brief Summary: This …

breast cancer staging
paclitaxel
stage iv breast cancer
treatment regimen
MRI
  • 0 views
  • 10 Sep, 2021
  • 2 locations